Ventricular pacing to augment atrial natriuretic hormone production
First Claim
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1. An apparatus comprising:
- a cardiac rhythm management device comprising;
a ventricular pacing circuit, configured to deliver a ventricular pace; and
a processor circuit, coupled to the ventricular pacing circuit, the processor configured to comprise a first operating mode, the processor configured to time delivery of the ventricular pace, when in the first operating mode, so that;
delivery of the ventricular pace is synchronized to occur during an atrial diastole time period;
delivery of the ventricular pace results in a substantial overlap of ventricular systole and atrial systole; and
a paced ventricular contraction is substantially concurrent with a paced or sensed atrial contraction during the same cardiac cycle.
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Abstract
Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.
51 Citations
20 Claims
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1. An apparatus comprising:
a cardiac rhythm management device comprising; a ventricular pacing circuit, configured to deliver a ventricular pace; and a processor circuit, coupled to the ventricular pacing circuit, the processor configured to comprise a first operating mode, the processor configured to time delivery of the ventricular pace, when in the first operating mode, so that; delivery of the ventricular pace is synchronized to occur during an atrial diastole time period; delivery of the ventricular pace results in a substantial overlap of ventricular systole and atrial systole; and a paced ventricular contraction is substantially concurrent with a paced or sensed atrial contraction during the same cardiac cycle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An apparatus comprising:
a cardiac rhythm management device comprising; a ventricular pacing circuit, configured to deliver a ventricular pace; a processor circuit, coupled to the ventricular pacing circuit, the processor configured to comprise a first operating mode, the processor configured to time delivery of the ventricular pace, when in the first operating mode, so that;
delivery of the ventricular pace is synchronized to occur during an atrial diastole time period, and delivery of the ventricular pace results in a substantial overlap of ventricular systole and atrial systole; anda physiologic sensor, coupled to the processor, the physiologic sensor configured to measure physiologic parameters of a subject including a physical activity, a cardiac output, and a fluid status; wherein the processor is configured to adjust the first operating mode based on the physiologic parameters, including using information about the fluid status and limiting use of the first mode of operation to when the physical activity is above a first threshold and to when cardiac output is below a second threshold. - View Dependent Claims (17, 18)
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19. A cardiac rhythm management device comprising:
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a ventricular pacing circuit; and a processor circuit coupled to the ventricular pacing circuit, the processor configured to control the ventricular pacing circuit to time delivery of a ventricular pace so that; delivery of the ventricular pace is synchronized with an atrial diastole time period; delivery of the ventricular pace results in overlap of ventricular systole and atrial systole; and a paced ventricular contraction is synchronized with a paced or sensed atrial contraction during the same cardiac cycle. - View Dependent Claims (20)
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Specification