Active agents and their oligomers and polymers

• US 9,108,070 B2
• Filed: 05/09/2012
• Issued: 08/18/2015
• Est. Priority Date: 09/13/2006
• Status: Active Grant

• Current Assignee: Polymerix Corporation
• Original Assignee: Polymerix Corporation
• Inventors: Kanamathareddy, Suseela, Giroux, Karen J.
• Primary Examiner(s): Katakam, Sudhakar
• Assistant Examiner(s): Sawyer, Jennifer C
• Application Number:
  US13/467,623
• Publication Number:
  US 20130071458A1
• Time in Patent Office: 1,196 Days
• US Class Current: 1/1
• CPC Class Codes: A01N 39/02 Aryloxy-carboxylic acids; Derivatives thereof
• CPC Class Codes: A61K 31/616 by carboxylic acids, e.g. acetylsalicylic acid
• CPC Class Codes: A61K 47/542 Carboxylic acids, e.g. a fatty acid or an amino acid
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/69 containing fluorine
• CPC Class Codes: A61K 8/8164 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.

Claims

1. A compound according to formula (I):

2. The compound of claim 1 having the formula:

3. A composition comprising an effective amount of the compound of claim 1 and a vehicle.

4. A method for treating conditions of the hair, skin or scalp of a mammal comprising administering the composition of claim 3 to a mammal.

7. A device coated with or comprised of the compound of claim 1.

8. A method for inhibiting mold, bacteria or biofilm formation on a surface comprising applying an effective amount of the compound of claim 1 to the surface or admixing an effective amount of the compound of claim 1 with the surface as it is formed.

9. The composition of claim 3, wherein the vehicle is a dermatologically or pharmaceutically acceptable carrier.

5. A topical composition comprising a surfactant and a therapeutically effective amount of a compound having the formula:

6. A method for treating conditions of the hair, skin or scalp of a mammal comprising administering the composition of claim 5 to a mammal.