Synthetic insecticidal proteins active against corn rootworm
First Claim
1. A modified Cry3 pesticidal polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 1, 2, 3, 8, 11, or 14.
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Accused Products
Abstract
Traditionally, the primary method for impacting insect pest populations is the application of broad-spectrum chemical insecticides. However, there is increasing concern about the environmental hazards associated with the production and use of synthetic chemical pesticides. Thus, there is substantial interest in developing alternative pesticides, including biological control of insect pests of agricultural significance using a microbial agent or another species of insect. The present invention provides compositions and methods for such biological control. Modified Cry3 pesticidal polypeptides, polynucleotides encoding such polypeptides, and methods of use are disclosed. The modified polynucleotides provided herein can be used to transform organisms and cells of hosts comprising plant, insects, and microorganisms. The expression of modified polypeptides can provide the host with improved insecticidal activity against one or more insect pathogens.
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Citations
26 Claims
- 1. A modified Cry3 pesticidal polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
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13. A method for producing a plant having improved pesticidal activity, said method comprising introducing into said plant a polynucleotide having a nucleotide sequence that encodes a modified Cry3 pesticidal polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 1, 2, 3, 8, 11, or 14.
Specification