HER-3 antibodies and methods of use
First Claim
Patent Images
1. A monoclonal Her-3 antibody comprising (a) a light chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs:
- 13, 14 and 15, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
16, 17 and 18, respectively, or a monoclonal Her-3 antibody comprising (a) a light chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
19, 20 and 21, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
22, 23 and 24, respectively.
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Abstract
The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.
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Citations
34 Claims
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1. A monoclonal Her-3 antibody comprising (a) a light chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs:
- 13, 14 and 15, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
16, 17 and 18, respectively, or a monoclonal Her-3 antibody comprising (a) a light chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
19, 20 and 21, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
22, 23 and 24, respectively. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 27, 29, 31, 33)
- 13, 14 and 15, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs;
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2. A monoclonal Her-3 antibody comprising the amino acid sequences set forth in SEQ ID NOs:
- 9 and 11 for the light and heavy chains, respectively, or a monoclonal Her-3 antibody comprising the amino acid sequences set forth in SEQ ID NOs;
10 and 12 for the light and heavy chains, respectively. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28, 30, 32, 34)
- 9 and 11 for the light and heavy chains, respectively, or a monoclonal Her-3 antibody comprising the amino acid sequences set forth in SEQ ID NOs;
Specification