Apparatus and method for multi-modal imaging

• US 9,113,784 B2
• Filed: 09/21/2011
• Issued: 08/25/2015
• Est. Priority Date: 09/08/2005
• Status: Active Grant

• Current Assignee: Bruker Biospin Corporation (Bruker Corporation)
• Original Assignee: Bruker Biospin Corporation (Bruker Corporation)
• Inventors: Feke, Gilbert D., McLaughlin, William E., Vizard, Douglas L.
• Primary Examiner(s): Gupta, Vani
• Application Number:
  US13/238,290
• Publication Number:
  US 20120008742A1
• Time in Patent Office: 1,434 Days
• Field of Search: 600/407, 250/339.06, 250/336.1, 250/367, 378/51
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/17 Comprising radiolucent components
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 6/00 Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment instruments measuring radiation intensity for application in the field of nuclear medicine, e.g. in vivo counting, G01T1/161; apparatus for taking X-ray photographs G03B42/02
• CPC Class Codes: A61B 6/4417 related to combined acquisition of different diagnostic modalities
• CPC Class Codes: A61B 6/5247 combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound

Abstract

An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member.

Claims

1. An imaging system for imaging an object, comprising:

a support member adapted to receive the object in an immobilized state;

an imaging unit that images the immobilized object in a first imaging mode to capture a first image, the first imaging mode being selected from the group consisting of;

x-ray mode and radio isotope mode, and that images the immobilized object in a second imaging mode that uses light from the immobilized object, different from the first imaging mode, to capture a second image, the second imaging mode being selected from the group consisting of;

bright-field mode, fluorescence mode, and luminescence mode;

a movable phosphor plate to transduce ionizing radiation to visible light, the phosphor plate being mounted to be moved, while the object remains immobilized on the support member, between;

a first position proximate the support member for and during capture of the first image; and

a second position not proximate the support member during capture of the second image; and

a capture system that captures either the first image or the second image of the object.

2. The imaging system of claim 1, further comprising an image merging unit that generates a third image by merging the first and second images.

3. The imaging system of claim 1, further comprising multiple optical elements to enable the location of a common focal plane shared by the first and second imaging modes.

4. An imaging system for imaging an object, comprising:

a support member adapted to receive the object in an immobilized state;

an imaging unit that images

the immobilized object in a first imaging mode to capture a first image, the first imaging mode being selected from the group consisting of;

x-ray imaging mode and isotope imaging mode, and images

the immobilized object in a second imaging mode that uses light from the object to capture a second image, the second imaging mode being selected from the group consisting of;

bright-field imaging mode and dark-field imaging mode;

a movable phosphor plate mounted to be selectively movable between a first position proximate the support member when capturing the first image and a second position not proximate the support member prior to capturing the second image; and

a capture system that captures either the first image or the second image of the object.

5. The imaging system of claim 4, further comprising an image merging unit that generates a third image by merging the first and second images.

6. The imaging system of claim 4, further comprising multiple optical elements to enable the location of a common focal plane shared by the first and second imaging modes.