Methods and systems for continuous EEG monitoring

• US 9,113,801 B2
• Filed: 12/29/2006
• Issued: 08/25/2015
• Est. Priority Date: 08/05/1998
• Status: Expired due to Term

• Current Assignee: DiLorenzo Biomedical, LLC
• Original Assignee: Cyberonics, Inc
• Inventors: DiLorenzo, Daniel John
• Primary Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US11/647,785
• Publication Number:
  US 20070161919A1
• Time in Patent Office: 3,161 Days
• Field of Search: 600544-545
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/1101 Detecting tremor
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6864 Burr holes
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61B 5/6882 Anchoring means
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36114 : Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36139 : with automatic adjustment
• CPC Class Codes: A61N 1/372 : Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/3787 : from an external energy source

Abstract

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Claims

1. A method of monitoring and storing EEG signals from a patient, the method comprising:

establishing a wireless communication link between an implanted unit and a communication module that is external to the patient'"'"'s body, wherein the implanted unit is coupled to an intracranial catheter having a distal end positioned inside the patient'"'"'s calvarium, the intracranial catheter containing one or more wires coupling the implanted unit to one or more intracranial recording electrodes and one or more wires coupling the implanted unit to one or more intracranial stimulating electrodes;

monitoring EEG signals from the patient with the intracranial recording electrodes and the implanted unit substantially continuously while the wireless communication link is established;

wirelessly transmitting in substantially real-time the monitored EEG signals from the implanted unit to the communication module that is external to the patient'"'"'s body substantially continuously while the wireless communication link is established;

storing the EEG signals in a memory in the communication module;

monitoring high frequency head vibration, muscle vibration, or speech production using an acoustic sensor mounted in the patient'"'"'s head and coupled to the implanted unit; and

monitoring head movement and position with respect to gravity using an accelerometer mounted in the patient'"'"'s head and coupled to the implanted unit.

2. The method of claim 1 wherein the communication module is a portable patient interface module, and wherein the memory is within the portable patient interface module.

3. The method of claim 1 wherein the communication module is a supervisory module that is used by a healthcare provider, and wherein the memory is within the supervisory module.

4. The method of claim 1 wherein storing the transmitted EEG signals creates a time history record of the EEG signals for a time period when the wireless communication link is established between the implanted unit and the communication module.

5. The method of claim 1 further comprising wirelessly transmitting a stored time history of the EEG signals that was previously stored in a memory of the implanted unit.

6. The method of claim 1 further comprising

analyzing the EEG signals to estimate the patient'"'"'s condition.

7. The method of claim 6 wherein analyzing the EEG signals from the patient to estimate the patient'"'"'s condition comprises predicting future symptomatology of the patient'"'"'s condition.

8. The method of claim 1 further comprising

using the communication module to provide an output to the patient that is indicative of the patient'"'"'s estimated condition.

9. The method of claim 7 further comprising

initiating delivery of a therapy to the patient when the future symptomatology is predicted.

10. The method of claim 1, further comprising:

monitoring electromyographic signals using an electromyography electrode array positioned in the patient'"'"'s neck.

11. The method of claim 1, further comprising:

storing stimulation electrode impedance history in the implanted unit.

12. The method of claim 1, further comprising:

monitoring eyelid movement using EMG sensors to determine frequency of eye blinking.