Non-electric field renal denervation electrode

• US 9,113,929 B2
• Filed: 02/28/2013
• Issued: 08/25/2015
• Est. Priority Date: 04/19/2012
• Status: Active Grant

• Current Assignee: St. Jude Medical Cardiology Division Incorporated (Abbott Laboratories)
• Original Assignee: St. Jude Medical Cardiology Division Incorporated (Abbott Laboratories)
• Inventors: Parsonage, Edward E.
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US13/781,136
• Publication Number:
  US 20130282000A1
• Time in Patent Office: 908 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2018/00059 Material properties
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00095 high, i.e. heat conducting
• CPC Class Codes: A61B 2018/00136 with polymer
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00267 having a basket shaped structure
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00577 Ablation

Abstract

A renal denervation device can include an elongated catheter body extending along a longitudinal axis, and an assembly connected to the catheter body. The assembly includes a plurality of heating elements connected to the catheter body. Each heating element has a conductor and a layer of an RF dissipating material such as a polymer overlying the conductor. During operation of the device, the layer of RF dissipating material is disposed between the conductor and body tissues of a subject. The layer of RF dissipating material is substantially thicker than the Debye length within the material in order to reduce the electric field reaching the tissue and to eliminate direct contact of the electrode with the body tissue.

Claims

1. An RF treatment device comprising:

a device body; and

an assembly connected to the device body comprising one or more heating elements connected to the device body, each heating element having a conductor and a layer of an RF dissipating material overlying the conductor so that the layer of RF dissipating material is disposed between the conductor and body tissues of a subject when the assembly is in an operative position within the body of the subject, wherein the RF dissipating layer has a thickness and a Debye length, the thickness of the dissipating layer being greater than the Debye length.

2. The device of claim 1, wherein the RF dissipating material includes a polymeric material.

4. The device of claim 2, wherein the polymeric material is selected from the group consisting of sulfonated perfluoropolyethers, hydrogenated and fluorinated polyakylene oxides, polyphosphazenes, polyethyleneimines, polyvinyl alcohols, polyvinyl pyrolidones, hydrolyzed polyacrylonitrile, crosslinked polypeptides, carboxylate-containing polymers, sulfonic acid-containing polymers, and phosphate-containing polymers.

5. The device of claim 4 wherein the polymeric material further comprises a salt, the salt further comprising a cationic component and an anionic component.

6. The device of claim 5 wherein the cationic component is selected from the group consisting of lithium, sodium, potassium and ammonium.

7. The device of claim 5 wherein the anionic component is selected from the group consisting of carboxylates, carbonates, phosphates, perchlorates and triflates.

8. The device of claim 1, wherein the RF dissipating material includes a ceramic material.

9. The device of claim 8, wherein the ceramic material is selected from the group consisting of tricalcium phosphate, hydroxyapatite, carbonates, sulfates, zirconium oxides, zirconium phosphates, lanthanum fluoride, silver sulfide, and Nasicon.

10. The device of claim 1, wherein the RF dissipating layer has a thickness between 10 μ

m and 100 μ

m.

11. The device of claim 1, wherein the Debye length is approximately 1 μ

m.

12. The device of claim 1, wherein a ratio of the thickness of the layer of polymeric material to the Debye length of the RF dissipating material is at least 3:

1.

13. The device of claim 1, further comprising an RF power source operatively connected to the at least one heating element.

14. The device of claim 13, wherein the power source is capable of providing 6 watts of radiofrequency power at a frequency of 485 KHz.

15. The device of claim 1, wherein the device body includes a catheter extending along a longitudinal axis.

16. The device of claim 15, wherein the heating elements are distributed around the longitudinal axis.

3. The device is selected wherein the polymeric from the group consisting of solid polymeric hydrogel electrolytes, polyelectrolytes, ionomers and combinations thereof.

17. A method of providing RF treatment comprising the steps of:

positioning one or more heating elements within a blood vessel of a mammalian subject, each heating element having a conductor and a layer of an RF dissipating material overlying the metallic conductor, the positioning step being performed so that the layer of RF dissipating material is disposed between the conductor and a wall of the blood vessel; and

applying RF power to the conductors of the heating elements to heat tissues of the subject, the RF dissipating material of the heating elements substantially blocking transmission of RF electric fields to the tissues of the subject.

18. A method as claimed in claim 17 wherein the heating elements are mounted to an elongated catheter body and the positioning step includes inserting the catheter body into the blood vessel.

19. A method as claimed in claim 18 wherein the blood vessel is a renal artery and the heating step is performed so that heat transferred from the heating elements at least partially causes neuromodulation of one or more renal nerves of the subject.

20. The method of claim 19, wherein the power source supplies about 6 watts of power.

21. The method of claim 20, wherein the power source operates at a frequency of about 485 KHz.

22. The method of claim 21, wherein the at least one heating element is heated for about 90 seconds.