Apparatus and method for treating cardiovascular diseases

• US 9,114,035 B2
• Filed: 04/26/2007
• Issued: 08/25/2015
• Est. Priority Date: 04/26/2006
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Oberti, Carlos, Navia, Jose Luis
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Mathew, Seema
• Application Number:
  US11/789,827
• Publication Number:
  US 20070255389A1
• Time in Patent Office: 3,043 Days
• Field of Search: 623/1.44
• US Class Current: 1/1
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2250/003 differing in adsorbability or resorbability, i.e. in adsorption or resorption time
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy

Abstract

An apparatus for treating cardiovascular diseases includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions for positioning in a blood vessel. The proximal end portion of the expandable support member includes a plurality of wing members that extend from the main body portion. Each of the wing members is for engaging at least a portion of an antrum of a cardiac chamber surrounding the blood vessel. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into the blood vessel, the cardiac chamber, and/or cardiac tissue. The expandable support member is made of wire-mesh, and at least a portion of the expandable support member may be made of a bioabsorbable material.

Claims

1. An apparatus for placement in a blood vessel to treat cardiac arrhythmias, said apparatus comprising:

an expandable support member having a first mesh-like configuration, wherein at least a portion of the expandable support member is treated with a therapeutic agent;

a plurality of wing members that extend from only a proximal end of said expandable support member, each of said plurality of wing members independently having a second mesh-like configuration, each of said plurality of wing members being radially spaced apart from one another, and each of said plurality of wing members having a free end shaped to conform to a portion of an antrum of a cardiac chamber surrounding the blood vessel to engage with the portion of the antrum of the cardiac chamber surrounding the blood vessel; and

an electrical mechanism coupled to said expandable support member for delivering electrical energy to at least a portion of an ostium of the blood vessel to ablate tissue.

2. The apparatus of claim 1 wherein said expandable support member, in its expanded form, is shaped to conform to the shape of at least a portion of the blood vessel.

3. The apparatus of claim 1 wherein each of said wing members extends beyond the proximal end of the expandable support member:

wherein the proximal end of the expandable support member extends with a portion of each of the wing members.

4. The apparatus of claim 1 wherein a plurality of portions of said expandable support member are separately treated with a different one of a plurality of therapeutic agents.

5. The apparatus of claim 1, wherein each of said plurality of wing members is separately treated with a therapeutic agent.

6. The apparatus of claim 5, wherein each of said plurality of wing members is separately treated with a different one of a plurality of therapeutic agents.

7. The apparatus of claim 1 wherein a portion of said expandable support member is bioabsorbable.

8. The apparatus of claim 1 further comprising an inflatable balloon configured to expand said expandable support member to engage the at least the portion of the ostium of the blood vessel.

9. The apparatus of claim 1 further comprising a capsule containing said expandable support member in a collapsed configuration,

wherein said capsule is removable to allow said expandable support member to expand into the at least the portion of the ostium of the blood vessel.

10. The apparatus of claim 1, wherein at least a portion of said expandable support member is covered with a layer of biocompatible material selected from the group consisting of GORE-TEX and expanded PTFE.

11. The apparatus of claim 1, wherein each of said plurality of wing members has an arch-like shape.

12. The apparatus of claim 1, wherein said expandable support member is configured to elute the therapeutic agent into the blood vessel or the cardiac chamber.

13. The apparatus of claim 1, wherein the first mesh-like configuration is different from the second mesh-like configuration.

14. An apparatus for placement in a blood vessel to treat a cardiac arrhythmia, said apparatus comprising:

an expandable support member comprising a first wire-mesh configuration, wherein at least a portion of said expandable support member is treated with a therapeutic agent;

a plurality of arch-shaped wing members extending from a proximal end of said expandable support member and being radially spaced apart from one another, each of said plurality of wing members independently comprising a second wire-mesh configuration, and each of said plurality of wing members having a free end adapted for engaging a portion of an antrum of a cardiac chamber surrounding the blood vessel; and

an electrical mechanism coupled to said expandable support member for delivering electrical energy to at least a portion of an ostium of the blood vessel to ablate tissue.

15. The apparatus of claim 14, wherein at least one of the plurality of wing members is treated with a second therapeutic agent.

16. The apparatus of claim 15, wherein the therapeutic agent comprises an anti-inflammatory therapeutic agent and the second therapeutic agent comprises an anti-coagulant therapeutic agent.

17. The apparatus of claim 14, wherein each of said wing members extends beyond the proximal end of the expandable support member.

18. The apparatus of claim 17, wherein the proximal end of the expandable support member extends with a portion of each of the wing members.

19. The apparatus of claim 18, wherein the proximal end of the expandable support member extends with 50% or less of each of the wing members.

20. An apparatus configured to be placed in a blood vessel, said apparatus comprising:

an expandable support member comprising a first wire-mesh configuration, wherein at least a portion of said expandable support member is treated with a therapeutic agent;

a plurality of wing members extending from a proximal end of said expandable support member, each of said plurality of wing members independently comprising a second wire-mesh configuration different from the first wire-mesh configuration, and each of said plurality of wing members having a free end adapted for engaging a portion of an antrum of a cardiac chamber surrounding the blood vessel,

wherein each of the plurality of wing members comprises an arch-shaped perimeter that bounds the second wire-mesh configuration; and

an electrical mechanism coupled to said expandable support member for delivering electrical energy to at least a portion of an ostium of the blood vessel to ablate tissue.

21. The apparatus of claim 20, wherein the proximal end of the expandable support member extends up to less than the entire perimeter of each of the plurality of wing members.