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Immobilized biologically active entities having high biological activity following mechanical manipulation

  • US 9,114,194 B2
  • Filed: 05/12/2006
  • Issued: 08/25/2015
  • Est. Priority Date: 05/12/2006
  • Status: Active Grant
First Claim
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1. A compacted and expanded medical device comprising:

  • a fluoropolymeric substrate material;

    a polymeric covering material attached to at least a portion of a surface of said substrate material, a plurality of biologically active entities having anti-thrombin III binding activity covalently attached to at least a portion of said polymeric covering material; and

    a biologically compatible polysaccharide non-covalently combined with said polymeric covering material and said biologically active entities,wherein said biologically active entities have an anti-thrombin III binding activity of at least 5 picomoles anti-thrombin III per square centimeter (pmol/cm2) substrate material when measured following compaction of said medical device to 50% of said medical device'"'"'s original size and expansion of said medical device.

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