Chemical liquid addition system and chemical liquid addition method

• US 9,114,205 B2
• Filed: 03/16/2011
• Issued: 08/25/2015
• Est. Priority Date: 03/16/2010
• Status: Active Grant

• Current Assignee: Asahi Kasei Medical Co., Ltd. (Asahi Kasei Corporation)
• Original Assignee: Asahi Kasei Medical Co., Ltd. (Asahi Kasei Corporation)
• Inventors: Yokomizo, Tomohisa, Inadome, Shuichiro
• Primary Examiner(s): Cleveland, Timothy
• Application Number:
  US13/635,074
• Publication Number:
  US 20130005557A1
• Time in Patent Office: 1,623 Days
• Field of Search: 494/45, 604/6.07, 604408-410, 604/416, 210/781, 210/782, 210/787
• US Class Current: 1/1
• CPC Class Codes: A61M 1/0218 with filters
• CPC Class Codes: A61M 1/0272 Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
• CPC Class Codes: B04B 5/0428 with flexible receptacles

Abstract

The preservation liquid addition system of the present invention enables a chemical liquid to be added to a blood cell component both easily and in a short period of time. The preservation liquid addition system is able to be placed on a centrifugal separator. The preservation liquid addition system has a blood bag, a preservation liquid bag, a mixed liquid bag, a first flow path and a static mixer. A blood component in the blood bag and a preservation liquid in the preservation liquid bag are sent to the static mixer through the first flow path, and a mixed liquid mixed by the static mixer is sent to the mixed liquid bag by centrifugal force of the centrifugal separator.

Claims

1. A chemical liquid addition system that is placed on a centrifugal separator and that adds a chemical liquid to a body fluid component of a body fluid, comprising:

the body fluid bag that holds a body fluid;

a chemical liquid bag that holds a chemical liquid;

a mixed liquid bag that holds a mixed liquid of the body fluid component of the body fluid and the chemical liquid;

a flow path that connects the body fluid bag, the chemical liquid bag and the mixed liquid bag; and

a mixing device that mixes the body fluid component sent from the body fluid bag with the chemical liquid sent from the chemical liquid bag in the flow path while the body fluid component and the chemical liquid flow therethrough, wherein,

the body fluid component of body fluid in the body fluid bag and the chemical liquid in the chemical liquid bag are sent to the mixing device through the flow path, and the mixed liquid mixed by the mixing device is sent to the mixed liquid bag, by centrifugal force of the centrifugal separator.

2. The chemical liquid addition system according to claim 1, wherein the flow path is connected to ends of the body fluid bag and the chemical liquid bag in a direction of centrifugal force of the centrifugal separator when the system is placed on the centrifugal separator.

3. The chemical liquid addition system according to claim 1, comprising:

a body fluid component bag holding a body fluid component other than the body fluid component that flows to the flow path; and

another flow path that connects the body fluid bag and the body fluid component bag.

4. The chemical liquid addition system according to claim 3, wherein the another flow path is connected to the end of the body fluid bag on the side in a direction of centrifugal force of the centrifugal separator when the system is placed on the centrifugal separator.

5. The chemical liquid addition system according to claim 1, wherein

the body fluid is blood,

the body fluid component flowing to the flow path is a red cell component composed mainly of red blood cells, and

the chemical liquid is a preservation liquid for preserving the red cell component.

6. The chemical liquid addition system according to claim 1, wherein a filter that removes a predetermined undesired substance from the mixed liquid is provided in the flow path.

10. The chemical liquid addition system according to claim 2, comprising:

a body fluid component bag holding a body fluid component other than the body fluid component that flows to the flow path; and

another flow path that connects the body fluid bag and the body fluid component bag.

11. The chemical liquid addition system according to claim 10, wherein the another flow path is connected to the end of the body fluid bag on the side in the direction of centrifugal force of the centrifugal separator when the system is placed on the centrifugal separator.

12. The chemical liquid addition system according to claim 2, wherein

the body fluid is blood,

the body fluid component flowing to the flow path is a red cell component composed mainly of red blood cells, and

the chemical liquid is a preservation liquid for preserving the red cell component.

13. The chemical liquid addition system according to claim 2, wherein a filter that removes a predetermined undesired substance from the mixed liquid is provided in the flow path.

7. A chemical liquid addition method for adding a chemical liquid to a body fluid component of a body fluid in use of:

a body fluid bag holding the body fluid;

a chemical liquid bag holding a chemical liquid;

a mixed liquid bag;

a flow path that connects the body fluid bag, the chemical liquid bag and the mixed liquid bag;

a mixing device that mixes in the flow path the body fluid component sent from the body fluid bag with the chemical liquid sent from the chemical liquid bag while the body fluid component and the chemical liquid flow therethrough; and

a centrifugal separator that centrifugally separates the body fluid in the body fluid bag, the method comprising;

a step of separating the body fluid in the body fluid bag into a plurality of body fluid components by the centrifugal separator,

a step of sending at least one of the separated body fluid components in the body fluid bag and the chemical liquid in the chemical liquid bag to the mixing device through the flow path by centrifugal force of the centrifugal separator,

a step of mixing the at least one of the separated body fluid components with the chemical liquid by the mixing device, and

a step of sending the mixed liquid that has been mixed to the mixed liquid bag through the flow path.

8. The chemical liquid addition method according to claim 7, comprising:

a step of removing a predetermined undesired substance from the mixed liquid through a filter.

9. The chemical liquid addition method according to claim 8, wherein

a plurality of separation layers having different concentrations of the predetermined undesired substance are formed from the body fluid in the body fluid bag by the centrifugal separator, and

the plurality of separation layers are sent to the filter in order starting with the layer having the highest concentration of the predetermined undesired substance.