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Polymer coated ceria nanoparticles for selective cytoprotection

  • US 9,119,391 B1
  • Filed: 07/08/2008
  • Issued: 09/01/2015
  • Est. Priority Date: 07/16/2007
  • Status: Active Grant
First Claim
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1. A process for protecting normal, non-transformed biological cells using a pH-dependent therapeutic agent, comprising:

  • providing a plurality of biocompatible, polymer-coated cerium oxide nanoparticles having a pH-dependent antioxidant property, said polymer-coated cerium oxide nanoparticles being an active antioxidant in pH range from 7 to approximately 11 while having a substantially reduced antioxidant activity at an acidic pH from approximately 2 to 6, said polymer-coated cerium oxide nanoparticles not able to reversibly switch from Ce3+ to Ce4+ at said acidic pH; and

    adding an effective amount of said polymer-coated cerium oxide nanoparticles to a cell environment containing normal biological cells and diseased biological cells so as to contact said normal biological cells and diseased biological cells, thereby selectively protecting said normal, non-transformed cells from hydroxyl-radical induced oxidative, nitroxyl-radical induced oxidative stress, radiation therapy, inflammation or chemotherapy, while providing no cytoprotection to said diseased cells.

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