Pressure gauge, blood pressure gauge, method of determining pressure values, method of calibrating a pressure gauge, and computer program

• US 9,119,536 B2
• Filed: 12/30/2008
• Issued: 09/01/2015
• Est. Priority Date: 01/11/2008
• Status: Active Grant

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Original Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Inventors: Douniama, Christian, Tobola, Andreas, Benz, Michaela, Norgall, Thomas, Couronne, Robert, Weigand, Christian, Wentzlaff, Holger
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US12/812,280
• Publication Number:
  US 20120065525A1
• Time in Patent Office: 2,436 Days
• Field of Search: 600/485
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295

Abstract

A pressure gauge for determining at least one pressure value describing a pressure of a fluid flowing in a pulsating manner in a phase of the pulsating flow, includes a pulse wave characterizer. The pulse wave characterizer is configured to obtain transmit time information of a pulse wave, and amplitude information of the pulse wave. The pressure gauge additionally includes a pressure value determiner configured to obtain a first pressure value describing a pressure of the fluid in a first phase, on the basis of the transmit time information and while using a mapping. The pressure value determiner is further configured to obtain a second pressure value describing a pressure of the fluid in a second phase, on the basis of the first pressure value and the amplitude information while using a mapping.

Claims

1. A pressure gauge for determining at least one pressure value describing a pressure of a fluid flowing in a pulsating manner in a phase of the pulsating flow, comprising:

a pulse wave characterizer configured to acquire transit time information describing a transit time of a pulse wave between a first location and a second location, and amplitude information describing a change in a measurement signal, which is based on the pulse wave, between two phases of the pulse wave; and

a pressure value determiner configured to acquire a first pressure value describing a pressure of the fluid in a first phase of the pulsating flow on the basis of the transit time information and while using a first mapping which maps the transit time of the pulse wave to the first pressure value, wherein

the pressure value determiner is configured to acquire a second pressure value describing a pressure of the fluid in a second phase of the pulsating flow on the basis of the first pressure value and the amplitude information while using a second mapping,

the second mapping describes a relationship, which depends on the first pressure value, between the first pressure value, the second pressure value and the amplitude information,

the second mapping further describes a relationship between an amplitude of the measurement signal and an amplitude of the pulse wave, taking into account the first pressure value,

the second mapping describes a difference between the first pressure value and the second pressure value that is dependent on the amplitude information and on the first pressure value,

the second pressure value represents a systolic pressure value, and

the pressure gauge is implemented by a hardware apparatus, a computer, or a combination of a hardware apparatus and a computer.

2. The pressure gauge as claimed in claim 1, wherein the pressure gauge is a blood pressure gauge that determines the systolic blood pressure value;

wherein the pulse wave characterizer is configured to acquire the amplitude information such that the amplitude information describes the amplitude of a measurement signal based on the pulse wave;

wherein the pressure value determiner is a blood pressure value determiner that is configured to acquire, as the first pressure value, a first blood pressure value on the basis of the transit time information and while using the first mapping, which maps the transit time of the pulse wave to the first blood pressure value, and

wherein the pressure value determiner is configured to acquire, as the second pressure value, a second blood pressure value on the basis of the first blood pressure value and the amplitude information while using the second mapping; and

wherein the second mapping describes a relationship, which depends on the first blood pressure value, between the amplitude information and a pressure amplitude of the pulse wave described by the measurement signal.

3. The pressure gauge as claimed in claim 1, wherein the pulse wave characterizer is configured to receive a first plethysmograph signal and a second plethysmograph signal and to generate the transit time information on the basis of the first plethysmograph signal and the second plethysmograph signal.

4. The pressure gauge as claimed in claim 1, wherein the pulse wave characterizer is configured to create the amplitude information on the basis of a plethysmograph signal, such that the amplitude information at least approximately describes an amplitude of the plethysmograph signal.

5. The pressure gauge as claimed in claim 1, the pressure gauge comprising at least one plethysmograph configured to provide a plethysmograph signal which describes a temporal course of a blood circulation of a blood vessel or a temporal course of a change in volume of a fluid conductor.

6. The pressure gauge as claimed in claim 1, the pressure gauge comprising at least two plethysmographs, a first plethysmograph being configured to provide a first plethysmograph signal which describes a temporal course of a blood circulation of a blood vessel at a first location, and

wherein a second plethysmograph is configured to provide a second plethysmograph signal which describes a temporal course of a blood circulation of a blood vessel at a second location.

7. The pressure gauge as claimed in claim 6, wherein the first plethysmograph and the second plethysmograph are configured to be mounted on a shared vascular section which is homogenous with regard to vascular anatomy, and

to provide measurement signals which describe a propagation of a pulse wave within the vascular section.

8. The pressure gauge as claimed in claim 6, wherein the first plethysmograph and the second plethysmograph are configured to be jointly arranged, at a predefined distance, on an upper arm, a forearm, a thigh or a lower leg.

9. The pressure gauge as claimed in claim 1, wherein the pressure value determiner is configured to evaluate, when the first pressure value is determined, a first mapping specification which at least approximately describes a relationship between a blood pressure and a compliance of a blood vessel.

10. The pressure gauge as claimed in claim 9, wherein the blood pressure determiner is configured to evaluate, as the first mapping specification which at least approximately describes a relationship between a blood pressure and a compliance of a blood vessel, a Gaussian-curve type mapping specification.

11. The pressure gauge as claimed in claim 9, wherein the pressure value determiner is configured to square, when the first pressure value is determined, a transit time value described by the transit time information, so as to acquire the first blood pressure value on the basis of the squared transit time value while using the first mapping specification describing the relationship between a blood pressure value and a compliance of a blood vessel.

12. The pressure gauge as claimed in claim 1, wherein the pressure value determiner is configured to evaluate, when the second pressure value is determined, a second mapping specification describing a relationship between a pressure value or a pressure difference and a volume value or a change in the volume of an elastic fluid conductor or a blood vessel.

13. The pressure gauge as claimed in claim 12, wherein the pressure value determiner is configured to evaluate, as the second mapping specification describing a relationship between a pressure value or a pressure difference and a volume value or a change in the volume of an elastic fluid conductor or a blood vessel, a sigmoidal mapping specification.

14. The pressure gauge as claimed in claim 12, wherein the pressure value determiner is configured to use the amplitude information as a measure of a change in the volume of an elastic fluid conductor or of a blood vessel, and

to determine the second pressure value or blood pressure value while starting from the first pressure value or blood pressure value and while taking into account the change in volume described by the amplitude information and while using a mapping specification describing a non-linear relationship between pressure or blood pressure and a volume of an elastic fluid conductor or blood vessel.

15. The pressure gauge as claimed in claim 1, the pressure gauge being configured to acquire a mapping specification, which describes the second mapping, by integrating a mapping specification which describes the first mapping.

16. The pressure gauge as claimed in claim 1, wherein the pulse wave characterizer is configured to acquire the transit time information such that the transit time information describes a duration between a point of a maximum inclination of a first plethysmograph signal and a point of a maximum inclination of a second plethysmograph signal, and to determine the amplitude information such that the amplitude information describes an amplitude of one of the plethysmograph signals;

wherein the pressure value determiner is configured to acquire, as the second pressure value, the systolic blood pressure value on the basis of the transit time information and while using the first mapping; and

wherein the pressure value determiner is configured to acquire, as the first pressure value, a diastolic blood pressure value.

17. The pressure gauge as claimed in claim 1, the pressure gauge being configured to calibrate the first mapping and the second mapping on the basis of a plurality of mutually associated pieces of reference transit time information, reference amplitude information and reference pressure values.

18. The pressure gauge as claimed in claim 1, wherein the pressure gauge comprises a calibrator;

wherein the calibrator is configured to receive a plurality of pieces of reference transit time information which describe transit times of pulse waves between a first location and a second location for a plurality of pressure values, and a plurality of reference pressure values associated with the reference transit time information,

to specify the first mapping while using the reference transit time information and the reference pressure values,

to specify a qualitative course of the second mapping on the basis of the first mapping.

19. The pressure gauge as claimed in claim 18, wherein the calibrator is configured to determine the qualitative course of the second mapping by integrating the first mapping with regard to the pressure value.

20. The pressure gauge as claimed in claim 18, wherein the calibrator is configured to specify a scaling of the second mapping on the basis of information about a difference between two pressure values which describe different phases of the pulsating flow, and on the basis of associated amplitude information describing a change in the measurement signal between the two different phases of the pulsating flow.

21. The pressure gauge as claimed in claim 1, the pressure gauge being configured

to determine or approximate, during a calibration, on the basis of reference pressure values describing a systolic blood pressure and on the basis of associated reference transit time values, a Gaussian pressure/compliance curve which describes a vascular section,

to acquire a sigmoidal pressure/volume curve by integrating the pressure/compliance curve, and

to determine a ratio between amplitude information belonging to the reference blood pressure values and a volume difference as is described by the pressure/volume curve and which corresponds to the amplitude information, as a scaling quantity while using a difference between a systolic reference blood pressure value and an associated diastolic reference blood pressure value.

22. The pressure gauge as claimed in claim 21, the pressure gauge being adapted

to square, during blood pressure measurement, transit time information that is based on a measurement,

to map the result of the squaring to the systolic blood pressure value while using the pressure/compliance curve, and

to acquire a diastolic blood pressure value while using the systolic blood pressure value, the amplitude information and the pressure/volume curve.

23. A method of determining, while using a pressure gauge, pressure values which describe a pressure of a fluid that is flowing in a pulsating manner in at least two phases of the pulsating flow, comprising:

acquiring, by a pulse wave characterizer, transit time information describing a transit time of a pulse wave between a first location and a second location;

acquiring, by the pulse wave characterizer, amplitude information describing a change in a measurement signal, based on the pulse wave, between two phases of the pulse wave;

determining, by a pressure value determiner, a first pressure value, which describes a pressure of the fluid in a first phase of the pulsating fluid, on the basis of the transit time information and while using a first mapping, which maps a transit time of the pulse wave to the first pressure value; and

determining, by the pressure value determiner, a second pressure value, which describes a pressure of the fluid in a second phase of the pulsating flow, on the basis of the first pressure value and of the amplitude information, while using a second mapping, which describes a relationship —

which is dependent on the first pressure value —

between the first pressure value, the second pressure value and the amplitude information, wherein

the second mapping further describes a relationship between an amplitude of the measurement signal and an amplitude of the pulse wave, taking into account the first pressure value,

the second mapping describes a difference between the first pressure value and the second pressure value that is dependent on the amplitude information and on the first pressure value,

the second pressure value represents a systolic pressure value, and

the method is performed by a hardware apparatus, a computer, or a combination of a hardware apparatus and a computer.

24. The method as claimed in claim 23, wherein the second mapping describes a relationship, which is non-linearly dependent on the first pressure value, between the first pressure value, the second pressure value and the amplitude information.

25. A method of calibrating a pressure gauge configured to determine, while using a first mapping and a second mapping, at least one pressure value which describes a pressure of a fluid flowing in a pulsating manner in a phase of the pulsating flow, comprising:

determining, by a pulse wave characterizer, a plurality of pieces of reference transit time information describing transit times of pulse waves between a first location and a second location for a plurality of pressure values, and a plurality of associated reference pressure values;

determining, by a pressure value determiner, the first mapping, which describes a relationship between transit times of the pulse waves and associated pressure values, while using the reference transit time information and the reference pressure values; and

determining, by a pressure value determiner, the second mapping, which describes a relationship, that is dependent on a first pressure value, between the first pressure value, a second pressure value and amplitude information, wherein

a qualitative course of the second mapping is specified on the basis of the first mapping,

the amplitude information describes a change of a measurement signal from a sensor between phases of the pulse waves,

the second mapping describes a difference between the first pressure value and the second pressure value that is dependent on the amplitude information and on the first pressure value,

the second pressure value represents a systolic pressure value, and

the method is performed by a hardware apparatus, a computer, or a combination of a hardware apparatus and a computer.

26. The method as claimed in claim 25, wherein the qualitative course of the second mapping is specified by integrating a course of the first mapping.

27. The method as claimed in claim 25, wherein a mapping parameter describing the second mapping is equal to a mapping parameter (b) describing the first mapping, or

wherein a mapping parameter describing the second mapping is derived from a mapping parameter (b) describing the first mapping.

28. The method as claimed in claim 27, wherein the mapping parameter describes a pressure scaling.

29. The method as claimed in claim 25, wherein the second mapping is determined such that a qualitative course of the second mapping describes a pressure-dependent relationship between local volume values or local volume changes of a fluid conductor within which the pulse wave propagates and associated pressure values or pressure differences.

30. The method as claimed in claim 25, wherein the second mapping is determined such that the second mapping describes a relationship between two pressure values belonging to a pulse wave and an amplitude of a measurement signal created by the pulse wave.

31. The method as claimed in claim 25, wherein a scaling quantity of the second mapping is specified on the basis of at least two reference pressure values and at least two corresponding signal values of a measurement signal.

32. A non-transitory computer-readable medium including a computer program for performing, when the computer program is performed on a computer, a method of determining, while using a pressure gauge, pressure values which describe a pressure of a fluid that is flowing in a pulsating manner in at least two phases of the pulsating flow, the method comprising:

acquiring transit time information describing a transit time of a pulse wave between a first location and a second location;

acquiring amplitude information describing a change in a measurement signal, based on the pulse wave, between two phases of the pulse wave;

determining a first pressure value, which describes a pressure of the fluid in a first phase of the pulsating fluid, on the basis of the transit time information and while using a first mapping, which maps a transit time of the pulse wave to the first pressure value; and

determining a second pressure value, which describes a pressure of the fluid in a second phase of the pulsating flow, on the basis of the first pressure value and of the amplitude information, while using a second mapping, which describes a relationship —

which is dependent on the first pressure value —

between the first pressure value, the second pressure value and the amplitude information, wherein

the second mapping describes a relationship between an amplitude of the measurement signal and an amplitude of the pulse wave, taking into account the first pressure valve,

the second mapping describes a difference between the first pressure value and the second pressure value that is dependent on the amplitude information and on the first pressure value, and

the second pressure value represents a systolic pressure value.

33. A non-transitory computer-readable medium including a computer program for performing, when the computer program is performed on a computer, a method of calibrating a pressure gauge configured to determine, while using a first mapping and a second mapping, at least one pressure value which describes a pressure of a fluid flowing in a pulsating manner in a phase of the pulsating flow, the method comprising:

determining a plurality of pieces of reference transit time information describing transit times of pulse waves between a first location and a second location for a plurality of pressure values, and a plurality of associated reference pressure values;

determining the first mapping, which describes a relationship between transit times of the pulse waves and associated pressure values, while using the reference transit time information and the reference pressure values; and

determining the second mapping, which describes a relationship, that is dependent on a first pressure value, between the first pressure value, a second pressure value and amplitude information,

a qualitative course of the second mapping is specified on the basis of the first mapping,

the amplitude information describes a change of a measurement signal from a sensor between phases of the pulse waves,

the second mapping describes a difference between the first pressure value and the second pressure value that is dependent on the amplitude information and on the first pressure value, and

the second pressure value represents a systolic pressure value.