Pharma-informatics system
First Claim
Patent Images
1. An ingestible device comprising:
- a support;
circuitry associated with the support;
a first material electrically coupled to the circuitry and associated with the support; and
a second material electrically coupled to the circuitry and associated with the support, wherein the first material is electrically isolated from the second material, wherein the first and second materials are selected to provide a voltage potential difference when in contact with an electrically conductive fluid, and wherein the circuitry is configured to modulate current flow through the electrically conductive fluid to generate an encoded monophasic signal which is conductively transmitted to a remote receiver; and
wherein the circuitry comprises a switch; and
wherein the circuitry is configured such that when the switch is closed, a current is produced between the first material and the second material.
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Abstract
Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
824 Citations
20 Claims
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1. An ingestible device comprising:
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a support; circuitry associated with the support; a first material electrically coupled to the circuitry and associated with the support; and a second material electrically coupled to the circuitry and associated with the support, wherein the first material is electrically isolated from the second material, wherein the first and second materials are selected to provide a voltage potential difference when in contact with an electrically conductive fluid, and wherein the circuitry is configured to modulate current flow through the electrically conductive fluid to generate an encoded monophasic signal which is conductively transmitted to a remote receiver; and wherein the circuitry comprises a switch; and wherein the circuitry is configured such that when the switch is closed, a current is produced between the first material and the second material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An ingestible composition comprising:
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(a) a device comprising; (i) a support; (ii) circuitry associated with the support; (iii) a first material electrically coupled to the circuitry; and (iv) a second material electrically coupled to the circuitry, wherein the first material is electrically isolated from the second material, wherein the first and second materials are selected to provide a voltage potential difference when in contact with an electrically conductive fluid, and wherein the circuitry is configured to modulate current flow through the electrically conductive fluid to generate an encoded monophasic signal which is conductively transmitted to a remote receiver; and wherein the circuitry comprises a switch; and wherein the circuitry is configured such that when the switch is closed, a current is produced between the first material and the second material; and (b) a pharmaceutically acceptable carrier. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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20. A method of producing and ingestible device comprising:
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associating circuitry with a support; associating a first material with the support, wherein the first material is electrically coupled to the circuitry; and associating a second material with the support, wherein the second material is electrically coupled to the circuitry, wherein the first material is electrically isolated from the second material, wherein the first and second materials are selected to provide a voltage potential difference when in contact with an electrically conductive fluid, and wherein the circuitry is configured to modulate current flow through the electrically conductive fluid to generate an encoded signal which is conductively transmitted to a remote receiver; and wherein the circuitry comprises a switch; and wherein the circuitry is configured such that when the switch is closed, a current is produced between the first material and the second material.
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Specification