Method for modulation of neuronal activity in the brain by means of sensory stimulation and detection of brain activity

• US 9,119,583 B2
• Filed: 08/20/2013
• Issued: 09/01/2015
• Est. Priority Date: 07/29/2002
• Status: Expired due to Fees

• Current Assignee: Forschungszentrum Jã¼Lich GmbH (Bundesrepublik Deutschland)
• Original Assignee: Forschungszentrum Jã¼Lich GmbH (Bundesrepublik Deutschland)
• Inventors: Tass, Peter A.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US13/971,426
• Publication Number:
  US 20140107525A1
• Time in Patent Office: 742 Days
• Field of Search: 600/544, 607/45, 607/72
• US Class Current: 1/1
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61M 2230/10 Electroencephalographic signals

Abstract

The invention relates to a method for controlled modulation of physiological and pathological neuronal rhythmic activity in the brain by means of sensory stimulation, which is capable of diagnostically ascertaining functional disorders in the brain and of alleviating or eliminating the symptoms of a functional disruption. According to the invention, the method comprises generating a plurality of pulses at a plurality of excitation frequencies, respectively, to stimulate neuronal rhythmic activity in a patient'"'"'s brain; measuring the neuronal rhythmic activity in response to the pulses; determining an excitation frequency in which the measured neuronal rhythmic activity has a maximum amplitude of pathological rhythm; generating an entraining periodic pulse sequence operating at the excitation frequency; and generating a desynchronization pulse following the entraining periodic pulse sequence to desynchronize the neuronal rhythmic activity, where the pulse are either visual or acoustic or tactile.

Claims

1. A method for desynchronizing pathologically rhythmic brain activity, the method comprising:

generating a periodic succession of a plurality of pulses to stimulate neuronal rhythmic activity in a patient'"'"'s brain, wherein a frequency at which the plurality of pulses are generated in the periodic succession is increased from a first limit to a second limit during the periodic succession;

measuring the neuronal rhythmic activity in response to the periodic succession of the plurality of pulses;

determining at least one frequency in which a maximum excitation of the neuronal rhythmic activity is measured in response to the periodic succession of the plurality of pulses;

generating an entraining periodic pulse sequence operating at the at least one frequency to entrain the phase dynamic of the neuronal rhythmic activity; and

generating a desynchronization pulse following the entraining periodic pulse sequence to desynchronize the neuronal rhythmic activity,

wherein the plurality of pulses, the entraining pulse sequence and the desynchronization pulse are either visual or acoustic or tactile.

2. The method according to claim 1, further comprising generating the periodic succession of the plurality of pulses at a frequency range of 1 and 100 Hz.

3. The method according to claim 1, further comprising:

determining the vulnerable phase of the neuronal rhythmic activity; and

generating the desynchronization pulse during the vulnerable phase of the neuronal rhythmic activity.

4. The method according to claim 1, further comprising repeating the steps of generating the entraining periodic pulse sequence and generating the desynchronization pulse after a predetermined time interval.

5. The method according to claim 4, further comprising varying the length of the time interval between the entraining periodic pulse sequence and the desynchronization pulse while monitoring the neuronal rhythmic activity to determine an optimal time interval at which the strongest desynchronization of pathologically rhythmic brain waves of the patient is effected.

6. The method according to claim 4, further comprising:

varying the intensity of each of the repeated desynchronization pulses; and

determining an intensity at which the strongest desynchronization of pathologically rhythmic brain waves is effected.

7. The method according to claim 1, further comprising:

generating a continuous sequence of sensory stimulation after the desynchronization pulse; and

repeating the steps of generating the entraining periodic pulse sequence and generating the desynchronization pulse after the continuous sequence of sensory stimulation.

8. The method according to claim 7, further comprising varying the length of the time interval between the entraining periodic pulse sequence and the desynchronization pulse while monitoring the neuronal rhythmic activity to determine an optimal time interval at which the strongest desynchronization of pathologically rhythmic brain waves of the patient is effected.

9. The method according to claim 7, further comprising:

varying the intensity of each of the repeated desynchronization pulses; and

determining an intensity at which the strongest desynchronization of pathologically rhythmic brain waves is effected.

10. The method according to claim 1, wherein the periodic succession of the plurality of pulses comprises at least 20 pulses.