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Compositions for treatment of attention deficit hyperactivity disorder

  • US 9,119,809 B2
  • Filed: 04/17/2014
  • Issued: 09/01/2015
  • Est. Priority Date: 03/23/2011
  • Status: Active Grant
First Claim
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1. A solid, oral pharmaceutical composition comprising a plurality of particles, each comprising:

  • a core comprising an amphetamine or a pharmaceutical salt thereof and at least one pharmaceutically acceptable excipient;

    a sustained release layer enclosing the core; and

    a delayed release layer enclosing the sustained release layer,wherein when the composition is orally administered to a human subject,(i) there is a lag period of at least 6 hours during which the area under the curve of plasma concentration versus time (AUC0-6) of amphetamine or a pharmaceutical salt thereof is less than 10% of the total area under the curve at Tmax (AUC0-Tmax); and

    (ii) the time to Cmax (Tmax) is between 12 and 19 hours after administration.

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