Morphinan derivatives for the treatment of drug overdose

• US 9,119,848 B2
• Filed: 10/13/2010
• Issued: 09/01/2015
• Est. Priority Date: 12/04/2009
• Status: Active Grant

• Current Assignee: Alkermes Pharma Ireland Limited (Alkermes plc)
• Original Assignee: Alkermes Pharma Ireland Limited (Alkermes plc)
• Inventors: Silverman, Bernard, Fu, Fen-Ni, Guo, Chengyun
• Primary Examiner(s): MCMILLIAN, KARA RENITA
• Application Number:
  US12/903,462
• Publication Number:
  US 20110136848A1
• Time in Patent Office: 1,784 Days
• Field of Search: 514/289, 546/74, 546/75
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/4748 forming part of bridged ring systems strychnine A61K31/475; morphinan derivatives A61K31/485
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: C07D 221/22 Bridged ring systems
• CPC Class Codes: C07D 221/28 Morphinans

Abstract

The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:

Claims

1. A method of treating opioid toxicity or overdose in a subject in need thereof comprising administrating L-malate salt of Compound-1 having the formula:

2. An L-malate salt of compound-1 having the formula: