Probablistic pharmacokinetic and pharmacodynamic modeling
First Claim
Patent Images
1. A system comprising:
- a processor; and
at least one memory, the processor and the at least one memory configured to;
receive dose event data A;
receive observations of therapeutic and wellness data Y; and
determine, based on the received observations of therapeutic and wellness data and the received dose event data, a response H representing a reaction to a substance integrated with an ingestible event marker, according to the following equation;
Y=AH;
wherein Y represents a matrix of observations of therapeutic and wellness data, A represents a matrix of dose event data, and H represents a response matrix.
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Abstract
The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.
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Citations
32 Claims
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1. A system comprising:
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a processor; and at least one memory, the processor and the at least one memory configured to; receive dose event data A; receive observations of therapeutic and wellness data Y; and determine, based on the received observations of therapeutic and wellness data and the received dose event data, a response H representing a reaction to a substance integrated with an ingestible event marker, according to the following equation;
Y=AH;
wherein Y represents a matrix of observations of therapeutic and wellness data, A represents a matrix of dose event data, and H represents a response matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system comprising:
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a processor; at least one memory, the processor and the at least one memory configured to; receive dose event data A; receive observations of therapeutic and wellness data Y; and determine, based on the received observations of therapeutic and wellness data and the received dose event data, a response H representing a reaction to a substance integrated with an ingestible event marker, according to the following equation;
Y=AH;
wherein Y represents a matrix of observations of therapeutic and wellness data, A represents a matrix of dose event data, and H represents a response matrix; and a therapy controller to control, based on the response data and the therapeutic and wellness data, at least one of a dose of the substance and a time of the dose of the substance. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A method comprising:
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receiving, by a processor and at least one memory coupled to the processor, dose event data A; receiving, by the processor and the at least one memory coupled to the processor, observations of therapeutic and wellness data Y; and determining, by the processor and the at least one memory coupled to the processor, based on the received observations of therapeutic and wellness data and the received dose event data, a response H representing a reaction to a substance integrated with an ingestible event marker, according to the following equation;
Y=AH;
wherein Y represents a matrix of observations of therapeutic and wellness data, A represents a matrix of dose event data, and H represents a response matrix. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method comprising:
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receiving, by a processor and at least one memory coupled to the processor, dose event data A; receiving, by the processor and the at least one memory, observations of therapeutic and wellness data Y; and determining, by the processor and the at least one memory, based on the received observations of therapeutic and wellness data and the received dose event data, a response H representing a reaction to a substance integrated with an ingestible event marker, according to the following equation;
Y=A H;
wherein Y represents a matrix of observations of therapeutic and wellness data, A represents a matrix of dose event data, and H represents a response matrix; and controlling, by a therapy controller coupled to the processor and the at least one memory, at least one of a dose of the substance and a time of the dose of the substance based on the response data and the therapeutic and wellness data. - View Dependent Claims (28, 29, 30, 31, 32)
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Specification