Implant device release agents and methods of using same
First Claim
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1. A device suitable for implantation into a subject for delivery of an active agent to the subject at a zero-order or near-zero order rate comprising:
- a polymeric material comprising a polymer formed from one or more hydrophilic, ethylenically unsaturated monomers and a release agent;
wherein the device is a molded, reservoir implant comprising a hollow core for containing the active agent and an optional pharmaceutical carrier; and
the release agent comprises d-α
-tocopheryl polyethylene glycol 1000 succinate (Vitamin E TPGS).
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Abstract
Medical implant devices are prepared from a polymeric material and a release agent, where the device is a molded, reservoir implant, and the release agent has a molecular weight (MW) of at least 1000. The release agent may be a non-ionic surfactant such as Brij 35, polyoxyetheylene(20)sorbitan trioleate, Tween 20, Tween 80, vitamin E TPGS, and a mixture of any two or more thereof. Hydrated implants may have a surface area of about 500 mm2 or greater.
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Citations
20 Claims
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1. A device suitable for implantation into a subject for delivery of an active agent to the subject at a zero-order or near-zero order rate comprising:
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a polymeric material comprising a polymer formed from one or more hydrophilic, ethylenically unsaturated monomers and a release agent; wherein the device is a molded, reservoir implant comprising a hollow core for containing the active agent and an optional pharmaceutical carrier; and the release agent comprises d-α
-tocopheryl polyethylene glycol 1000 succinate (Vitamin E TPGS). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A process comprising:
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charging a polymerization column or a mold with a liquid comprising one or more hydrophilic, ethylenically unsaturated monomers and a release agent; rotating the polymerization column or mold about its longitudinal axis at a speed sufficient to displace the monomer radially outward along the interior surfaces of the polymerization column or mold; maintaining the polymerization column or mold at a position substantially parallel to the ground; polymerizing the liquid polymerizable material; and recovering a reservoir implant device; wherein the release agent is Vitamin E TPGS. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification