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Biologic compounds directed against death receptor 5

  • US 9,120,855 B2
  • Filed: 02/09/2011
  • Issued: 09/01/2015
  • Est. Priority Date: 02/10/2010
  • Status: Expired due to Fees
First Claim
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1. An isolated polypeptide comprising at least one monomer of a single variable domain comprising the sequence of the complementarity determining region 3 (CDR3) sequence of SEQ ID NO:

  • 66, the sequence of the complementarity determining region 2 (CDR2) sequence of SEQ ID NO;

    53, and the sequence of the complementarity determining region 1 (CDR1) sequence of SEQ ID NO;

    43, wherein the isolated polypeptide specifically binds to human DR5.

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