Devices and methods for control of blood pressure

• US 9,125,732 B2
• Filed: 02/18/2011
• Issued: 09/08/2015
• Est. Priority Date: 07/25/2005
• Status: Active Grant

• Current Assignee: Vascular Dynamics Inc.
• Original Assignee: Vascular Dynamics Inc.
• Inventors: Gross, Yossi, Avneri, Itzik, Weisberg, Ori, Eshkol, Moshe
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): WOLF, MEGAN YARNALL
• Application Number:
  US13/030,384
• Publication Number:
  US 20110178416A1
• Time in Patent Office: 1,663 Days
• Field of Search: 623/1.15, 623/1.24, 623/1.26
• US Class Current: 1/1
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/825 having longitudinal struts
• CPC Class Codes: A61F 2230/0019 rectangular
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: A61N 1/36117 for treating hypertension

Abstract

Apparatus and methods are described including an implantable device shaped to define (a) at least two artery-contact regions, the artery-contact regions comprising struts that are configured to stretch an arterial wall by applying pressure to the arterial wall, and (b) at least two crimping regions that comprise locking mechanisms configured to prevent the crimping regions from becoming crimped due to pressure from the wall of the artery on the artery-contact regions. The crimping regions are configured to be crimped during insertion of the device, via a catheter, by the locking mechanisms being unlocked during insertion of the device. Other embodiments are also described.

Claims

1. A method, comprising:

inserting into an artery of a subject, via a catheter, an implantable device that is shaped to define;

at least four artery-contact regions, the artery-contact regions comprising at least four longitudinal struts, and

at least two crimping regions each comprising a locking mechanism comprising a crimping arch disposed at an end of at least one of the artery-contact regions, the locking mechanism comprising the crimping arch being configured to prevent the crimping regions from becoming crimped due to pressure from the wall of the artery on the artery-contact regions,

the insertion being performed by crimping the crimping regions about the crimping arch during insertion of the device, the locking mechanism unlocked during insertion of the device via the catheter;

advancing the device out of a distal end of the catheter; and

upon advancing the device out of the distal end of the catheter, stretching a wall of the artery by applying pressure to the arterial wall with the at least four longitudinal struts and by locking the locking mechanism in order to flatten at least four regions of an arterial wall and change the shape of the arterial wall such that the arterial wall has a rectangular cross-sectional shape to modulate baroreceptor activity.

2. The method according to claim 1, wherein the crimping arch has a radius of curvature of less than 0.6 mm to resist pressure from the wall of the artery.

3. The method according to claim 2, wherein the crimping arch has a radius of curvature of more than 0.3 mm.

4. The method according to claim 2, wherein inserting the device comprises inserting the device, struts of the at least four artery-contact regions of the device projecting outwardly from the crimping arch at an angle that is greater than 30 degrees.

5. The method according to claim 4, wherein inserting the device comprises inserting the device, the struts of the at least four artery-contact regions of the device projecting outwardly from the crimping arch at an angle that is greater than 60 degrees.

6. The method according to claim 5, wherein inserting the device comprises inserting the device, the struts of the at least four artery-contact regions of the device projecting outwardly from the crimping arch at an angle that is greater than 60 degrees.

7. The method according to claim 1, wherein inserting the device comprises inserting the device, a maximum span of the device increasing along a direction of a longitudinal axis of the device from a first end of the device to a second end of the device.

8. The method according to claim 7, wherein inserting the device comprises placing the device such that the second end of the device is placed in a carotid sinus of the subject, and the first end of the device is placed in an internal carotid artery of the subject.

9. The method according to claim 7, wherein inserting the device comprises inserting the device, a ratio of the maximum span of the device at the second end of the device to the maximum span of the device at the first end of the device being between 1.1:

1 and 2;

1.

10. The method according to claim 9, wherein inserting the device comprises inserting the device, a ratio of the maximum span of the device at the second end of the device to the maximum span of the device at the first end of the device is between 1.1:

1 and 1.4;

1.

11. The method according to claim 1, wherein inserting the device comprises inserting the device, the artery-contact regions of the device each comprising two or more struts that are longitudinally translated with respect to one another.

12. The method according to claim 11, wherein inserting the device comprises inserting the device, the device including a reinforcing element configured to couple the two or more struts to one another, and to maintain the longitudinal translation of the struts with respect to one another when the device is crimped.

13. The method, according to claim 1, wherein inserting the device comprises inserting the device having a total cross-sectional area of less than 5 sq mm.

14. The method according to claim 13, wherein inserting the device comprises inserting the device having a total cross-sectional area of less than 0.5 sq mm.

15. The method according to claim 1, wherein the thickness of the crimping arch is greater than the thickness of the struts of the artery-contact regions to facilitate resistance to pressure exerted from the wall of the artery on the artery-contact regions.