Ionic silicone hydrogels
First Claim
1. A silicone hydrogel comprising at least one pharmaceutical or nutraceutical component wherein said silicone hydrogel is formed from a reaction mixture comprisingabout 37 to about 75 wt % of a mixture of slow-reacting hydrophilic monomers, each having a slow-reacting hydrophilic monomer kinetic half life;
- said mixture of slow reacting hydrophilic monomers comprising at least one slow-reacting ionic monomer;
at least one silicone-containing component having a silicone-containing component kinetic half life, which may be optionally substituted with at least one hydroxyl containing group; and
at least one hydroxyl-containing component selected from said silicone-containing components substituted with at least one hydroxyl containing group, at least one hydroxyalkyl monomer, and mixtures thereof,wherein ratio of each of said slow-reacting hydrophilic component half lives to said silicone-containing component half life is at least 2.
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Abstract
The present invention relates to ionic silicone hydrogel contact lenses which comprise at least one pharmaceutical or nutriceutical component and are formed from reaction mixtures comprising a mixture of slow-reacting hydrophilic monomers, including at least one slow-reacting ionic monomer, at least one silicone-containing component and at least one hydroxyl-containing component, wherein the ratio of the slow-reacting hydrophilic component half lives to the silicone-containing component half life is at least 2.
120 Citations
92 Claims
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1. A silicone hydrogel comprising at least one pharmaceutical or nutraceutical component wherein said silicone hydrogel is formed from a reaction mixture comprising
about 37 to about 75 wt % of a mixture of slow-reacting hydrophilic monomers, each having a slow-reacting hydrophilic monomer kinetic half life; - said mixture of slow reacting hydrophilic monomers comprising at least one slow-reacting ionic monomer;
at least one silicone-containing component having a silicone-containing component kinetic half life, which may be optionally substituted with at least one hydroxyl containing group; and at least one hydroxyl-containing component selected from said silicone-containing components substituted with at least one hydroxyl containing group, at least one hydroxyalkyl monomer, and mixtures thereof, wherein ratio of each of said slow-reacting hydrophilic component half lives to said silicone-containing component half life is at least 2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92)
- said mixture of slow reacting hydrophilic monomers comprising at least one slow-reacting ionic monomer;
Specification