Use of botulinum neurotoxin to treat substance addictions
First Claim
1. A method of treating a substance addiction-related behavior in a patient, comprisingadministering by a non-systemic route a therapeutically effective dose of a botulinum neurotoxin to a location on the patient'"'"'s body which comes into contact with a smoking tool or addictive substance,wherein the location is selected from the group consisting of:
- thumb, index finger, middle finger and a combination thereof, thereby altering peripheral sensation of the body location,wherein said therapeutically effective dose is sufficient to inhibit a sensory output from a muscle to the central nervous system such that generation of a premonitory urge or motor output associated with the substance addiction-related behavior in the body location is reduced but is less than a dose necessary to produce a substantial muscle weakness within the affected location.
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Abstract
The present invention provides methods for treating a substance addiction-related behavior in a patient with a substance addiction, comprising the step of locally administering a therapeutically effective amount of a botulinum neurotoxin to a location on the patient'"'"'s body or in the vicinity of the area which comes into contact with a smoking tool or addictive substance, thereby altering, reducing or eliminating sensations associated with behaviors associated with substance addiction. Botulinum neurotoxin may be administered to a dermal, subdermal, mucosal or submucosal location or to a muscle area or in the vicinity of the location to which a smoking tool or addictive substance contacts.
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Citations
19 Claims
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1. A method of treating a substance addiction-related behavior in a patient, comprising
administering by a non-systemic route a therapeutically effective dose of a botulinum neurotoxin to a location on the patient'"'"'s body which comes into contact with a smoking tool or addictive substance, wherein the location is selected from the group consisting of: - thumb, index finger, middle finger and a combination thereof, thereby altering peripheral sensation of the body location,
wherein said therapeutically effective dose is sufficient to inhibit a sensory output from a muscle to the central nervous system such that generation of a premonitory urge or motor output associated with the substance addiction-related behavior in the body location is reduced but is less than a dose necessary to produce a substantial muscle weakness within the affected location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- thumb, index finger, middle finger and a combination thereof, thereby altering peripheral sensation of the body location,
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19. A method of treating a substance addiction-related behavior in a patient, comprising
administering by a non-systemic route a therapeutically effective dose of a botulinum neurotoxin to the nasal cavity of the patient'"'"'s body which comes into contact with a smoking tool or addictive substance thereby altering peripheral sensation of the body location, wherein said therapeutically effective dose is sufficient to inhibit a sensory output from a muscle to the central nervous system such that generation of a premonitory urge or motor output associated with the substance addiction-related behavior in the body location is reduced but is less than a dose necessary to produce a substantial muscle weakness within the affected location.
Specification