Fluorapatite glass-ceramics

• US 9,125,967 B2
• Filed: 11/08/2013
• Issued: 09/08/2015
• Est. Priority Date: 11/13/2012
• Status: Expired due to Fees

• Current Assignee: University of Iowa Research Foundation
• Original Assignee: University of Iowa Research Foundation
• Inventors: Denry, Isabelle, Holloway, Julie
• Primary Examiner(s): WIESE, NOAH S
• Application Number:
  US14/075,754
• Publication Number:
  US 20140271565A1
• Time in Patent Office: 669 Days
• Field of Search: 501/3
• US Class Current: 1/1
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 27/105 containing Al2O3
• CPC Class Codes: A61L 27/3834 Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells

Abstract

The present invention provides a highly-sintered fluorapatite glass-ceramic comprising a high Ca/Al or Sr/Al mole-ratio, that possesses a microstructure that induces apatite/bone deposition.

Claims

1. A fluorapatite glass-ceramic body prepared by a process comprising:

(a) providing powdered glass by heating a SiO₂—

Al₂O₃—

P₂O₅—

MgO—

Na₂O—

K₂O—

CaO—

CaF₂ mixture having a CaO;

Al₂O₃ mole-ratio of about 2.5-30;

1;

(b) compacting the powdered glass into a solid form; and

(c) heating the solid form to about 650-1050°

C. for a time sufficient to yield a sintered fluorapatite glass-ceramic body.

3. The body of claim 1 wherein SrO is absent.

6. The body of claim 1 or 2 wherein step (c) is carried out at about 700°

C.-900°

C.

7. The body of claim 1 or 2 wherein the degree of sintering in step (c) is about 90-99.5%.

8. The body of claim 1 wherein the CaO:

Al₂O₃ mole-ratio is about 3-25;

1.

10. The body of claim 3 wherein the solid form is sintered at about 750-800°

C.

11. The body of claim 10 wherein the heating is carried out for about 0.25-5.0 hrs.

12. The body of claim 1 or 2 wherein the glass comprises niobium.

13. The body of claim 1 that comprises flower-shaped fluorapatite crystals substantially as shown in FIG. 4, Panels C or D.

14. The body of claim 1 wherein the fluorapatite glass of step (a) is prepared by melting a mixture of the composition:

15. The body of claim 14 further comprising SrO.

16. The body of claim 1 wherein the fluorapatite glass of step (a) is prepared by melting a composition of the formulas C-D:

17. The body of claim 16 wherein the solid form prepared from composition C is heated at about 700°

C.-900°

C. or the solid form prepared from composition D is heated at about 775°

C.-950°

C.

19. The body of claim 1 or 2 further comprising stem cells cultured thereupon.

20. The body of claim 19 wherein the stem cells are hMSCs.

21. A therapeutic method comprising implanting a shaped body of claim 1 or 2 in vivo in an amount effective to stimulate bone growth in a mammal.

22. The method of claim 21 wherein the mammal is a human.

23. The glass of step (a) of claim 1 or 2.

24. A bone filler, bone replacement material or bone graft material formed from the fluorapatite glass-ceramic body of claim 1 or 2.

25. A glass-ceramic scaffold formed from the fluorapatite glass-ceramic body of claim 1 or 2.

2. A fluorapatite glass-ceramic body prepared by a process comprising:

(a) producing powdered glass by heating a mixture of SiO₂—

Al₂O₃—

P₂O₅—

MgO—

Na₂O—

K₂O—

CaF₂, comprising SrO or a combination of CaO and SrO having a mole ratio of SrO to Al₂O₃ of about 2.5-30;

1;

(b) compacting the powdered glass into a solid firm; and

(c) heating the solid form to about 650°

C.-1050°

C. for a time sufficient to yield a sintered fluorapatite glass-ceramic body.

4. The body of claim 2 wherein both SrO and CaO are present.

5. The body of claim 2 wherein CaO is absent and SrO is present.

9. The body of claim 2 wherein the SrO:

CaO mole ratio is about 3-1;

1.

18. The body of claim 2 wherein the fluorapatite glass of step (a) is prepared by melting a composition of the formulas E-G: