Amido compounds and their use as pharmaceuticals

• US 9,126,927 B2
• Filed: 09/23/2011
• Issued: 09/08/2015
• Est. Priority Date: 05/07/2004
• Status: Active Grant

• Current Assignee: Incyte Corporation, Incyte Holdings Corporation (Incyte Corporation), Incyte Holdings Corporation And Incyte Corporation
• Original Assignee: Incyte Corporation, Incyte Holdings Corporation (Incyte Corporation)
• Inventors: Yao, Wenqing, Zhuo, Jincong, Metcalf, Brian W., Qian, Ding-Quan, Zhang, Colin, Xu, Meizhong, He, Chunhong
• Primary Examiner(s): KOSACK, JOSEPH R
• Application Number:
  US13/243,565
• Publication Number:
  US 20120015928A1
• Time in Patent Office: 1,446 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/407 condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61P 11/04 for throat disorders
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/48 of the pancreatic hormones
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 : Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 : Antihypertensives
• CPC Class Codes: A61P 9/14 : Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
• CPC Class Codes: C07D 207/06 : with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
• CPC Class Codes: C07D 207/08 : with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
• CPC Class Codes: C07D 207/10 : with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 207/12 : Oxygen or sulfur atoms
• CPC Class Codes: C07D 207/14 : Nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 207/16 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 207/27 : with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 209/08 : with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 209/42 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 209/44 : Iso-indoles; Hydrogenated iso-indoles
• CPC Class Codes: C07D 209/52 : condensed with a ring other than six-membered
• CPC Class Codes: C07D 209/62 : Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
• CPC Class Codes: C07D 209/70 : containing carbocyclic rings other than six-membered
• CPC Class Codes: C07D 211/16 : with acylated ring nitrogen atom
• CPC Class Codes: C07D 211/18 : with substituted hydrocarbon radicals attached to ring carbon atoms
• CPC Class Codes: C07D 211/22 : by oxygen atoms
• CPC Class Codes: C07D 211/34 : with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 211/46 : having a hydrogen atom as the second substituent in position 4
• CPC Class Codes: C07D 211/48 : having an acyclic carbon atom attached in position 4
• CPC Class Codes: C07D 211/52 : having an aryl radical as the second substituent in position 4
• CPC Class Codes: C07D 211/58 : attached in position 4
• CPC Class Codes: C07D 211/64 : having an aryl radical as the second substituent in position 4
• CPC Class Codes: C07D 211/66 : having a hetero atom as the second substituent in position 4
• CPC Class Codes: C07D 211/70 : with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 213/38 : having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
• CPC Class Codes: C07D 217/06 : with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
• CPC Class Codes: C07D 217/26 : Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 221/20 : Spiro-condensed ring systems
• CPC Class Codes: C07D 295/185 : from aliphatic carboxylic acids
• CPC Class Codes: C07D 333/34 : Sulfur atoms
• CPC Class Codes: C07D 401/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/06 : linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 401/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 401/14 : containing three or more hetero rings
• CPC Class Codes: C07D 403/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/14 : containing three or more hetero rings
• CPC Class Codes: C07D 413/10 : linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 413/14 : containing three or more hetero rings
• CPC Class Codes: C07D 417/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07D 471/10 : Spiro-condensed systems
• CPC Class Codes: C07D 487/04 : Ortho-condensed systems
• CPC Class Codes: C07D 487/08 : Bridged systems
• CPC Class Codes: C07D 487/10 : Spiro-condensed systems
• CPC Class Codes: C07D 491/10 : Spiro-condensed systems
• CPC Class Codes: C07D 491/107 : with only one oxygen atom as ring hetero atom in the oxygen-containing ring
• CPC Class Codes: C07D 491/20 : Spiro-condensed systems
• CPC Class Codes: C07D 493/10 : Spiro-condensed systems
• CPC Class Codes: C07D 495/04 : Ortho-condensed systems
• CPC Class Codes: C07D 498/20 : Spiro-condensed systems
• CPC Class Codes: C07D 513/10 : Spiro-condensed systems

Abstract

The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

Claims

1. A compound of Formula Va:

2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Cy is aryl or heteroaryl, each optionally substituted by 1, 2, 3, 4 or 5 —

W—

X—

Y—

Z.

3. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Cy is aryl optionally substituted by 1, 2, 3, 4 or 5 —

W—

X—

Y—

Z.

4. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Cy is aryl optionally substituted by 1, 2 or 3 substituents independently selected from halo, C_1-4 alkyl, C_1-4 alkoxy, C_1-4 haloalkyl, and C_1-4 haloalkoxy.

5. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein Cy is phenyl optionally substituted by 1, 2 or 3 substituents independently selected from halo, C_1-4 alkyl, C_1-4 alkoxy, C_1-4 haloalkyl, and C_1-4 haloalkoxy.

6. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R¹ and R² together with the C atom to which they are attached form a 3-, 4-, 5-, 6- or 7-membered cycloalkyl group.

7. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R¹ and R² together with the C atom to which they are attached form a cyclopropyl group.

8. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein —

W—

X—

Y—

Z is halo, cyano, C_1-4 cyanoalkyl, nitro, C_1-8 alkyl, C_2-8 alkenyl, C_1-8 haloalkyl, C_1-4 alkylthio, C_1-4 haloalkylthio, C_1-8 alkoxy, C_2-8 alkenyloxy, C_1-4 haloalkoxy, OH, (C_1-4 alkoxy)-C_1-4 alkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, OC(O)NR^cR^d, NR^cC(O)R^d, NR^cC(O)OR^a, NR^cS(O)₂R^d, C(O)OR^a, C(O)R^a, C(O)NR^aNR^cR^d, S(O)₂R^d, SR^d, C(O)NR^cR^d, C(S)NR^cR^d, aryloxy, heteroaryloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, arylalkyloxy, heteroarylalkyloxy, cycloalkylalkyloxy, heterocycloalkylalkyloxy, heteroaryloxyalkyl, aryloxyalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl , heteroarylalkynyl, cycloalkylalkyl, or heterocycloalkylalkyl;

wherein each of said C_1-8 alkyl, C_2-8 alkenyl, C_1-8 haloalkyl, C_1-4 alkylthio, C_1-4 haloalkylthio, C_1-8 alkoxy, aryloxy, heteroaryloxy, arylalkyloxy, heteroarylalkyloxy, heteroaryloxyalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, cycloalkenyloxy, heterocycloalkyloxy, arylalkyloxy, heteroarylalkyloxy, cycloalkylalkyloxy, heterocycloalkylalkyloxy, heteroaryloxyalkyl, aryloxyalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl , heteroarylalkynyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted by 1, 2, or 3 substituents independently selected from halo, cyano, nitro, hydroxyl-(C_1-6 alkyl), aminoalkyl, dialkylaminoalkyl, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 cyanoalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, OH, OR^a, (C_1-4 alkoxy)-C_1-4 alkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, C(O)NR^cR^d, C(O)OR^a, C(O)R^a, (cyclocalkylalkyl)-C(O)—

, NR^cC(O)R^d, NR^cC(O)OR^a, NR^cS(O)₂R^d, C(S)NR^cR^d, S(O)₂R^d, SR^d, (C_1-4 alkyl)sulfonyl, arylsulfonyl, aryl optionally substituted by halo, heteroaryl, cycloalkylalkyl, cycloalkyl, and heterocycloalkyl.

9. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein —

W—

X—

Y—

Z is halo, cyano, C_1-4 cyanoalkyl, nitro, C_1-8 alkyl, C_2-8 alkenyl, C_1-8 haloalkyl, C_1-10 alkoxy, C_1-4 haloalkoxy, OH, C_1-8 alkoxyalkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, OC(O)NR^cR^d, NR^cC(O)R^d, NR^cC(O)OR^al , aryloxy, heteroaryloxy, arylalkyloxy, heteroarylalkyloxy, heteroaryloxyalkyl, aryloxyalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl , heteroarylalkynyl, cycloalkylalkyl, or heterocycloalkylalkyl;

wherein each of said C_1-8 alkyl, C_2-8 alkenyl, C_1-8 haloalkyl, C_1-8 alkoxy, aryloxy, heteroaryloxy, arylalkyloxy, heteroarylalkyloxy, heteroaryloxyalkyl, aryloxyalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl , heteroarylalkynyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted by 1, 2, or 3 substituents independently selected from halo, cyano, nitro, hydroxyl-(C_{1- 6} alkyl), aminoalkyl, dialkylaminoalkyl, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, OH, C_1-8 alkoxyalkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, C(O)NR_cR^d, C(O)OR^a, NR^cC(O)R^d, NR^cS(O)₂R^d, (C_1-4 alkyl)sulfonyl, arylsulfonyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl.

10. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein —

W—

X—

Y—

Z is halo, cyano, C_1-4 cyanoalkyl, nitro, C_1-4 nitroalkyl, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, OH, (C_1-4 alkoxy)-C_1-4 alkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl.

11. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein —

W—

X—

Y—

Z is halo, C_1-4 alkyl, or C_1-4 alkoxy.

12. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein:

—

W′

—

x′

—

y′

—

Z′

is halo, OH, cyano, CHO, COOH, C(O)O—

(C_1-4 alkyl), C(O)—

(C_1-4 alkyl), SO₂-(C_1-4 alkyl), C_1-4 alkyl, C_1-4 alkoxy or -L-R⁷, wherein said C_1-4 alkyl or C_1-4 alkoxy is optionally substituted by one or more halo, OH, COOH or C(O)O—

(C_1-4 alkyl);

L is absent, O, CH₂, NHSO₂, N[C(O)—

(C_1-4 alkyl)]; and

R⁷ is aryl or heteroaryl, each is optionally substituted by 1, 2, or 3 substituents independently selected from halo, OH, cyano, CHO, COOH, C(O)O—

(C_1-4 alkyl), C(O)—

(C_1-4 alkyl), SO₂—

(C_1-4 alkyl), SO₂—

NH(C_1-4 alkyl), C_1-4 alkyl, C_1-4 alkoxy, C_1-4 haloalkyl, C_1-4 hydroxyalkyl, aryl, heteroaryl and aryloxy.

13. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein —

W′

—

X′

—

Y′

—

Z′

is halo;

C_1-4 alkyl;

C_1-4 haloalkyl;

OH;

C_1-4 alkoxy;

C_1-4 haloalkoxy;

hydroxyalkyl;

alkoxyalkyl;

aryl;

heteroaryl;

aryl substituted by halo, C_1-4 alkyl, C_1-4 alkoxy, aryl, heteroaryl, or aryloxy;

or heteroaryl substituted by halo, C_1-4 alkyl, C_1-4 alkoxy, aryl, or heteroaryl.

14. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein —

W″

—

X″

—

Y″

—

Z″

is halo, cyano, C_1-4 cyanoalkyl, nitro, C_1-4 nitroalkyl, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, OH, (C_1-4 alkoxy)-C_1-4 alkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl.

15. A compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein

Z, Z′

and Z″

are each, independently, H, halo, CN, NO₂, OH, C_1-4 alkoxy, C_1-4 haloalkoxy, amino, C_1-4 alkylamino or C_2-8 dialkylamino, C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl, wherein said C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl is optionally substituted by 1, 2 or 3 substituents independently selected from halo, C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO₂, OR^a, SR^a, C(O)R^b, C(O)NR_cR^d, C(O)OR^a, OC(O)R^b, OC(O)NR^cR^d, NR^cR^d, NR^cC(O)R^d, NR^cC(O)OR^a, S(O)R^b, S(O)NR^cR^d, S(O)₂R^b, and S(O)₂NR^cR^d.

16. A compound of claim 1, or a pharmaceutically acceptable salt thereof, having Formula VI:

17. A compound of claim 16, or a pharmaceutically acceptable salt thereof, having Formula VII:

18. A compound of claim 17, or a pharmaceutically acceptable salt thereof, having Formula VIII:

27. A method of treating a disease in a patient, wherein said disease is obesity, diabetes, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hyperlipidemia, glaucoma, osteoporosis, or inflammation, comprising administering to said patient a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

28. A method of treating a disease in a patient, wherein said disease is hypertension, a renal disease, inflammation, atherosclerosis, arteriosclerosis, coronary artery disease, thrombosis, angina, peripheral vascular disease, vascular wall damage, stroke, dyslipidemia, hyperlipoproteinaemia, diabetic dyslipidemia, mixed dyslipidemia, hypercholesterolemia, hypertriglyceridemia, type 1 diabetes, type 2 diabetes, obesity, metabolic syndrome, insulin resistance or general aldosterone-related target organ damage, comprising administering to said patient a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

29. A composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

30. A method of treating type 2 diabetes in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

31. A method of treating type 2 diabetes in a patient, comprising administering to said patient a therapeutically effective amount of a compound according to claim 1 of formula VIII:

32. A method of treating type 2 diabetes in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 1, wherein the compound is a compound of formula VIII:

33. A method according to claim 32, or a pharmaceutically acceptable salt thereof, wherein —

W—

X—

Y—

Z is halo, cyano, C_1-4 cyanoalkyl, nitro, C_1-4 nitroalkyl, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, OH, (C_1-4 alkoxy)-C_1-4 alkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl;

wherein each of said aryl and heteroaryl, is optionally substituted by 1, 2, or 3 substituents independently selected from halo, cyano, nitro, hydroxyl-(C_1-6 alkyl), aminoalkyl, dialkylaminoalkyl, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, OH, C_1-8 alkoxyalkyl, amino, C_1-4 alkylamino, C_2-8 dialkylamino, C(O)NR^cR^d, C(O)OR^a, NR^cC(O)R^d, NR^cS(O)₂R^d, (C_1-4 alkyl)sulfonyl, arylsulfonyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl.

19. A compound selected from:

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-2,3-dihydrospiro[indene-1,4′

-piperidine];

1′

-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-1-methylspiro[indole-3,4′

-piperidin]-2(1H)-one;

tert-Butyl 1′

-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}spiro[indole-3,4′

-piperidine]-1(2H)-carboxylate;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-2,3-dihydro-1H-spiro[isoquinoline-4,4′

-piperidine];

tert-Butyl 1′

-{[1-(4- chlorophenyl)cyclopropyl]carbonyl}-1H-spiro[isoquinoline-4,4′

-piperidine]-2(3H)-carboxylate;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,4′

-piperidine];

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[indole-3 ,4′

-piperidin]-2(1H)-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[1 ,2-benzisothiazole-3,3′

-pyrrolidine]-1,1-dioxide;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-2-yloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidine];

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-1H-spiro[furo[3,4-c]pyridine-3 ,3′

-pyrrolidin]-1-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[indole-3,3′

-pyrrolidin]-2(1H)-one;

1′

-({1-[4-(1H-Pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Difluoromethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyrrolidin-1-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyrrolidin-1-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Pyrrolidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Pyrrolidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Phenylethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(1-Methylcyclopropyl)methoxy]phenyl}cyclopropyl)-carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(2-Fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-2-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(3-Fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1,3-Benzothiazol-2-ylmethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-{[3 ,5-Bis(trifluoromethyl)benzyl]oxy}phenyl)-cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[2-(4-Fluorophenyl)ethoxy]phenyl}cyclopropyl)-carb onyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-[(4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)methyl]benzonitrile;

1′

-{[1-(4-Phenoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-4-ylmethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-2-ylmethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyridin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Cyclopropylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Fluoro-4-pyridin-2-ylphenyl)cyclopropyl]-carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-(4-Methylphenyl)vinyl]phenyl}-cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-2-ylethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-2-ylethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-Pyridin-4-ylvinyl]phenyl}cyclopropyl)-carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3 ,5-Dimethylisoxazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4′

-(Methylsulfonyl)biphenyl-4-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2H-Indazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Benzimidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methyl-1H-imidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-1 ,2,4-Triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclopentyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Cyclopentylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclopentyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclobutyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclobutyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Tetrahydro-2H-pyran-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Cyclobutylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Hydroxytetrahydro-2H-pyran-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Hydroxytetrahydro-2H-pyran-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Ethyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1,3-Thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[trans-1-(4-Chlorophenyl)-3-hydroxycyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidine];

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(1H-Indazol-1-yl)phenyl]cyclobutyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclobutyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Benzimidazol-1-yl)phenyl]cyclobutyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclobutyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-4-ylcyclobutyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyridin-4-ylphenyl)cyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N,N-Dimethyl-4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxamide;

1′

-[(1-{6-[4-(Methylsulfonyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(2-Fluorophenyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3 ,3-Difluoropyrrolidin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-Hydroxypyrrolidin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-{1-[5-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]pyrrolidin-3-yl}acetamide;

1′

-({1 4641,3-Dihydro-2H-isoindol -2-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3,4-Dihydro-isoquinolin-2(1H)-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Morpholin-4-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Hydroxypiperidin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-{4-[5-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]phenyl}acetamide;

1′

-({1-[6-(2-Fluorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Benzothien-3-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,3′

-Bipyridin-5-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-indo1-5-yl)pyridine-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethoxy)phenyl]pyridine-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3-Thienyl)pyridine-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethyl)phenyl]pyridine-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-pyrazol-4-yl)pyridine-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Chloropyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(Benzyloxy)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-3-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-pyrazol-4-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(Benzyloxy)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Chloropyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3,4-Dihydroisoquinolin-2(1H)-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1 4641,3-Dihydro-2H-isoindol -2-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3 ,3-Difluoropyrrolidin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Isobutyl 4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazine-1-carboxylate;

2-[4-(5-{1-[(3-Oxo-1′

H,3H-spiro[faro[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazin-1-yl]benzonitrile;

1′

-[(1-{6-[4-(4-Fluorophenyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethoxy)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-(5-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)benzonitrile;

1′

-({1 4643-Chloro-4-fluorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(Methoxymethyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

N-[3-(5-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)phenyl]acetamide;

4-(5-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)benzamide;

1′

-[(1-{6-[4-(Methylsulfonyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-indo1-5-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Benzothien-5-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Quinolin-3-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3-Thienyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-2,3-dihydro-1H-indol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}benzonitrile;

4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}benzenecarbothioamide;

1′

-[(1-{4-[1-(Methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-Pyridin-4-ylvinyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[Cyclopentyl(fluoro)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Tetrahydro-2H-pyran-4-yloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

tert-Butyl (4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)acetate;

(4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)acetonitrile;

1′

-[(1-{4-[(5-Methylisoxazol-3-yl)methoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Cyclopentylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-3-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-4-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-6-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-3-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-(Trifluoromethyl)-1′

-({1-[4-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Trifluoromethoxy)phenyl]cyclopropyl}carbonyl)-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Difluorophenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[141,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Fluoro-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4-fluoro-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

7-Fluoro-1′

-[(1-{4-[(trifluoromethyl)thio]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Bromophenyl)cyclopropyl]carbonyl}-7-fluoro-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-6-chloro-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[4-(trifluoromethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(2-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzonitrile;

1′

-{[1-(3-(Hydroxymethyl)phenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Bromophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyrrolidin-1-ylcarbonyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzohydrazide;

N-Methyl-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzamide;

4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzenecarbothioamide;

1′

-[(1-{4-[2-(Trifluoromethyl)-1H-imidazol-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Methyl-1H-pyrazol-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Cyclopropyl-4′

-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)biphenyl-4-carboxamide;

1′

-[(1-{4-[5-(Trifluoromethyl)-1H-1 ,2,4-triazol-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-tetrazol-5-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-oxazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyrimidin-5-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Fluoropyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Pyrrolidin-1-ylpyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Cyclopropyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N-Methyl-5-[4-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

1′

-({1-[4-(Methylsulfonyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Trifluoromethyl)thio]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chloro-2-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopyridin-1(2H)-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[4-(Methylsulfonyl)-2-oxopiperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

7-Fluoro-1′

-[(1-{4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-[4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]cycloprop anecarboxamide;

N-[4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]benzenesulfonamide;

Methyl allyl[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

1′

-({1-[4-(1H-1 ,2,4-Triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-6-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-4-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-2-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-2-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-({1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

[4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]cyclopropylacetic acid;

6-Chloro-1′

-({1-[4-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[4-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-clpyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Thienyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Naphthyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-4-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Fluoro-4-pyridin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

5-Methoxy-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3-oxo-3H-spiro[2-benzofuran-1,3′

-pyrrolidine]-5-carbonitrile;

1′

-({1 43′

-(Hydroxymethyl)biphenyl-4-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2′

-(Methylthio)biphenyl-4-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2-Naphthyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(Difluoromethoxy)phenyl]cyclopropyl}carbonyl)-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-{[4-(Trifluoromethoxy)benzyl]oxy}phenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(4-Bromophenyl)ethoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyridin-3-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

[4-(4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)-1,3-thiazol-2-yl]acetonitrile;

1′

-({1-[4-(2-Pyridin-3-yl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-3 ,6-dihydropyridine-1(2H)-carboxylate;

4-[(E)-2-(4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)vinyl]benzonitrile;

1′

-{[1-(2-Fluoro-4-pyridin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2H-Indazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3 ,3-Difluoropyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-Isopropyl-2-oxo-1,3-oxazolidin-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxoimidazolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxoimidazolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-Isopropyl-2-oxo-1,3-oxazolidin-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 3-oxo-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{6-[4-(Cyclopropylcarbonyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(Pyridin-4-yloxy)piperidin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Pyridin-4-yloxy)pyrrolidin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Methoxypyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

[4′

-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)biphenyl-3-yl]acetonitrile;

1′

-({1-[4-(6-Aminopyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Hydroxypyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(5-Methylpyridin-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Pyridin-2-yloxy)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Pyridin-3-yloxy)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Pyridin-4-yloxy)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

3-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzonitrile;

1′

-[(1-Biphenyl-3-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1-Naphthyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-6-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(5-Methylisoxazol-3-yl)methoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-3-yl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[5-(Trifluoromethyl)-1,3 ,4-oxadiazol-2-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-tert-Butyl-1,3-thiazol-2-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

,1-[1 ,4-Phenylenebis(cyclopropane-1 , 1-diyl carbonyl)]bis (3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one);

4-Hydroxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-M ethoxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-3-yl cyclobutyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrro li din]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-3H-spiro[2-benzo furan-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(4-Bromophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3 ]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(4-Phenoxyphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-[(1-{4-[(Trifluoromethyl)thio]phenyl}cyclopropyl)carbonyl]spiro[pyrido[3,4-d][1,3 ]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(3-Bromophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3 ]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(3-Methoxyphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3 ]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(6-Chloropyridin-3-yl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(Trifluoromethoxy)phenyl]cyclopropyl}carbonyl)-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Fluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2-Chloro-4-fluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2,4-Difluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(3-Chlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(3,4-Dichlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2,3-Difluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

Ethyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

1′

-[(1-{6-[4-(ethylsulfonyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Phenylpiperazin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(3-Methylbutanoyl)piperazin-1-yl]pyridin-3-yl}cyclopropylcarbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(Cyclopropylmethyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(2,5-Dihydro-1H-pyrrol-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Piperidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Methyl-2-oxopiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Acetyl-2-oxo-piperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

tert-Butyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-({1-[4-(4-Isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Methylsulfonyl)piperazin-1-yl]phenyl}cyclopropylcarbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Methylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Methyl-N-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]cycloprop anecarboxamide;

N-[4-(1-{[3-Oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]acetamide;

1′

-({1-[4-(2-Oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxopiperidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1-Methyl-3-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]imidazolidine-2,4-dione;

1′

-{[1-(4-Morpholin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-3-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Methyl-4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]benzamide;

N,N-Dimethyl-4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]b enz amide;

1′

-[(1-{6-[4-(Methylsulfonyl)phenyl]pyridin-3-yl}cyclopropyl)carb onyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-2-yloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-3-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Isoquinolin-1-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Vinylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-3 ,6-dihydropyridine-1(2H)-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-3 ,6-dihydropyridine-1(2H)-carboxylate;

1′

-({1-[4-(1-Acetyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)-1,2,3,6- tetrahydropyridin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

5-Hydroxy-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-5-ol;

1′

-({1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Pyrrolidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Phenylpiperazin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Ethyl 4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazine-1-carboxylate;

Isopropyl 4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazine-1-carboxylate;

1′

-({1-[6-(4-Chlorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Fluorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Fluoro-2-methylphenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Chloro-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Hydroxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Methoxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(4-Fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-{[4-(Trifluoromethyl)benzyl]oxy}phenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(2-Chloro-4-fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(4-Bromo-2-fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

3-Fluoro-4-[(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)methyl]benzonitrile;

1′

-[(1-{4-[1-(2-Fluorophenyl)ethoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-[1-(4-{1-[(3-Oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)ethyl]benzonitrile;

1′

-({1-[4-(Quinolin-2-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(4-methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Cyclopentyloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Allyloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methoxyethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Cyclopropylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Vinylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-Pyridin-2-ylvinyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Isobutyryl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Acetylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Ethyl 4-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)piperidine-1-carboxylate;

1′

-({1-[4-(1-Isobutyrylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)piperidin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Isopropyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[2-(Dimethylamino)-1,3-thiazol-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

3-Fluoro-4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}benzonitrile;

1′

-({1-[2-Fluoro-4-(4-methyl-1,3-thiazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[5-(Trifluoromethyl)-1,3 ,4-oxadiazol-2-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Methylisoxazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-2-ylethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1 42-Fluoro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Amino-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Benzimidazol-1-yl)-2-fluorophenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4[2-(trifluoro-methyl)-1H-benzimidazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methoxy-1H-benzimidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Ethyl 4-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)piperazine-1-carboxylate;

Isopropyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-({1-[4-(4-Propionylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Methylsulfonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopyridin-1(2H)-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

N-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]methanesulfonamide;

1′

-{[1-(2-Fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Bromophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,3-Difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Chloro-6-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1-Naphthyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Fluorophenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[4-(trifluoro-methyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(2,4-difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[3-(difluoromethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4-methoxy-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4-hydroxy-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(3,4-dichlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chloro-2-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(2,4-difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Chloro-4-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Methylthio)phenyl]cyclopropyl}arbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Trifluoromethyl)thio]phenyl}yclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclo-pentyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

N,N-Dimethyl-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxamide;

Methyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-({1-[2-Fluoro-4-(4-propionylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(4-isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]-2-fluoro-phenyl≡

cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Acetylpiperazin-1-yl)-2-fluorophenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

4-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylpiperazine-1-carboxamide;

1′

-({1-[4-(4-Hydroxypiperidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N,N-Dimethyl-1-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-4-carboxamide;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

1′

-({1-[4-(1-Acetylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Isobutyrylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)piperidin-4-yl]phenyl}cyclopropyl)carb onyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Acetylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Isobutyrylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)piperidin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Isopropyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Methyl 4-hydroxy-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Ethyl 4-hydroxy-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Isopropyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[6-(Pyrrolidin-1-ylcarbonyl)pyridin-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Ethyl-N-methyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N,N-Diethyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

tert-Butyl {4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]phenyl}carbamate;

N,N-Dimethyl-1-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperidine-4-carboxamide;

1′

-{[1-(6-Piperidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Propyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Isobutyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Isopropyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Propyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Isobutyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[4-(Cyclopropylacetyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylacetyl)piperazin-1-yl]-2-fluorophenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(3-Methylbutanoyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Tetrahydro-2H-pyran-4-ylcarbonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Ethyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Propyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

4-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylpiperazine-1-carboxamide;

1′

-({1-[2-Fluoro-4-(4-isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylacetyl)piperazin-1-yl]-2-fluorophenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Ethyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [furo [3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Propyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [furo [3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine- 1-carboxylate;

iso-Propyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [furo [3,4-c]pyridine- 1,3′

-pyrrolidin]-1′

-yl] carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

iso-Butyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [furo [3,4-c]pyridine- 1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine- 1-carboxylate;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazine-1-yl]-2-fluorophenyl}cyclopropyl)carbonyl]-3H-spiro [furo [3,4-c]pyridine- 1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4-[4-(3-methylbutanoyl)piperazin- 1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro [furo [3,4-c]pyridine- 1,3′

-pyrrolidin]-3-one;

N,N-Dimethyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N-Ethyl-5-[4-(1{[3-oxo-1′

H,3H-spiro [2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N-Isopropyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro [2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [2-benzofuran- 1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [2-benzofuran- 1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-ethylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-i-propylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro [2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylpyridine-2-carboxamide;

N-Ethyl-5-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-isopropylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylpyridine-2-carboxamide;

6-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylnicotinamide;

6-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylnicotinamide;

N-Methyl-6[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]nicotinamide;

N,N-Dimethyl-6-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]nicotinamide;

1′

-({1-[4-(1-Isobutyryl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1 43-Fluoro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl 4-(4-{1-[(4,4-dimethyl-2-oxo-1-oxa-7-azaspiro[4.4]non-7-yl)carbonyl]cyclopropyl}-3-fluorophenyl)piperazine-1-carboxylate;

Ethyl 4-(4-{1-[(4,4-dimethyl-2-oxo-1-oxa-7-azaspiro[4.4]non-7-yl)carbonyl]cyclopropyl}-3-fluorophenyl)piperazine-1-carboxylate;

7-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4,4-dimethyl-1-oxa-7-azaspiro[4.4]nonan-2-one;

1′

-{[1-(6-Azetidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(2-Oxoazetidin-1-yl)pyri din-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

Methyl[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

1′

-({1-[4-(2-Oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]phenyl}cyclobutyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

N,N-Diethyl-5-[3-fluoro -4-(1-{[3-oxo-1′

H, 3H- spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-c arbox amide;

1′

-({1-[4-(2- Oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(1H-1 ,2,3-triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1 , 3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2H-1 ,2,3-triazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1 , 3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(1H-1 ,2,4-triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1 , 3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(4H-1 ,2,4-triazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1 , 3′

-pyrrolidin]-3-one;

N-Ethyl-5-[3-fluoro -4-(1-{[3-oxo-1′

H, 3H-spiro[2-benzofuran-1 , 3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide; and

5-[3-Fluoro -4-(1-{[3-oxo -1′

H, 3H-spiro[2-benzofuran-1 , 3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-isopropylpyridine-2-carboxamide;

or a pharmaceutically acceptable salt thereof.

20. A compound of claim 19 selected from:

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-2,3-dihydrospiro[indene-1,4′

-piperidine];

1′

-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-1-methylspiro[indole-3,4′

-piperidin]-2(1H)-one;

tert-Butyl 1′

-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}spiro[indole-3,4′

-piperidine]-1(2H)-carboxylate;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-2,3-dihydro-1H-spiro[isoquinoline-4,4′

-piperidine];

tert-Butyl 1′

-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-1H-spiro[isoquinoline-4,4′

-piperidine]-2(3H)-carboxylate;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,4′

-piperidine];

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[indole-3,4′

-piperidin]-2(1H)-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[1,2-benzisothiazole-3 ,3′

-pyrrolidine]-1,1-dioxide;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-2-yloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-{1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidine];

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-1H-spiro[furo[3,4-c]pyridine-3,3′

-pyrrolidin]-1-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[indole-3,3′

-pyrrolidin]-2(1H)-one;

1′

-({1-[4-(1H-Pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Difluoromethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyrrolidin-1-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyrrolidin-1-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one; and

1′

-{[1-(6-Pyrrolidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one,

or a pharmaceutically acceptable salt thereof.

21. A compound of claim 19 selected from:

1′

-{[1-(6-Pyrrolidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Phenylethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(1-Methylcyclopropyl)methoxy]phenyl}cyclopropyl)-carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(2-Fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-2-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(3-Fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1,3-Benzothiazol-2-ylmethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-{[3,5-Bis(trifluoromethyl)benzyl]oxy}phenyl)-cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[2-(4-Fluorophenyl)ethoxy]phenyl}cyclopropyl)-carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-[(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)methyl]benzonitrile;

1′

-{[1-(4-Phenoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-4-ylmethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-2-ylmethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyridin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Cyclopropylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Fluoro-4-pyridin-2-ylphenyl)cyclopropyl]-carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-(4-Methylphenyl)vinyl]phenyl}-cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-2-ylethoxy)phenyl]cyclopropyl}-carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-2-ylethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-Pyridin-4-ylvinyl]phenyl}cyclopropyl)-carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3,5-Dimethylisoxazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[8′

-(Methylsulfonyl)biphenyl-4-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2H-Indazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Benzimidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methyl-1H-imidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-1,2,4-Triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclopentyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1°

-{[1-(4-Cyclopentylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclopentyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclobutyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Hydroxycyclobutyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Tetrahydro-2H-pyran-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Cyclobutylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Hydroxytetrahydro-2H-pyran-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Hydroxytetrahydro-2H-pyran-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Ethyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1,3-Thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[trans-1-(4-Chlorophenyl)-3-hydroxycyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidine];

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[cis-1-(4-Chlorophenyl)-3-fluorocyclobutyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(1H-Indazol-1-yl)phenyl]cyclobutyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclobutyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Benzimidazol-1-yl)phenyl]cyclobutyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclobutyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-4-ylcyclobutyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyridin-4-ylphenyl)cyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N,N-Dimethyl-4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxamide;

1′

-[(1-{6-[4-(Methylsulfonyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(2-Fluorophenyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3,3-Difluoropyrrolidin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-Hydroxypyrrolidin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-{1-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]pyrrolidin-3-yl}acetamide;

1′

-({1-[6-(1,3-Dihydro-2H-isoindol -2-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3,4-Dihydro-isoquinolin-2(1H)-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Morpholin-4-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Hydroxypiperidin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-{4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]phenyl}acetamide;

1′

-({1-[6-(2-Fluorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Benzothien-3-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,3′

-Bipyridin-5-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-indol -5-yl)pyridine-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethoxy)phenyl]pyridine-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3-Thienyl)pyridine-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethyl)phenyl]pyridine-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-pyrazol-4-yl)pyridine-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Chloropyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(Benzyloxy)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-3-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-pyrazol-4-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(Benzyloxy)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Chloropyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3,4-Dihydroisoquinolin-2(1H)-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1[6-(1,3-Dihydro-2H-isoindol-2-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3,3-Difluoropyrrolidin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Isobutyl 4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazine-1-carboxylate;

2-[4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazin-1-yl]benzonitrile;

1′

-[(1-{6-[4-(4-Fluorophenyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Trifluoromethoxy)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)benzonitrile;

1′

-({1-[6-(3-Chloro-4-fluorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(Methoxymethyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

N-[3-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)phenyl]acetamide; and

4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)benzamide,

or a pharmaceutically acceptable salt thereof.

22. A compound of claim 19 selected from:

1′

-[(1-{6-[4-(Methylsulfonyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Methyl-1H-indol -5-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(1-Benzothien-5-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Quinolin-3-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(3Thienyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-2,3-dihydro-1H-indol -1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl )phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}benzonitrile;

4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}benzenecarbothioamide;

1′

-[(1-{4-[1-(Methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-Pyridin-4-ylvinyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[Cyclopentyl(fluoro)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Tetrahydro-2H-pyran-4-yloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

tert-Butyl (4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)acetate;

(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)acetonitrile;

1′

-[(1-{4-[(5-Methylisoxazol-3-yl)methoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Cyclopentylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-3-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-4-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Quinolin-6-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-3-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-(Trifluoromethyl)-1′

-({1-[4-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Trifluoromethoxy)phenyl]cyclopropyl}carbonyl)-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Difluorophenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Fluoro-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4-fluoro-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

7-Fluoro-1′

-[(1-{4-[(trifluoromethyl)thio]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Bromophenyl)cyclopropyl]carbonyl}-7-fluoro-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-6-chloro-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[4-(trifluoromethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(2-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]cyclopropyl}carbonyl)-3H-spiro [furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzonitrile;

1′

-{[1-(3-(Hydroxymethyl)phenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Bromophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyrrolidin-1-ylcarbonyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzohydrazide;

N-Methyl-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzamide;

4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzenecarbothioamide;

1′

-[(1-{4-[2-(Trifluoromethyl)-1H-imidazol-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Methyl-1H-pyrazol-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Cyclopropyl-4′

-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)biphenyl-4-carboxamide;

1′

-[(1-{4-[5-(Trifluoromethyl)-1H-1 ,2,4-triazol-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-tetrazol-5-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-oxazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Pyrimidin-5-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Fluoropyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Pyrrolidin-1-ylpyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Cyclopropyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N-Methyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

1′

-({1-[4-(Methylsulfonyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Trifluoromethyl)thio]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chloro-2-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopyridin-1(2H)-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[4-(Methylsulfonyl)-2-oxopiperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

7-Fluoro-1′

-[(1-{4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]cyclopropanecarboxamide;

N-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]benzenesulfonamide;

Methyl allyl[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

1′

-({1-[4-(1H-1 ,2,4-Triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-6-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-4-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-2-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-2-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-({1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]cyclopropyl acetic acid;

6-Chloro-1′

-({1-[4-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-clpyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Thienyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Naphthyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-4-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Fluoro-4-pyridin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

5-Methoxy-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3-oxo-3H-spiro[2-benzofuran-1,3′

-pyrrolidine]-5-carbonitrile;

1′

-({1-[3′

-(Hydroxymethyl)biphenyl-4-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2′

-(Methylthio)biphenyl-4-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1,3-Benzothiazol-2-yl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2-Naphthyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(Difluoromethoxy)phenyl]cyclopropyl}carbonyl)-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-{[4-(Trifluoromethoxy)benzyl]oxy}phenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one; and

1′

-[(1-{4-[1-(4-Bromophenyl)ethoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one,

or a pharmaceutically acceptable salt thereof.

23. A compound of claim 19 selected from:

1′

-{[1-(4-Pyridin-3-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

[4-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)-1,3-thiazol-2-yl]acetonitrile;

1′

-({1-[4-(2-Pyridin-3-yl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-3 ,6-dihydropyridine-1(2H)-carboxylate;

4-[(E)-2-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)vinyl]benzonitrile;

1′

-{[1-(2-Fluoro-4-pyridin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2H-Indazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3 ,3-Difluoropyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-Isopropyl-2-oxo-1,3-oxazolidin-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxoimidazolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxoimidazolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-Isopropyl-2-oxo-1,3-oxazolidin-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 3-oxo-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{6-[4-(Cyclopropylcarbonyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(Pyridin-4-yloxy)piperidin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[3-(Pyridin-4-yloxy)pyrrolidin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(6-Methoxypyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

[4′

-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)biphenyl-3-yl]acetonitrile;

1′

-({1-[4-(6-Aminopyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4- -(6-Hydroxypyridin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(5-Methylpyridin-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Pyridin-2-yloxy)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Pyridin-3-yloxy)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Pyridin-4-yloxy)methyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

3-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)benzonitrile;

1′

-[(1-Biphenyl-3-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1-Naphthyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-6-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(5-Methylisoxazol-3-yl)methoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-3-yl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[5-(Trifluoromethyl)-1,3,4-oxadiazol-2-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-tert-Butyl-1,3-thiazol-2-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

, 1″

-[1 ,4-Phenylenebis(cyclopropane-1,1-diylcarbonyl)]bis(3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one);

4-Hydroxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Methoxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-3-ylcyclobutyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclobutyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(4-Bromophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(4-Phenoxyphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-[(1-{4-[(Trifluoromethyl)thio]phenyl}cyclopropyl)carbonyl]spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(3-Bromophenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(3-Methoxyphenyl)cyclopropyl]carbonyl}spiro[pyrido[3,4-d][1,3]oxazine-4,3′

-pyrrolidin]-2(1H)-one;

1′

-{[1-(6-Chloropyridin-3-yl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one; and

1′

-({1-[4-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one,

or a pharmaceutically acceptable salt thereof.

24. A compound of claim 19 selected from:

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-({1-[4-(Trifluoromethoxy)phenyl]cyclopropyl}carbonyl)-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(4-Fluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2-Chloro-4-fluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2,4-Difluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(3-Chlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

l′

-{[1-(3,4-Dichlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2,3-Difluorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}-7H-spiro[furo[3,4-b]pyridine-5,3′

-pyrrolidin]-7-one;

Ethyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

1′

-[(1-{6-[4-(ethylsulfonyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Phenylpiperazin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(3-Methylbutanoyl)piperazin-1-yl]pyridin-3-yl}cyclopropylcarbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{6-[4-(Cyclopropylmethyl)piperazin-1-yl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(2,5-Dihydro-1H-pyrrol-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Piperidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Methyl-2-oxopiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Acetyl-2-oxo-piperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

tert-Butyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-({1-[4-(4-Isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Methylsulfonyl)piperazin-1-yl]phenyl}cyclopropylcarbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Methylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Methyl-N-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]cyclopropanecarboxamide;

N-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]acetamide;

1′

-({1-[4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopiperidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1-Methyl-3-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]imidazolidine-2,4-dione;

1′

-{[1-(4-Morpholin-4-ylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Pyridin-3-ylcyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Methyl-4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]benzamide;

N,N-Dimethyl-4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]benzamide;

1′

-[(1-{6-[4-(Methylsulfonyl)phenyl]pyridin-3-yl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-2-yloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Pyridin-3-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Isoquinolin-1-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Vinylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-3 ,6-dihydropyridine-1(2H)-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-3 ,6-dihydropyridine-1(2H)-carboxylate;

1′

-({1-[4-(1-Acetyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)-1,2,3,6-tetrahydropyridin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

5-Hydroxy-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-5-ol;

1′

-({1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(6-Pyrrolidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Phenylpiperazin-1-yl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Ethyl 4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazine-1-carboxylate;

Isopropyl 4-(5-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}pyridin-2-yl)piperazine-1-carboxylate;

1′

-({1-[6-(4-Chlorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Fluorophenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(4-Fluoro-2-methylphenyl)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-Quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Chloro-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Hydroxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-Methoxy-1′

-[(1-quinolin-4-ylcyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(4-Fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-{[4-(Trifluoromethyl)benzyl]oxy}phenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(2-Chloro-4-fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(4-Bromo-2-fluorobenzyl)oxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

3-Fluoro-4-[(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)methyl]benzonitrile;

1′

-[(1-{4-[1-(2-Fluorophenyl)ethoxy]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

4-[1-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenoxy)ethyl]benzonitrile;

1′

-({1-[4-(Quinolin-2-ylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(4-methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methoxyphenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Cyclopentyloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Allyloxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Methoxyethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Cyclopropylmethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Vinylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(E)-2-Pyridin-2-ylvinyl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Isobutyryl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Acetylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Ethyl 4-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)piperidine-1-carboxylate;

1′

-({1-[4-(1-Isobutyrylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)piperidin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Isopropyl-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[2-(Dimethylamino)-1,3-thiazol-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

3-Fluoro-4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}benzonitrile;

1′

-({1-[2-Fluoro-4-(4-methyl-1,3-thiazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one; and

1′

-[(1-{4-[5-(Trifluoromethyl)-1,3 ,4-oxadiazol-2-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one,

or a pharmaceutically acceptable salt thereof.

25. A compound of claim 19 selected from:

1′

-({1-[4-(3-Methylisoxazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-Pyridin-2-ylethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({142-Fluoro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(3-Amino-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1H-Benzimidazol-1-yl)-2-fluorophenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4[2-(trifluoro-methyl)-1H-benzimidazol-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

l′

-({1-[4-(2-Methoxy-1H-benzimidazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Ethyl 4-(4-{1-[(3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl)carbonyl]cyclopropyl}phenyl)piperazine-1-carboxylate;

Isopropyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-({1-[4-(4-Propionylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyri dine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Methylsulfonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxopyridin-1(2H)-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

N-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]methanesulfonamide;

1′

-{[1-(2-Fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Chlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Bromophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-(Trifluoromethyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Methoxyphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,3-Difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Chloro-6-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(1-Naphthyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Fluorophenyl)cyclopropyl]carbonyl}-6-(trifluoromethyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(4-methylphenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[4-(trifluoro-methyl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(2,4-difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-({1-[3-(difluoromethoxy)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4-methoxy-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4-hydroxy-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(3,4-dichlorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chloro-2-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

6-Chloro-1′

-{[1-(2,4-difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2-Chloro-4-fluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(2,4-Difluorophenyl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(Methylthio)phenyl]cyclopropyl}arbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[(Trifluoromethyl)thio]phenyl}yclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-{[1-(4-Chlorophenyl)cyclo-pentyl]carbonyl}-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

N,N-Dimethyl-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxamide;

Methyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-({1-[2-Fluoro-4-(4-propionylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(4-isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]-2-fluoro-phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(4-Acetylpiperazin-1-yl)-2-fluorophenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

4-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylpiperazine-1-carboxamide;

1′

-({1-[4-(4-Hydroxypiperidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N,N-Dimethyl-1-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-4-carboxamide;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

1′

-({1-[4-(1-Acetylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Isobutyrylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)piperidin-4-yl]phenyl}cyclopropyl)carb onyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Acetylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Isobutyrylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionylpiperidin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[1-(3-Methylbutanoyl)piperidin-4-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Isopropyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Methyl 4-hydroxy-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Ethyl 4-hydroxy-4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperidine-1-carboxylate;

Isopropyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[6-(Pyrrolidin-1-ylcarbonyl)pyridin-3-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Ethyl-N-methyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N,N-Diethyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

tert-Butyl {4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]phenyl}carbamate;

N,N-Dimethyl-1-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperidine-4-carboxamide; and

1′

-{[1-(6-Piperidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one, or pharmaceutically acceptable salt thereof.

26. A compound of claim 19 selected from:

1′

-({1-[2-Fluoro-4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(2-oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

l′

-({1-[2-Fluoro-4-(2-oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

l′

-({1-[4-(2-oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2-oxoazetidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Propyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Isobutyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Isopropyl 4-[5-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)pyridin-2-yl]piperazine-1-carboxylate;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Propyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Isobutyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[4-(Cyclopropylacetyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylacetyl)piperazin-1-yl]-2-fluorophenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(3-Methylbutanoyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Tetrahydro-2H-pyran-4-ylcarbonyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Ethyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Propyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

4-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylpiperazine-1-carboxamide;

1′

-({1-[2-Fluoro-4-(4-isobutyrylpiperazin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylacetyl)piperazin-1-yl]-2-fluorophenyl}cyclopropyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Ethyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

Propyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

iso-Propyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

iso-Butyl 4-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazine-1-yl]-2-fluorophenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{2-Fluoro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}cyclopropyl)carbonyl]-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

N,N-Dimethyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N-Ethyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

N-Isopropyl-5-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-ethylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-i-propylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylpyridine-2-carboxamide;

N-Ethyl-5-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-c arbox amide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-isopropylpyridine-2-carboxamide;

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylpyridine-2-carboxamide;

6-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-methylnicotinamide;

6-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N,N-dimethylnicotinamide;

N-Methyl-6-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]nicotinamide;

N,N-Dimethyl-6-[4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]nicotinamide;

1′

-({1-[4-(1-Isobutyryl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[4-(1-Propionyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1 43-Fluoro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

Methyl 4-(4-{1-[(4,4-dimethyl-2-oxo-1-oxa-7-azaspiro[4.4]non-7-yl)carbonyl]cyclopropyl}-3-fluorophenyl)piperazine-1-carboxylate;

Ethyl 4-(4-{1-[(4,4-dimethyl-2-oxo-1-oxa-7-azaspiro[4.4]non-7-yl)carbonyl]cyclopropyl}-3-fluorophenyl)piperazine-1-carboxylate;

7-{[1-(4-Chlorophenyl)cyclopropyl]carbonyl}-4,4-dimethyl-1-oxa-7-azaspiro[4.4]nonan-2-one;

1′

-{[1-(6-Azetidin-1-ylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-({1-[6-(2-oxoazetidin-1-yl)pyri din-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Methyl[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

Methyl[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]carbamate;

1′

-({1-[4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-3-one;

1′

-[(1-{4-[4-(Cyclopropylcarbonyl)piperazin-1-yl]phenyl}cyclobutyl)carbonyl]-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

Ethyl 4-[4-(1-{[3-oxo-1′

H,3H-spiro[furo[3,4-c]pyridine-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]piperazine-1-carboxylate;

N,N-Diethyl-5-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide;

1′

-({1-[4-(2-oxopyrrolidin-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(1H-1 ,2,3-triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(2H-1 ,2,3-triazol-2-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(1H-1 ,2,4-triazol-1-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

1′

-({1-[2-Fluoro-4-(4H-1 ,2,4-triazol-4-yl)phenyl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-3-one;

N-Ethyl-5-[3-fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide; and

5-[3-Fluoro-4-(1-{[3-oxo-1′

H,3H-spiro[2-benzofuran-1,3′

-pyrrolidin]-1′

-yl]carbonyl}cyclopropyl)phenyl]-N-isopropylpyridine-2-carboxamide;

or a pharmaceutically acceptable salt thereof.