5′ modified nucleosides and oligomeric compounds prepared therefrom
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Abstract
The present invention provides 5′ modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5′-substituent and an optional 2′ substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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Citations
20 Claims
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1. A 5′
- modified nucleoside having Formula Ic;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- modified nucleoside having Formula Ic;
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18. An oligomeric compound comprising a 5′
- modified nucleoside having Formula IIb;
- View Dependent Claims (19, 20)
- modified nucleoside having Formula IIb;
Specification