Heparin coatings
First Claim
1. A method of preparing a medical device coating comprising exposing the medical device to a solution comprising a first polymer and a polymeric heat-initiated crosslinker to form a layer on the surface and heating the layer to thereby covalently crosslink the first polymer with the heat-initiated polymeric cross-linker and form the coating on the medical device, wherein the first polymer comprises a copolymer of a heparin macromer, wherein the heparin macromer is selected from the group consisting of a heparin methacrylate, a heparin quaternary ammonium salt complex methacrylate, a heparin methacrylate salt, and a heparin polyethylene glycol methacrylate.
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Abstract
The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.
53 Citations
10 Claims
- 1. A method of preparing a medical device coating comprising exposing the medical device to a solution comprising a first polymer and a polymeric heat-initiated crosslinker to form a layer on the surface and heating the layer to thereby covalently crosslink the first polymer with the heat-initiated polymeric cross-linker and form the coating on the medical device, wherein the first polymer comprises a copolymer of a heparin macromer, wherein the heparin macromer is selected from the group consisting of a heparin methacrylate, a heparin quaternary ammonium salt complex methacrylate, a heparin methacrylate salt, and a heparin polyethylene glycol methacrylate.
Specification