Microbicidal compositions and methods of production use thereof

• US 9,131,686 B2
• Filed: 05/24/2012
• Issued: 09/15/2015
• Est. Priority Date: 05/25/2011
• Status: Active Grant

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Inventors: Uretsky, Laura S., Horan, Kevin
• Primary Examiner(s): Peselev, Elli
• Application Number:
  US14/119,649
• Publication Number:
  US 20140094424A1
• Time in Patent Office: 1,209 Days
• US Class Current: 1/1
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/7036 having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins

Abstract

Microbicidal compositions that exhibit enhanced microbial efficacy are disclosed, as well as methods of producing and using the microbicidal compositions.

Claims

1. A system, comprising:

a microbicidal composition for inhibiting growth of microbes comprising gentamicin and at least one propionate;

at least one biosensor; and

a means for applying said microbicidal composition to at least a portion of said biosensor and wherein the microbicidal composition does not substantially affect a biological activity of the at least one biosensor.

2. The system of claim 1, wherein the at least one propionate of the microbicidal composition is selected from the group consisting of calcium propionate, sodium propionate and combinations thereof.

3. The system of claim 2, wherein the propionate is calcium propionate, and the concentration of calcium propionate is in a range of from about 0.25 mmol/L to about 2.5 mmol/L.

4. The system of claim 2, wherein the propionate is sodium propionate, and the concentration of sodium propionate is in a range of from about 4 mmol/L to about 40 mmol/L.

5. The system of claim 1, wherein the concentration of gentamicin is in a range of from about 0.1% to about 1%.

6. The system of claim 1, wherein said microbicidal composition has a pH in a range of from about 6.0 to about 8.0.

7. The system of claim 1, wherein the at least one biosensor comprises creatinine.

8. The system of claim 1, wherein the at least one biosensor comprises blood urea nitrogen (BUN).