Method and apparatus for detecting abnormal living tissue

• US 9,131,847 B2
• Filed: 06/04/2008
• Issued: 09/15/2015
• Est. Priority Date: 11/08/2007
• Status: Active Grant

• Current Assignee: Olympus Corporation
• Original Assignee: Olympus Corporation
• Inventors: Gono, Kazuhiro, Suga, Takeshi
• Primary Examiner(s): Brutus, Joel F
• Application Number:
  US12/132,932
• Publication Number:
  US 20090306522A1
• Time in Patent Office: 2,659 Days
• Field of Search: 600/473, 600/476, 600/478, 600/106, 600/160, 600/178, 600/310, 600/325, 600/327, 600/332, 600/339, 356/316, 356/364, 356/369, 356/479
• US Class Current: 1/1
• CPC Class Codes: A61B 1/00087 Tools A61B17/00234 takes precedence
• CPC Class Codes: A61B 1/00135 Oversleeves mounted on the endoscope prior to insertion
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence

Abstract

Light scattering and absorption techniques for the detection of possible abnormal living tissue. Apparatus and methods for utilizing multiple blood content detection sensors and/or contact sensors for beneficially providing data to better guide an endoscope or colonoscope to locate abnormal tissue, tumors, or tissues that precede the development of such lesions or tumors.

Claims

1. An apparatus that comprises:

a cylindrically-shaped probe that has a circumference, wherein said cylindrically-shaped probe comprises;

a plurality of measurement units outwardly disposed circumferentially along and in a raised helical portion of an outer surface of said cylindrically-shaped probe, said plurality of measurement units thereby arrayed in a substantially helical arrangement, wherein said raised helical portion is sufficiently large to contact a tissue that forms an intended cavity of a living body;

wherein each of the plurality of measurement units includes one of a plurality of illuminators and one of plurality of collectors, and

a processing unit coupled to the plurality of measurement units, wherein

each of the plurality of illuminators of the plurality of measurement units is configured to illuminate a different tissue region within a living body,

each of the plurality of collectors is configured to collect interacted light detected by a corresponding one of the plurality of measurement units from one of the different tissue regions illuminated by a corresponding one of the plurality of illuminators, and to transmit the collected interacted light to the processing unit, a blood content estimator of the processing unit configured to generate a signal indicative of blood content measurement, and

an indicator is coupled to the processing unit to indicate a parameter based on signals from the plurality of measurement units and configured to guide said cylindrically-shaped probe through a cavity of the living body to locate abnormal tissue.

2. The apparatus of claim 1 wherein the processing unit further comprises:

a comparator that compares signals indicative of light interacted with a tissue region for the plurality of measurement units, and that generates at least one comparison signal, wherein

the blood content estimator is configured to calculate information indicative of the blood content in an illuminated tissue based on the at least one comparison signal.

3. The apparatus of claim 1 wherein each of the plurality of illuminators emits collimated light.

4. The apparatus of claim 3 wherein each of the plurality of illuminators emits polarized light.

5. The apparatus of claim 1 that further comprises at least one polarizer proximate to a corresponding one of the plurality of collectors.

6. The apparatus of claim 5 wherein at least one of the plurality of measurement units includes two polarizers located proximate to a corresponding one of the plurality of collectors and wherein the two polarizers have substantial orthogonal polarizations to one another.

7. The apparatus of claim 1 that further comprises an endoscope.

8. The apparatus of claim 7, wherein the plurality of measurement units are positioned proximate a distal tip of the endoscope.

9. The apparatus of claim 1 wherein each of the plurality of illuminators comprises one of a plurality of first optical fibers through which light from a light source passes to illuminate one of the different tissue regions, and each of the plurality of collectors comprises one of a plurality of second optical fibers to receive interacted light from one of the different tissue regions.

10. The apparatus of claim 9 wherein each of the plurality of measurement units includes an optical system to direct the light from a corresponding one of the plurality of first optical fibers and to direct light to a corresponding one of the plurality of second optical fibers.

11. The apparatus of claim 1 wherein the processing unit comprises a comparator that compares the signals generated substantially simultaneously by the plurality of measurement units, and that generates at least one corresponding comparison signal, said processing unit further including a blood content estimator configured to calculate information indicative of the blood content in an illuminated tissue based on the comparison signal.

12. An apparatus configured to determine a characteristic of a living tissue that forms a cavity of a living body, wherein the apparatus comprises:

a cylindrically-shaped probe configured to be inserted into a cavity of a living body, including;

an outer surface of said cylindrically-shaped probe that has a plurality of measurement units outwardly disposed thereon, the plurality of measurement units disposed circumferentially along and in a raised helical portion of said outer surface of said cylindrically-shaped probe, said plurality of measurement units thereby arrayed in a substantially helical arrangement, wherein said raised helical portion is sufficiently large to contact a tissue that forms an intended cavity of a living body and facilitate contact between said plurality of measurement units and said tissue, wherein each of the plurality of measurement units includes one of a plurality of illuminators and one of a plurality of collectors, and

a processor coupled to the plurality of measurement units, wherein

each of the plurality of illuminators is configured to illuminate a different portion of tissue within the living body,

each of the plurality of collectors is adapted to collect interacted light detected by a corresponding one of the plurality of measurement units from one of the different portions of tissue illuminated by a corresponding one of the plurality of illuminators and to transmit the collected interacted light to the processor, and

the processor includes a blood content estimator configured to provide an indication of blood content within illuminated tissue to guide said cylindrically-shaped probe.

13. The apparatus of claim 12 wherein each of the plurality of illuminators comprises one of a plurality of first optical fibers through which light from a light source passes to illuminate one of the different tissue regions, and each of the plurality of collectors comprises one of a plurality of second optical fibers to receive interacted light from one of the different tissue regions.

14. The apparatus of claim 13 wherein each of the plurality of measurement units includes an optical system to direct the light from a corresponding one of the plurality of first optical fibers and to direct light to a corresponding one of the plurality of second optical fibers.

15. An apparatus for use within a cavity of a living body, wherein the apparatus comprises:

an endoscope;

a sheath to receive the endoscope, wherein said sheath has an inner surface and an outer surface with a raised helical portion;

a plurality of measurement units outwardly disposed circumferentially along and in said raised helical portion on the outer surface of the sheath, said plurality of measurement units thereby arrayed in a substantially helical arrangement, wherein each of the plurality of measurement units includes one of a plurality of illuminators and one of a plurality of collectors, and

a processing unit coupled to the plurality of measurement units, wherein

each of the plurality of illuminators of the plurality of measurement units is configured to illuminate a different region of tissue within the living body,

each of the plurality of collectors is configured to collect interacted light from a corresponding one of the plurality of measurement units that detected the interacted light from one of the different tissue regions illuminated by a corresponding one of the plurality of illuminators, said collector being configured to transmit the collected interacted light to the processing unit;

the processing unit includes a blood content estimator that is configured to determine blood content within illuminated tissue regions based on the signals transmitted by the plurality of collectors; and

an indicator coupled to the processing unit is configured to indicate a parameter based on the determined blood content to guide the endoscope through the cavity of the living body to locate abnormal tissue.

16. The apparatus of claim 15 wherein an outer circumference of the sheath is larger than the cavity of a living tissue.

17. The apparatus of claim 15, wherein the apparatus further comprises a sensor to detect contact between the sheath and tissue that forms the cavity of the living body.

18. The apparatus of claim 17 wherein at least one of the plurality of measurement units are energized in accordance with a received signal from the sensor.

19. The apparatus of claim 15 wherein each of the plurality of illuminators comprises one of a plurality of first optical fibers through which light from a light source passes to illuminate one of the different tissue regions, and each of the plurality of collectors comprises one of a plurality of second optical fibers to interacted light from one of the different tissue regions.

20. The apparatus of claim 19 wherein each of the plurality of measurement units includes an optical system to direct the light from a corresponding one of the plurality of first optical fibers and to direct light to a corresponding one of the plurality of second optical fibers.

21. A method for guiding an endoscope within a cavity of a living organism, wherein the method comprises the steps of:

providing said endoscope with a plurality of measurement units disposed circumferentially along and in a raised helical portion on an outer surface of the endoscope, said plurality of measurement units thereby arrayed in a substantially helical arrangement, wherein each of the plurality of measurement units includes one of a plurality of illuminators and one of a plurality of collectors;

inserting the endoscope into the cavity of the living organism,

contacting the endoscope with a surface of tissue that forms the cavity;

illuminating different portions of a contacted tissue surface through said plurality of illuminators;

detecting interacted light from an illuminated tissue surface through one of said plurality of measurement units;

collecting said detected interacted light by the one collector of the one measurement unit;

transmitting the collected light by the one collector to a processing unit;

processing said received interacted light by a blood content estimator of the processing unit to determine a parameter indicative of blood content of the illuminated tissue; and

guiding the endoscope through said cavity based on said parameter to locate abnormal tissue.

22. The method of claim 21 wherein said helical portion is provided on an outer circumference of an inflatable cuff surrounding said endoscope and the contacting step is achieved by inflating said inflatable cuff.

23. The method of claim 21, wherein the method further comprises the steps of repositioning the endoscope within the living body based on a determined parameter.