Pulsed lighting imaging systems and methods

• US 9,131,861 B2
• Filed: 11/28/2005
• Issued: 09/15/2015
• Est. Priority Date: 11/30/2004
• Status: Active Grant

• Current Assignee: Academisch Medisch Centrum
• Original Assignee: Academisch Medisch Centrum
• Inventors: Ince, Can, Sholten, Theodorus Antonius Herman Maria
• Primary Examiner(s): FERNANDEZ, KATHERINE L
• Application Number:
  US11/288,844
• Publication Number:
  US 20060184037A1
• Time in Patent Office: 3,578 Days
• Field of Search: 600/310, 600/316, 600/322, 600/365, 600/473, 600/476, 600/323, 356/364, 356/367, 356/369, 356/477, 356/479
• US Class Current: 1/1
• CPC Class Codes: A61B 1/00186 with imaging filters
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 1/06 with illuminating arrangements
• CPC Class Codes: A61B 1/0607 for annular illumination
• CPC Class Codes: A61B 1/0638 providing two or more wavelengths
• CPC Class Codes: A61B 1/0646 with illumination filters
• CPC Class Codes: A61B 1/0684 using light emitting diodes [LED]
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: G02B 21/084 having annular illumination around the objective
• CPC Class Codes: G02B 21/365 Control or image processing arrangements for digital or video microscopes G02B21/361, G02B21/362 take precedence

Abstract

Systems and methods for monitoring patients utilizing reflectance avoidance as well as other imaging modalities. Information regarding perfusion, oxygen saturation and oxygen availability, as well as others may be obtained. System embodiments may include a light source, a light transport body configured to project light from the light source to an examination substrate and transmit light reflected by the examination substrate, and an analysis section in optical communication with the light transport body. The light source may be pulsed in order to improve the quality of video images produced by the systems.

Claims

1. An imaging system for analyzing a tissue substrate, comprising;

a light source;

a light transport body configured to project light from the light source to the tissue substrate and transmit light from the tissue substrate;

an analysis section which is in optical communication with the light transport body and which includes a video imaging system that utilizes a plurality of sets of field lines integrated over staggered time intervals that overlap in an overlap period for odd and even field lines that will be integrated into a single image; and

a controller which is in communication with the light source and video imaging system and which is configured to activate the light source to emit a synchronized light pulse having a duty cycle of lighting of about 50% to be on only during the overlap period of odd and even field lines that will be integrated into a single image of the video imaging system.

2. The system of claim 1 wherein the analysis section further comprises a reflectance avoidance imaging module, a reflectance spectrophotometry module, an fluorescence imaging module and a beam director which is in optical communication with the light transport body and which is configured to direct at least a portion of the light from the tissue substrate to at least one of the reflectance avoidance imaging module, the reflectance spectrophotometry module, and the fluorescence imaging module.

3. The system of claim 2 wherein the beam director is configured to be selectively actuated by a user.

4. The system of claim 2 wherein the beam director comprises at least one device selected from the group consisting of a beam splitter, dichroic junction, prism, and mirror.

5. The system of claim 1 wherein the light transport body further comprises one or more illumination passages configured to project light from the light source and an imaging passage configured to transmit the light from the tissue substrate, wherein the imaging passage is optically isolated from the one or more illumination passages.

6. The system of claim 1 wherein the light source is selected from the group consisting of incandescent lamps, gas discharge lamps, light emitting diodes, laser diodes, gas lasers, excimer lasers, solid state lasers, chemical lasers, dye lasers, infrared sources, and UV sources.

7. The system of claim 1 further comprising a lens positioned within an imaging passage and wherein the imaging passage is in optical communication with the video imaging system.

8. The system of claim 7 further comprising one or more optical modulators positioned within the imaging passage.

9. The system of claim 1 wherein the duty cycle of lighting of about 50% comprises an interval of 1/60 of a second.

10. An imaging system for analyzing a tissue substrate, comprising;

an LED light source;

a light transport body configured to project light from the LED light source to the tissue substrate from a side and transmit light from the tissue substrate;

an analysis section which is in optical communication with the light transport body, which is configured to receive light from the tissue substrate and which includes a reflectance avoidance imaging module, a reflectance spectrophotometry module, a fluorescence imaging module and a video imaging system that utilizes a plurality of sets of field lines integrated over staggered time intervals that overlap in an overlap period for odd and even field lines that will be integrated into a single image; and

a controller which is in communication with the LED light source and video imaging system and which is configured to synchronously pulse the LED light source so as to have a duty cycle of lighting of about 50% and to be on only during the overlap period of odd and even field lines that will be integrated into a single image of the video imaging system.

11. The system of claim 10 further comprising a beam director in optical communication with the light transport body configured to direct at least a portion of the received light to at least one of the reflectance avoidance imaging module, the reflectance spectrophotometry module, and the fluorescence imaging module.

12. The system of claim 10 wherein the light transport body further comprises one or more illumination passages which are positioned radially around an imaging passage.

13. The system of claim 12 wherein the one or more illumination passages comprise one or more optical fibers configured to deliver illuminating energy from a remote location.

14. The system of claim 10 wherein the light transport body has a proximal end and a distal end and wherein the LED light source comprises one or more LED'"'"'s positioned at the distal end of the light transport body.

15. The system of claim 10 further comprising an optically transparent disposable cap device configured to be detachably coupled to a distal end of the light transport body.

16. The system of claim 10 wherein the LED light source comprises LED'"'"'s emitting a single light wavelength.

17. The system of claim 10 wherein the light transport body has a proximal end, a distal end and an engaging device disposed at the distal end of the light transport body.

18. The system of claim 17 wherein the engaging device comprises an inflatable device configured to dissipate a pressure applied to the tissue substrate.

19. The system of claim 10 wherein the duty cycle of lighting of about 50% comprises an interval of 1/60 of a second.

20. A method of monitoring a patient, comprising:

providing an imaging system including a light source, a light transport body configured to project light from the light source to tissue substrate and transmit light from the tissue substrate, an analysis section in optical communication with the light transport body and a video imaging system that utilizes a plurality of sets of field lines integrated over staggered time intervals that overlap in an overlap period for odd and even field lines that will be integrated into a single image and a controller configured to activate the light source so as to have a duty cycle of lighting of about 50% and only within the overlap period of odd and even field lines that will be integrated into a single image of the video imaging system;

illuminating a tissue substrate of the patient over a duty cycle of lighting of about 50% with pulsed synchronized light from the light source only during an overlap period of odd and even field lines that will be integrated into a single image of the video imaging system;

receiving light from below a surface of the tissue substrate; and

generating an image of the tissue substrate with the sets of field lines integrated during the overlap period.

21. The method of claim 20 wherein the tissue substrate comprises vascularized tissue and further comprising imaging microcirculation of the tissue and obtaining microcirculatory information.

22. The method of claim 21 further comprising:

obtaining oxygen availability information, and adequacy of oxygenation of tissue cells information;

making an early and sensitive determination regarding at least one state of shock in the patient; and

using the information obtained to guide resuscitation therapies aimed at correcting a state of shock in the patient.

23. The method of claim 22 wherein obtaining adequacy of oxygenation of tissue cells information comprises measuring tissue CO₂ or NADH via fluorescence imaging.

24. The method of claim 22 wherein making an early and sensitive determination regarding at least one state of shock comprises making an early and sensitive determination regarding a state of shock selected from septic shock, hypovolemic shock, cardiogenic shock and obstructive septic shock, in the patient.

25. The method of claim 21 further comprising:

obtaining oxygen availability information and an adequacy of oxygenation of tissue cells information; and

making an early and sensitive determination regarding cardiovascular disease and cardiovascular failure of the patient.

26. The method of claim 20 further comprising illuminating the tissue substrate without influencing microcirculation of the tissue substrate.

27. The method of claim 20 further comprising reflectance filtering of the light received from below a surface of the tissue substrate that includes OPS imaging or Mainstream Dark Field imaging.

28. The method of claim 20 further comprising reflectance filtering of the light received from below a surface of the tissue substrate that includes Mainstream Dark Field imaging.

29. The method of claim 20 wherein illuminating the tissue substrate comprises sidestream dark field imaging wherein incident and light received from below a surface of the tissue substrate do not travel down a same pathway.

30. The method of claim 20 wherein illuminating a tissue substrate of the patient over a duty cycle of lighting of about 50% comprises illuminating a tissue substrate of the patient over an interval of 1/60 of a second.