Noninvasive measurements in a human body

• US 9,131,880 B2
• Filed: 03/25/2013
• Issued: 09/15/2015
• Est. Priority Date: 03/16/2005
• Status: Active Grant

• Current Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Original Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Inventors: Balberg, Michal, Pery-Shechter, Revital
• Primary Examiner(s): Brutus, Joel F
• Application Number:
  US13/849,943
• Publication Number:
  US 20130317326A1
• Time in Patent Office: 904 Days
• Field of Search: 600/407, 600/478, 600/476
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/4227 characterised by straps, belts, cuffs or braces
• CPC Class Codes: A61B 8/4494 characterised by the arrangement of the transducer elements devices for short-range imaging using particular transducer elements arrangements under G01S15/8909; arrangements of transducers in generation of mechanical vibrations of infrasonic, sonic or ultrasonic frequency B06B1/0607
• CPC Class Codes: G01S 15/8968 using acoustical modulation of a light beam acousto-optical light control devices G02F1/11, G02F1/33

Abstract

Apparatus and methods are provided including directing acoustic radiation toward a region of interest within a subject'"'"'s body. Light is transmitted from a light emitter to a light detector such that a first light portion is transmitted without passing through the subject'"'"'s tissue, and a second light portion is transmitted via the region of interest. Scattered light of the second light portion contains a tagged component corresponding to photons tagged by the acoustic radiation, and an untagged component corresponding to photons untagged by the acoustic radiation. Light of the first light portion undergoes an interaction with light of the second light portion at the light detector. A property of tissue of the region of interest is determined, by decoupling from each other the tagged and untagged components of the second light portion, based upon the interaction between the light of the first and second light portions.

Claims

1. Apparatus comprising a measurement system adapted to perform non-invasive measurements on a subject'"'"'s body, the measurement system comprising:

a measurement unit comprising;

an acoustic unit configured to direct acoustic radiation toward a region of interest within the subject'"'"'s body; and

an optical unit comprising;

an illumination assembly that comprises at least one light emitter, and at least one first light guiding unit and at least one second light guiding unit,

the at least one light emitter, the at least one first light guiding unit and the at least one second light guiding unit being optically coupled to each other via a first optical coupler; and

a light detection assembly that comprises at least one light detector, the at least one second light guiding unit, and at least one third light guiding unit,

the at least one light detector, the at least one second light guiding unit, and the at least one third light guiding unit being optically coupled to each other via a second optical coupler,

the measurement unit being configured to provide a first operating condition such that;

the acoustic unit directs acoustic radiation toward a region of interest within the subject'"'"'s body,

a first light portion is transmitted from the at least one light emitter to the at least one light detector, by being transmitted along the at least one second light guiding unit, from the first optical coupler to the second optical coupler, without passing through tissue of the subject'"'"'s body, and

a second light portion is transmitted from the at least one light emitter to the at least one light detector, by being transmitted from the at least one first light guiding unit to the at least one third light guiding unit via the region of interest within the subject'"'"'s body, such that scattered light of the second light portion that passes into the at least one third light guiding unit contains a tagged component corresponding to photons tagged by the acoustic radiation, and an untagged component corresponding to photons untagged by the acoustic radiation, and

a control unit configured to decouple, from each other, the tagged component and the untagged component of the second light portion received at the at least one light detector, based upon an interaction between light of the first light portion and light of the second light portion received at the at least one light detector.

2. The apparatus according to claim 1, wherein the at least one first light guiding unit, the at least one second light guiding unit, and the at least one third light guiding unit comprise, respectively, first, second and third optical fibers.

3. The apparatus according to claim 1, wherein the at least one first light guiding unit, the at least one second light guiding unit, and the at least one third light guiding unit comprise, respectively, first, second, and third optical fiber bundles.

4. The apparatus according to claim 1, wherein the measurement unit is configured to provide the first operating condition, by providing an operating condition such that light of the first light portion is coherent with light of the second light portion.

5. The apparatus according to claim 1, wherein:

the measurement unit is configured to further provide a second operating condition such that the second optical coupler blocks the second light portion from arriving at the at least one light detector by blocking light that is transmitted via the at least one third light guiding unit, and

the control unit is configured to determine a parameter of light emitted by the at least one light emitter, by analyzing light of the first light portion that was received at the at least one light detector, while the measurement unit provided the second operating condition.

6. The apparatus according to claim 1, wherein:

the measurement unit is configured to further provide a second operating condition such that;

the acoustic unit does not direct acoustic radiation toward the region of interest within the subject'"'"'s body,

the first light portion is transmitted from the at least one light emitter to the at least one light detector by being transmitted along the at least one second light guiding unit from the first optical coupler to the second optical coupler without passing through tissue of the subject'"'"'s body, and

the second light portion is transmitted from the at least one light emitter to the at least one light detector by being transmitted from the at least one first light guiding unit to the at least one third light guiding unit via the region of interest within the subject'"'"'s body, such that scattered light of the second light portion that passes into the at least one third light guiding unit contains photons untagged by the acoustic radiation, and does not contain photons that were tagged by the acoustic radiation, and

the control unit is configured to determine a property of the tissue of the region of interest, based upon comparing light received at the at least one light detector while the measurement unit operates at the first operating condition to light received at the detector while the measurement unit operates at the second operating condition.

7. The apparatus according to claim 1, wherein:

the measurement unit is configured to provide a second operating condition such that the second optical coupler is configured to block the first light portion from arriving at the at least one light detector by blocking light that is transmitted via the at least one second light guiding unit, and

the control unit is configured to;

analyze light that was received at the at least one light detector, while the light of the first light portion was blocked from arriving at the at least one light detector, and

in response thereto, decouple a contribution of the first light portion from an interference pattern that was detected at the at least one light detector, while the measurement unit was providing the first operating condition.

8. The apparatus according to claim 1, further comprising a light modulator configured to be disposed along an optical path along the second light guiding portion and to shift a frequency of light of the first light portion that passes through the light modulator, such that photons of the first light portion that are received at the at least one light detector are frequency modulated with respect to a frequency of the photons when the photons were emitted from the at least one light emitter.

9. The apparatus according to claim 8, wherein the at least one second light guiding unit comprises at least one first optical fiber configured to guide light from the first optical coupler to an entry face of the light modulator, and at least one second optical fiber configured to guide light from an exit face of the light modulator to the second optical coupler.

10. The apparatus according to claim 8, wherein the light modulator is configured to shift the frequency of photons of the first light portion by a first frequency shift, and wherein the acoustic radiation is configured to shift a frequency of the tagged photons of the second light portion by a second frequency shift, the first and second frequency shifts being different from one another.

11. The apparatus according to claim 8, wherein:

by operating at the first operating condition, the measurement unit is configured to generate an interference pattern at the at least one light detector based upon an interaction of the tagged photons of the second light portion, the untagged photons of the second light portion, and the frequency-modulated photons of the first light portion, and

wherein the control unit is configured to determine a property of the tissue of the region of interest based upon analyzing relative amplitudes of respective components of the interference pattern.

12. The apparatus according to claim 8, wherein the measurement unit is configured to operate at the first operating condition by controlling a ratio between a number of photons in the first light portion and a number of tagged photons in the second light portion.

13. A method for performing non-invasive measurements on a subject'"'"'s body, the method comprising:

directing acoustic radiation toward a region of interest within the subject'"'"'s body;

transmitting light from a light emitter to a light detector under a first operating condition, such that;

a first light portion is transmitted from the light emitter to the light detector without passing through tissue of the subject,

a second light portion is transmitted from the light emitter to the light detector via the region of interest within the subject'"'"'s body, such that scattered light of the second light portion that is received at the light detector contains a tagged component corresponding to photons tagged by the acoustic radiation, and an untagged component corresponding to photons untagged by the acoustic radiation,

transmitted light of the first light portion is optically coupled to transmitted light of the second light portion, and

light of the first light portion undergoes an interaction with received light of the second light portion at the light detector, by light of the first light portion that is received at the light detector and light of the second light portion that is received at the light detector being optically coupled to each other;

detecting the light received at the light detector; and

decoupling from each other the tagged and untagged components of the second light portion received at the light detector, based upon the interaction between the light of the first light portion that is received at the light detector and the light of the second light portion that is received at the light detector.

14. The method according to claim 13, wherein transmitting light from the light emitter to the light detector comprises transmitting light through optical fibers.

15. The method according to claim 13, wherein transmitting light from the light emitter to the light detector comprises transmitting light through optical fiber bundles.

16. The method according to claim 13, wherein transmitting light from the light emitter to the light detector comprises transmitting light from the light emitter to the light detector such that light of the first light portion is coherent with light of the second light portion.

17. The method according to claim 13, further comprising:

transmitting light from the light emitter to the light detector under a second operating condition, by blocking the second light portion from arriving at the light detector, and

determining a parameter of light emitted by the light emitter, by analyzing light of the first light portion that was received at the light detector, while the second light portion was blocked.

18. The method according to claim 14, further comprising:

transmitting light from the light emitter to the light detector under a second operating condition, while the acoustic radiation is not being directed toward the region of interest, such that;

the first light portion is transmitted from the light emitter to the light detector without passing through tissue of the subject, and

the second light portion is transmitted from the light emitter to the light detector via the region of interest within the subject'"'"'s body, such that scattered light of the second light portion that is received at the light detector contains photons untagged by the acoustic radiation, and does not contain photons that were tagged by the acoustic radiation, and

determining a property of tissue of the region of interest based upon comparing light received at the light detector while light is transmitted from the light emitter to the light detector at the first operating condition, to light received at the detector while light is transmitted from the light emitter to the light detector at the second operating condition.

19. The method according to claim 13, further comprising:

transmitting light from the light emitter to the light detector under a second operating condition, by blocking the first light portion from arriving at the light detector,

analyzing light that was received at the light detector, while the first light portion was blocked from arriving at the light detector, and

in response thereto, decoupling a contribution of the first light portion from an interference pattern that was detected at the light detector due to the interaction of the first and second light portions, while the light is transmitted from the light emitter to the light detector under the first operating condition.

20. The method according to claim 13, further comprising shifting a frequency of light of the first light portion, such that photons of the first light portion that are received at the light detector are frequency modulated with respect to a frequency of the photons when the photons were emitted from the light emitter.

21. The method according to claim 20, wherein:

shifting the frequency of light of the first light portion comprises shifting the frequency of photons of the first light portion by a first frequency shift, and

directing the acoustic radiation toward the region of interest comprises shifting a frequency of the tagged photons of the second light portion by a second frequency shift,

the first and second frequency shifts being different from one another.

22. The method according to claim 20,

wherein transmitting light from the light emitter to the light detector under the first operating condition comprises generating an interference pattern at the light detector based upon an interaction of the tagged photons of the second light portion, the untagged photons of the second light portion, and the frequency-modulated photons of the first light portion,

the method further comprising determining a property of tissue of the region of interest based upon analyzing relative amplitudes of respective components of the interference pattern.

23. The method according to claim 20, wherein transmitting light from the light emitter to the light detector under the first operating condition, comprises controlling a ratio between a number of photons in the first light portion and a number of tagged photons in the second light portion.