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Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof

  • US 9,132,094 B2
  • Filed: 03/31/2010
  • Issued: 09/15/2015
  • Est. Priority Date: 04/01/2009
  • Status: Active Grant
First Claim
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1. A composition comprising at least one active pharmaceutical ingredient chosen from 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide, at least one phosphate derivative, and at least one polyvinylpyrrolidone derivative compound;

  • wherein said at least one active pharmaceutical ingredient is present in the composition in granular form and wherein the bulk density of the composition is greater than 0.2 g/mL.

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