Encapsulation of pancreatic cells derived from human pluripotent stem cells
First Claim
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1. A device comprising:
- a first cell encapsulation chamber having a lumen; and
a second cell encapsulation chamber having a lumen, wherein said first and second cell encapsulation chambers are sealed at the peripheral edges, wherein said first and second cell encapsulation chambers are separated by at least one separation seal, and wherein the at least one separation seal does not cause an increase in the surface area of the device.
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Abstract
The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
150 Citations
16 Claims
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1. A device comprising:
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a first cell encapsulation chamber having a lumen; and a second cell encapsulation chamber having a lumen, wherein said first and second cell encapsulation chambers are sealed at the peripheral edges, wherein said first and second cell encapsulation chambers are separated by at least one separation seal, and wherein the at least one separation seal does not cause an increase in the surface area of the device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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- 10. A cell encapsulating assembly, said assembly comprising a plurality of chambers, each having a lumen comprising living cells, wherein the assembly comprises a first seal at a peripheral edge of the assembly, thereby forming the cell encapsulating assembly, and at least a second seal, wherein said second seal is within said cell encapsulating assembly, thereby sealing off the cell encapsulation chambers from one another, wherein the living cells comprise human pancreatic and duodenal homeobox gene 1 (PDX1)-positive pancreatic progenitor cells.
Specification