Automatic determination of chronotropic incompetence using atrial pacing at rest

• US 9,132,275 B2
• Filed: 11/07/2011
• Issued: 09/15/2015
• Est. Priority Date: 11/18/2010
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Yu, Yinghong, Hopper, Donald L., Ding, Jiang, Gilkerson, James O.
• Primary Examiner(s): PATTON, AMANDA K
• Application Number:
  US13/290,362
• Publication Number:
  US 20120130440A1
• Time in Patent Office: 1,408 Days
• Field of Search: 607/2
• US Class Current: 1/1
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

An apparatus comprises an implantable cardiac signal sensing circuit that provides an electrical cardiac signal representative of cardiac activity of a subject, an implantable therapy circuit that delivers electrical pacing stimulation energy to a heart of a subject, and a controller circuit. The controller circuit includes a chronotropic incompetence detection circuit that initiates pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate, monitor the AV interval, initiates an increase in the pacing rate while continuing the monitoring of the AV interval, calculates a change in AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring, and indicates that the AV intervals are evidence of chronotropic incompetence when the calculated change in the AV intervals exceeds a specified threshold AV interval change value.

Claims

1. An apparatus comprising:

an implantable cardiac signal sensing circuit configured to provide an electrical cardiac signal representative of cardiac activity of a subject;

an implantable therapy circuit configured to deliver electrical pacing stimulation energy to a heart of a subject; and

a controller circuit, communicatively coupled to the cardiac signal sensing circuit and the therapy circuit, including a chronotropic incompetence detection circuit configured to;

initiate pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate;

monitor a time interval between a paced event in the atrium and a sensed intrinsic event in the ventricle (paced AV interval);

initiate an increase in the pacing rate while continuing the monitoring of the paced AV interval;

calculate a change in paced AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring;

indicate that the paced AV intervals are evidence of chronotropic incompetence when the calculated change in the paced AV intervals exceeds a specified threshold AV interval change value; and

provide an indication of chronotropic incompetence to a user or process.

2. The apparatus of claim 1, wherein the chronotropic incompetence detection circuit is configured to determine a severity of the chronotropic incompetence according to a comparison of the calculated change to a plurality of specified threshold AV interval change values.

3. The apparatus of claim 1, wherein the chronotropic incompetence detection circuit is configured to:

monitor AV intervals as a function of the paced rate;

calculate a slope of the change in AV intervals; and

provide an indication of chronotropic incompetence when the calculated slope exceeds a specified slope value.

4. The apparatus of claim 3, wherein the chronotropic incompetence detection circuit is configured to calculate the slope of the change in AV intervals by calculating a slope of a curve fitted to valid AV interval measurements.

5. The apparatus of claim 3, wherein the chronotropic incompetence detection circuit is configured to:

compare the calculated slope to a plurality of specified AV interval slope values; and

indicate a severity of the chronotropic incompetence of the subject according to the comparison.

6. The apparatus of claim 5, wherein the controller circuit is configured to:

determine a value of a programmable parameter related to adaptive rate pacing according to the indicated severity of chronotropic incompetence; and

provide an alert of chronotropic incompetence of the subject, wherein the alert includes the value of the programmable parameter.

7. The apparatus of claim 6, wherein the parameter related to adaptive rate pacing includes at least one of:

a rate response factor;

a sensitivity of a sensor circuit communicatively coupled to the controller circuit, wherein the sensor circuit provides an electrical signal representative of a physiologic parameter of the subject;

a maximum sensor indicated rate;

a rate-responsive mode of the controller circuit; and

a lower rate limit.

8. The apparatus of claim 5, wherein the controller circuit is configured to:

determine a value of a programmable parameter related to adaptive rate pacing according to the indicated severity of chronotropic incompetence; and

update the programmable parameter to the determined value.

9. The apparatus of claim 5, including:

a memory, communicatively coupled to or integral to the controller circuit, wherein the memory is configured to store an indication of a drug therapy of the subject,

wherein the controller circuit is configured to provide an alert of chronotropic incompetence of the subject, and

wherein the alert includes a recommendation to adjust the drug therapy of the subject according to the indicated severity of chronotropic incompetence.

10. The apparatus of claim 5, wherein the controller circuit is configured to:

recurrently initiate the pacing and monitoring as part of a scheduled chronotropic incompetence detection test, and

change a frequency of initiating the chronotropic incompetence detection test according to the indicated severity of chronotropic incompetence.

11. The apparatus of claim 1, wherein the controller circuit is configured to:

recurrently initiate the pacing and monitoring as part of a scheduled chronotropic incompetence detection test;

detect when the subject is at rest; and

initiate the chronotropic incompetence detection test while the patient is at rest.

12. The apparatus of claim 1, wherein the controller circuit is configured to:

recurrently initiate the pacing and monitoring as part of a scheduled chronotropic incompetence detection test;

detect when the subject is active; and

initiate the chronotropic incompetence detection test while the patient is active.

13. The apparatus of claim 1, wherein the controller circuit is configured to provide an alert that includes a likelihood that the subject has heart disease based on the indication of chronotropic incompetence.

14. The apparatus of claim 1, including:

a sensor circuit communicatively coupled to the controller circuit, wherein the sensor circuit provides an electrical signal representative of a physiologic parameter of the subject, and

wherein the controller circuit is configured to adjust a pacing rate according to the electrical signal provided by the sensor circuit.

15. The apparatus of claim 14, wherein the sensor circuit includes at least one of:

an accelerometer;

an intracardiac impedance sensor;

a transthoracic impedance sensor;

a temperature sensor, wherein the sensor signal is representative of body temperature of the subject; and

the cardiac signal sensing circuit, wherein the sensor signal includes a representation of a depolarization interval that includes a QRS complex.

16. The apparatus of claim 1, wherein the controller circuit is configured to initiate pacing at the device-indicated rate or set the pacing rate below the sensed intrinsic rate when a specified pacing rate is reached during the monitoring or when the AV interval of the subject becomes unstable during the monitoring.

17. The apparatus of claim 1, wherein the chronotropic incompetence detection circuit is configured to continue to increase the pacing and monitor the AV interval until the AV interval of the subject becomes unstable during the monitoring, wherein the controller circuit is configured to store at least one of the rate or the interval at which the atrium is paced when the AV interval becomes unstable, and wherein only AV intervals prior to the AV interval becoming unstable are deemed as valid AV intervals and are used to calculate the change in AV intervals between the highest paced rate and the lowest paced rate used in the monitoring.

18. A method comprising:

pacing an atrium of the subject with an implantable medical device (IMD) while monitoring with the IMD a time interval between a paced event in the atrium and a sensed intrinsic event in the ventricle (paced AV interval), wherein the paced rate is higher than a device-indicated rate or sensed intrinsic rate;

increasing the pacing rate while continuing the monitoring of the paced AV interval;

calculating with the MID a change in paced AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring;

determining with the IMD that the paced AV intervals are evidence of chronotropic incompetence when the calculated change in the paced AV intervals exceeds a specified threshold AV interval change value; and

providing an indication of chronotropic incompetence to a user or process.

19. The method of claim 18, wherein determining that the AV intervals are evidence of chronotropic incompetence includes determining a severity of the chronotropic incompetence according to a comparison of the calculated change to a plurality of specified threshold AV interval change values.

20. The method of claim 18, including:

monitoring AV intervals as a function of paced rate,

wherein calculating a change in the AV intervals includes calculating a slope of the change in AV intervals, and

wherein determining that the AV intervals are evidence of chronotropic incompetence includes determining that the AV intervals are evidence of chronotropic incompetence when the calculated slope exceeds a specified slope value.