Antimicrobial solution and methods of making and using the same

• US 9,132,296 B2
• Filed: 06/30/2014
• Issued: 09/15/2015
• Est. Priority Date: 05/17/2007
• Status: Active Grant

• Current Assignee: Ag Tech, LLC
• Original Assignee: AG Essence
• Inventors: Wingfield, William
• Primary Examiner(s): Bland, Layla
• Assistant Examiner(s): CRAIGO, BAHAR ALAWI
• Application Number:
  US14/319,292
• Publication Number:
  US 20140314820A1
• Time in Patent Office: 442 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 55/02 containing metal atoms
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 5/12 Preparations containing hair conditioners

Abstract

A chitosan solution is formed from chitin, which is a homopolymer of beta (1-4)-linked N-acetyl-D-glucosamine. Rinsed, dried and ground chitin undergoes a process of deacetylation to convert some N-acetyl glucosamine to glucosamine, a primary component of chitosan. The chitosan solution is prepared by mixing 5chitosan with an alpha-hydroxy acid such as glycolic acid. An aqueous chelated silver solution is prepared by mixing silver oxide with a carboxylic acid such as citric acid. The chitosan solution can then be mixed with the silver solution resulting in a cationic complex. The cationic complex of the present invention may then be electrostatically bonded with generally negatively charged surfaces. In use, citrate promotes uptake of the silver by microbes. The antimicrobial complex can be applied via several methods of application, including an impregnated wipe, a foam, a gel, a spray, a lotion and an ointment.

Claims

1. A stable silver oxide-chitosan film forming complex comprising a slurried mixture of a prepared chitosan solution and an aqueous silver oxide solution, wherein said chitosan solution is prepared by thickening an aqueous solution of chitosan with glycolic acid and wherein said aqueous silver solution is a mixture of silver oxide, citric acid, and deionized water, and wherein said complex provides a film at a silver oxide concentration of 75 ppm which is capable of continuing to kill bacteria for 2.5 hours when applied to human skin.

2. The silver oxide-chitosan complex of claim 1, wherein said complex is in the form of one or more products selected from the group consisting of a dryer sheet, laundry detergent, shampoo and/or conditioner, a body wash, carpet shampoo, first aid spray, wound treatment, a hard surface disinfectant, a topical agent, a bio-barrier, and a deodorant.

3. A film forming solution comprising water, an aqueous solution of silver oxide, an aqueous solution of citric acid, and an aqueous solution of chitosan comprising glycolic acid, and wherein said film forming solution provides a film having a silver oxide concentration of 75 ppm which is capable of continuing to kill bacteria for 2.5 hours when applied to human skin.

4. The solution of claim 3, wherein said film forming solution is contained in one or more products selected from the group consisting of a lotion, a gel, a spray, a foam, an impregnated wipe, and an ointment.

5. The solution of claim 3, wherein said film forming solution spreads, binds, absorbs, and provides film integrity on said skin.

6. The solution of claim 3, wherein said film forming solution further comprises a foaming agent selected from the group consisting of an agave derivative, and a salt free surfactant.

7. The solution of claim 3, wherein said film forming solution further comprises a botanical selected from the group consisting of aloe vera and chamomile.