Piperidino-pyrimidine derivatives for the treatment of viral infections

• US 9,133,192 B2
• Filed: 02/07/2013
• Issued: 09/15/2015
• Est. Priority Date: 02/08/2012
• Status: Active Grant

• Current Assignee: Janssen Sciences Ireland UC (Johnson & Johnson)
• Original Assignee: Janssen Sciences Ireland UC (Johnson & Johnson)
• Inventors: McGowan, David Craig, Raboisson, Pierre Jean-Marie Bernard, Jonckers, Tim Hugo Maria, Daoubi Khamlichi, Mourad
• Primary Examiner(s): Balasubramanian, Venkataraman
• Application Number:
  US14/377,064
• Publication Number:
  US 20140350031A1
• Time in Patent Office: 950 Days
• Field of Search: 544/279, 514/264.1
• US Class Current: 1/1
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Claims

1. A compound of formula (I)

2. A compound of formula (I) as claimed in claim 1 wherein R¹ is butyl.

3. A compound of formula (I) as claimed in claim 1 wherein R¹ is C_4-8alkyl substituted with hydroxyl.

4. A compound of formula (I) as claimed in claim 3 wherein R¹ selected from the group consisting of:

5. A compound of formula (I) as claimed in claim 1 wherein X is CH₂.

6. A compound of formula (I) as claimed in claim 1 wherein X is CH₂ and A is CH₂.

7. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, tautomer or solvate thereof as claimed in claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.