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Generation of new pancreatic beta cells

  • US 9,133,440 B2
  • Filed: 10/26/2012
  • Issued: 09/15/2015
  • Est. Priority Date: 09/27/2012
  • Status: Active Grant
First Claim
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1. A method for the generation of new beta cells from pancreatic extra-islet ductal tissue, comprising the steps of:

  • a. culturing pancreatic extra-islet ductal tissue ex vivo; and

    b. contacting said pancreatic extra-islet ductal tissue with a peptide, wherein the peptide consists of an amino acid sequence selected from the group consisting of NVWIGLHDP (SEQ ID NO;

    1), VWIGLHDP (SEQ ID NO;

    4), and WIGLHDP (SEQ ID NO;

    7) and has direct Reg receptor binding activity, and wherein the amount of agent is effective for forming beta cells from said pancreatic extra-islet ductal tissue.

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