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Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene

  • US 9,133,456 B2
  • Filed: 06/05/2014
  • Issued: 09/15/2015
  • Est. Priority Date: 05/28/2009
  • Status: Active Grant
First Claim
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1. A synthetic, modified oligonucleotide of 12 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from:

  • at least one modified sugar moiety;

    at least one modified internucleotide linkage;

    at least one modified nucleotide, and combinations thereof;

    wherein said oligonucleotide is an antisense compound which specifically hybridizes to a natural antisense polynucleotide of an Antiviral gene having SEQ ID NO;

    3 and upregulates the function and/or expression of said Antiviral gene in vivo or in vitro as compared to a normal control.

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