Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
First Claim
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1. A synthetic, modified oligonucleotide of 12 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from:
- at least one modified sugar moiety;
at least one modified internucleotide linkage;
at least one modified nucleotide, and combinations thereof;
wherein said oligonucleotide is an antisense compound which specifically hybridizes to a natural antisense polynucleotide of an Antiviral gene having SEQ ID NO;
3 and upregulates the function and/or expression of said Antiviral gene in vivo or in vitro as compared to a normal control.
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Abstract
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Antiviral gene, in particular, by targeting natural antisense polynucleotides of an Antiviral gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Antiviral genes.
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17 Claims
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1. A synthetic, modified oligonucleotide of 12 to 30 nucleotides in length comprising at least one modification wherein the at least one modification is selected from:
- at least one modified sugar moiety;
at least one modified internucleotide linkage;
at least one modified nucleotide, and combinations thereof;
wherein said oligonucleotide is an antisense compound which specifically hybridizes to a natural antisense polynucleotide of an Antiviral gene having SEQ ID NO;
3 and upregulates the function and/or expression of said Antiviral gene in vivo or in vitro as compared to a normal control. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- at least one modified sugar moiety;
Specification