Optical measurements of properties in substances using propagation modes of light

• US 9,134,231 B2
• Filed: 10/08/2013
• Issued: 09/15/2015
• Est. Priority Date: 06/04/2003
• Status: Active Grant

• Current Assignee: Tomophase Corporation
• Original Assignee: Tomophase Corporation
• Inventors: Wang, Feiling
• Primary Examiner(s): Nur, Abdullahi
• Application Number:
  US14/049,196
• Publication Number:
  US 20150098082A1
• Time in Patent Office: 707 Days
• Field of Search: 356/300, 356/445, 356/369
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: G01B 2290/40 Non-mechanical variable delay line
• CPC Class Codes: G01B 2290/70 Using polarization in the interferometer
• CPC Class Codes: G01B 9/02057 by using common path configuration, i.e. reference and object path almost entirely overlapping
• CPC Class Codes: G01B 9/0209 Low-coherence interferometers
• CPC Class Codes: G01N 21/27 using photo-electric detection G01N21/31 takes precedence; circuits for computing concentration logarithmic circuits G06G7/24; photometric circuits in general G01J
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/55 Specular reflectivity

Abstract

This application describes designs, implementations, and techniques for controlling propagation mode or modes of light in a common optical path, which may include one or more waveguides, to sense a sample.

Claims

1. A method for optically measuring a sample, comprising:

directing one beam of guided light in a first propagation mode to a sample;

directing a first portion of the guided light in the first propagation mode at a location near the sample away from the sample before the first portion reaches the sample while allowing a second portion in the first propagation mode to reach the sample;

controlling a reflection of the second portion from the sample to be in a second propagation mode different from the first propagation mode to produce a reflected second portion; and

directing both the reflected first portion in the first propagation mode and the reflected second portion in the second propagation mode through a common waveguide into a detection module to extract information from the reflected second portion on the sample.

2. The method as in claim 1, wherein the first propagation mode and the second propagation mode are two polarization modes that are orthogonal to each other.

3. The method as in claim 2, wherein the first propagation mode and the second propagation mode are two orthogonal linear polarization modes.

4. The method as in claim 2, further comprising using a polarization rotator to cause the reflected second portion to be in the second propagation mode.

5. The method as in claim 2, further comprising using a Faraday rotator to cause the reflected second portion to be in the second propagation mode.

6. The method as in claim 2, further comprising using a quarter wave plate to cause the reflected second portion to be in the second propagation mode.

7. The method as in claim 1, further comprising using the common waveguide to both direct the guided light to the sample and to guide the reflected first portion and the reflected second portion away from the sample.

8. The method as in claim 7, wherein the waveguide is a polarization maintaining waveguide.

9. The method as in claim 7, wherein the waveguide is a polarization maintaining fiber.

10. The method as in claim 1, further comprising using an input waveguide different from the common waveguide to direct the guided light to the sample.

11. The method as in claim 1, further comprising adjusting a relative phase delay between the reflected first portion and the reflected second portion.

12. The method as in claim 1, further comprising:

mixing energy of the first propagation mode and the second propagation mode in the detection module to produce a first optical signal and a second optical signal; and

detecting the first and second optical signals to extract the information of the sample.

13. The method as in claim 12, further comprising using a difference between the first optical signal and the second optical signal to extract the information of the sample.

14. The method as in claim 13, further comprising:

modulating a relative phase delay between the reflected first portion and the reflected second portion at a modulation frequency; and

using information on amplitudes of the difference at the modulation frequency and a harmonic of the modulation frequency to extract the information of the sample.

15. The method as in claim 12, further comprising:

separating different optical spectral components in the first optical signal;

measuring the different optical spectral components in the first optical signal;

separating different optical spectral components in the second optical signal;

measuring the different optical spectral components in the second optical signal; and

using the measurements to obtain a spectral response of the sample at a spectral component selected from the different optical spectral components.

16. The method as in claim 15, further comprising using an optical grating to separate the different optical spectral components in the first optical signal by optical diffraction.

17. The method as in claim 1, further comprising controlling a spectral property of the guided light to the sample to obtain the information of the sample.

18. The method as in claim 1, further comprising using a tunable optical bandpass filter to select a center wavelength of a spectral range of the guided light to the sample to obtain a spectral response of the sample in the spectral range.

19. A device for optically measuring a sample, comprising:

a waveguide to receive and guide an input beam in a first propagation mode;

a probe head coupled to the waveguide to receive the input beam and to reflect a first portion of the input beam back to the waveguide in the first propagation mode and direct a second portion of the input beam to a sample, the probe head collecting reflection of the second portion from the sample and exporting to the waveguide the reflection as a reflected second portion in a second propagation mode different from the first propagation mode; and

a detection module to receive the reflected first portion and the reflected second portion in the waveguide and to extract information of the sample carried by the reflected second portion.

20. A method for optically measuring a sample, comprising:

directing light in a first propagation mode to a vicinity of a sample under measurement;

directing a first portion of the light in the first propagation mode to propagate away from the sample at the vicinity of the sample without reaching the sample;

directing a second portion of the light in the first propagation mode to the sample to cause reflection at the sample;

controlling reflected light from the sample to be in a second propagation mode that is independent from the first propagation mode to co-propagate with the first portion along a common optical path; and

using the first portion in the first propagation mode and the reflected light in the second propagation mode to obtain information of the sample.