Method and apparatus for selective photothermolysis of veins

• US 9,138,294 B2
• Filed: 07/23/2013
• Issued: 09/22/2015
• Est. Priority Date: 01/16/2007
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Anderson, Richard R., Farinelli, William A., Rubin, Iris Kedar
• Primary Examiner(s): Farah, Ahmed
• Assistant Examiner(s): LIPITZ, JEFFREY BRIAN
• Application Number:
  US13/948,971
• Publication Number:
  US 20130310818A1
• Time in Patent Office: 791 Days
• Field of Search: 606/9, 606/49
• US Class Current: 1/1
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: A61N 2005/0659 infrared

Abstract

A system and method are provided that are capable of selectively treating a vein using photothermolysis techniques, where an electromagnetic radiation is applied to tissue containing the vein. The radiation can be selected so that it may be more effectively absorbed by veins as compared to arteries. Thus, unwanted thermal damage to arteries in the vicinity of the vein being treated can be reduced or avoided. The radiation can have a frequency of approximately 654 nm, which can provide a ratio of absorption by veins to absorption by arteries of about 3.7. Other wavelengths near 654 nm may be provided, for example, which can have an absorption ratio greater than, e.g., about 3.3 to 3.6.

Claims

1. A method for treating a region of interest (ROI) of a patient'"'"'s body, the method comprising:

identifying an ROI of skin of the patient'"'"'s body, said identified ROI including at least one venous malformation;

treating the identified ROI with light having an operational wavelength at which blood in a typical vein in human skin has an absorption coefficient that at least 3.7 times higher than an absorption coeffiecient of a typical artery in human skin such as to photocoagulate a vein by selective photothermolysis of the at least one venous malformation while avoiding damage to an artery within the skin of the ROI;

said blood containing about 30 percent deoxyhemoglobin and about 70 percent oxyhemoglobin.

2. A method according to claim 1, wherein said treating includes causing thermal damage to the vein in the at least one venous malformation with light generated by a pulsed light source.

3. A method according to claim 1, wherein the treating includes treating the identified ROI at an operational wavelength at which blood in a typical vein in the skin is characterized by an absorption ratio of a first absorption coefficient of a deoxygenated hemoglobin to a second absorption coefficient of an oxygenated hemoglobin, said absorption ratio being greater than 10.

4. A method according to claim 1, wherein the treating includes treating the identified ROI at an operational wavelength at which blood in a typical vein in the skin is characterized by an absorption ratio of a first absorption coefficient of a typical deoxygenated hemoglobin of blood to a second absorption coefficient of an typical oxygenated hemoglobin of blood, said absorption ratio being greater than 10.2.

5. A method according to claim 1, wherein the treating includes treating the identified ROI with light such as to eliminate or reduce perfusion in the at least one venous malformation.

6. A method according to claim 1, wherein the treating includes treating the identified ROI with fluences between about 20 J/cm^2 and about 80 J/cm^2.

7. A method according to claim 1, wherein the treating includes treating at least one of a varicose vein and a port wine stain.

8. A method according to claim 1, wherein the treating includes treating the identified ROI with light from at least one of a pulsed dye laser, a wavelength-shifted Nd:

YAG laser, a frequency-doubled infrared laser, a high power diode laser array, and a fiber laser.

9. A method according to claim 1, further comprising cooling a surface of said ROI.