Mucosal tissue adhesion via textured surface

• US 9,138,308 B2
• Filed: 08/02/2012
• Issued: 09/22/2015
• Est. Priority Date: 02/03/2010
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Apollo Endosurgery, Inc. (Boston Scientific Corporation)
• Inventors: Schwab, Justin J., Raven, Joseph S., Liu, Futian
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US13/565,670
• Publication Number:
  US 20130197661A1
• Time in Patent Office: 1,146 Days
• Field of Search: 623 2364- 2365
• US Class Current: 1/1
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/6871 Stomach
• CPC Class Codes: A61B 5/6879 Means for maintaining contact with the body A61B5/6847 takes precedence
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2002/045 Stomach, intestines
• CPC Class Codes: A61L 2400/08 Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution
• CPC Class Codes: A61L 27/165 Rubbers
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/049 Rubbers
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: B29C 41/02 for making articles of definite length, i.e. discrete articles
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: C08L 9/06 Copolymers with styrene

Abstract

The present specification discloses porous materials, methods of forming such porous material, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices. The porous material may be used to fix to the interior mucosal lining of a patient'"'"'s gastrointestinal tract.

Claims

1. A method for anchoring an implant device to a mucosal lining of a patient'"'"'s gastrointestinal tract comprising:

inserting a pre-formed implant device into the patient'"'"'s gastrointestinal lumen, which defines a passage that allows for passage therethrough of the pre-formed implant and food, at least a portion of the implant device being formed of a substantially non-resorbable, biocompatible, elastomer matrix defining an array of interconnected pores structured to receive tissue ingrowth from the mucosal lining of the patient'"'"'s gastrointestinal lumen to anchor the implant device to the mucosal lining; and

placing the implant device within the passage defined by the patient'"'"'s gastrointestinal lumen such that the array of interconnected pores contacts the mucosal lining such that the implant rests against the mucosal lining and extends into the passage defined by the gastrointestinal lumen and receives tissue ingrowth from the mucosal lining to anchor the implant device to the mucosal lining.

2. The method of claim 1, wherein the step of placing includes pressing the array of interconnected pores against the mucosal lining.

3. The method of claim 1, wherein the step of inserting includes inserting the implant device into the patient'"'"'s gastrointestinal tract with an endoscopic device.

4. The method of claim 1, wherein the step of inserting includes inserting the implant device into the patient'"'"'s esophagus through the patient'"'"'s mouth or inserting the implant device into the patient'"'"'s large intestine through the patient'"'"'s anus.

5. The method of claim 1, wherein the step of placing includes suturing the implant device to the patient'"'"'s gastrointestinal tract such that the array of interconnected pores contacts the mucosal lining.

6. The method of claim 1, wherein the array of interconnected pores forms an outer surface of the implant device.

7. The method of claim 1, wherein each of the pores of the array of interconnected pores has a size of between about 30 microns to about 1000 microns.

8. The method of claim 1, wherein the elastomer matrix has a porosity of between about 10% to about 80%.

9. The method of claim 1, wherein the elastomer matrix is a silicone-based elastomer matrix.

10. The method of claim 1, wherein the implant device is selected from a group consisting of a stent, a drug elution device, a tissue graft, an intragastric volume occupying device, a sensor, a device structured to form a stoma within the gastrointestinal tract, and combinations thereof.

11. A method for anchoring an implant device to a mucosal lining of a patient'"'"'s gastrointestinal tract comprising:

inserting a pre-formed implant device into the patient'"'"'s gastrointestinal lumen, which defines a passage that allows for passage therethrough of the pre-formed implant and food, at least a portion of the implant device being formed of a substantially non-resorbable, biocompatible, elastomer matrix defining an array of interconnected pores structured to receive tissue ingrowth from the mucosal lining of the patient'"'"'s gastrointestinal lumen to anchor the implant device to the mucosal lining; and

placing the implant device within the passage defined by the patient'"'"'s gastrointestinal lumen such that the array of interconnected pores contacts the mucosal lining such that the implant does not extend into the mucosal lining and receives tissue ingrowth from the mucosal lining to anchor the implant device to the mucosal lining.

12. The method according to claim 11, wherein the implant is placed such that it does not pass through a surface of the mucosal lining.

13. A method for anchoring an implant device to a mucosal lining of a patient'"'"'s gastrointestinal tract comprising:

inserting a pre-formed implant device into the patient'"'"'s gastrointestinal lumen, which defines a passage that allows for passage therethrough of the pre-formed implant and food, without cutting any tissue of the patient, at least a portion of the implant device being formed of a substantially non-resorbable, biocompatible, elastomer matrix defining an array of interconnected pores structured to receive tissue ingrowth from the mucosal lining of the patient'"'"'s gastrointestinal lumen to anchor the implant device to the mucosal lining; and

placing the implant device within the passage defined by the patient'"'"'s gastrointestinal lumen such that the array of interconnected pores contacts the mucosal lining and receives tissue ingrowth from the mucosal lining to anchor the implant device to the mucosal lining.