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PEG-interferon-beta formulations

  • US 9,138,403 B2
  • Filed: 12/18/2008
  • Issued: 09/22/2015
  • Est. Priority Date: 12/20/2007
  • Status: Expired due to Fees
First Claim
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1. A liquid pharmaceutical composition comprising an interferon-β

  • pegylated with polyethylene glycol (PEG) having a molecular weight of at least 20kDa (PEG-IFN-β

    ), a polyol excipient at a concentration of about 30 mg/ml to about 50 mg/ml, a poloxamer surfactant and a sodium acetate buffer, wherein the pH of the pharmaceutical composition is 4.2 ±

    0.2, and wherein the poloxamer surfactant is poloxamer 188.

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