PEG-interferon-beta formulations
First Claim
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1. A liquid pharmaceutical composition comprising an interferon-β
- pegylated with polyethylene glycol (PEG) having a molecular weight of at least 20kDa (PEG-IFN-β
), a polyol excipient at a concentration of about 30 mg/ml to about 50 mg/ml, a poloxamer surfactant and a sodium acetate buffer, wherein the pH of the pharmaceutical composition is 4.2 ±
0.2, and wherein the poloxamer surfactant is poloxamer 188.
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Abstract
The invention relates to a liquid pharmaceutical composition comprising a pegylated IFN-β (PEG-IFN-β), an excipient, a surfactant and a buffer wherein said excipient is a polyol, wherein said surfactant is a non-ionic surfactant and wherein said buffer is a sodium acetate buffer.
38 Citations
29 Claims
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1. A liquid pharmaceutical composition comprising an interferon-β
- pegylated with polyethylene glycol (PEG) having a molecular weight of at least 20kDa (PEG-IFN-β
), a polyol excipient at a concentration of about 30 mg/ml to about 50 mg/ml, a poloxamer surfactant and a sodium acetate buffer, wherein the pH of the pharmaceutical composition is 4.2 ±
0.2, and wherein the poloxamer surfactant is poloxamer 188. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
- pegylated with polyethylene glycol (PEG) having a molecular weight of at least 20kDa (PEG-IFN-β
Specification