Collagen/hydroxyapatite composite scaffold, and process for the production thereof
First Claim
1. A collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, collagen matrix, wherein the ratio of HA to collagen ranges from 1:
- 10 (w/w) to 50;
10 (w/w), and wherein composite scaffold has a porosity of at least 97% (v/v) and a compressive stiffness of at least 0.4 KPa, wherein the composite scaffold further comprising a cell.
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Abstract
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilizing the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w). Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3 KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
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Citations
15 Claims
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1. A collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, collagen matrix, wherein the ratio of HA to collagen ranges from 1:
- 10 (w/w) to 50;
10 (w/w), and wherein composite scaffold has a porosity of at least 97% (v/v) and a compressive stiffness of at least 0.4 KPa, wherein the composite scaffold further comprising a cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- 10 (w/w) to 50;
Specification