Automatic injection device with torsional spring

• US 9,138,542 B2
• Filed: 02/15/2011
• Issued: 09/22/2015
• Est. Priority Date: 02/17/2010
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Smith, Christopher James
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): STILES, AMBER R.
• Application Number:
  US13/579,081
• Publication Number:
  US 20130096513A1
• Time in Patent Office: 1,680 Days
• Field of Search: 604/131, 604134-135, 604/187, 604207-208, 604211-212, 604/214, 604/218, 604/232, 604/246
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/202 cocking means, e.g. to bias the main drive spring of an injector
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/31543 piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

A semi-automatic “fixed” dose injection device is disclosed containing a reservoir of medicament, where a trigger controls the unwinding of a torsional spring to cause a predetermined injection of medicament from the reservoir through a disposable needle.

Claims

1. A fixed dose injection device comprising the following in combination,

a. a housing;

and

b. a dose setting and injecting assembly comprising,

i. a rotatable gear having only at least two teeth offset from each other at an angle α

that corresponds to only one predetermined fixed dose of medicament, where the rotatable gear is fixed axially in the housing;

ii. a plunger threadedly engaged with the rotatable gear having a pitch β

that is matched with angle α

so that the plunger moves distally during dose delivery a distance corresponding to the only one predetermined fixed dose;

iii. a torsional spring, and a drive shaft wherein the torsional spring rotates the drive shaft back to a zero position if the drive shaft is rotated by an angle smaller than α

during dose dialing such that dialing doses smaller than the only one predetermined fixed dose is prevented;

iv. a trigger connected to the rotatable gear such that when the trigger is activated the torsional spring unwinds and causes the rotatable gear to rotate through angle α and

to move the plunger distally to deliver the only one predetermined fixed dose; and

v. a rotation stop that limits the rotation of the drive shaft, allowing a rotation beyond one tooth and preventing a rotation beyond more than one tooth of the rotatable gear such that setting a dose exceeding the only one predetermined fixed dose is prevented.

2. The injection device of claim 1 wherein a medicament housing is connected to the housing and holds a cartridge of medicament.

3. The injection device of claim 1 wherein the angle α

is from 20 degrees to 180 degrees.

4. The injection device of claim 1 wherein a ratio of α

/β

is in the range from 10 to 20 degrees/mm.

5. The injection device of claim 1 wherein the pitch β

of a thread on the plunger is from 1.5 mm to 12 mm.

6. The injection device of claim 1 wherein the drive shaft comprises a ratchet arm that engages one of the teeth during dose setting.

7. The injection device of claim 1 wherein the drive shaft comprises a ratchet arm that is configured to engage one of the teeth during dose setting.

8. A fixed dose injection device comprising the following in combination,

a. a housing comprising a removable cartridge holder configured to contain a cartridge of medicament;

and

b. a dose setting and injecting assembly comprising,

i. a rotatable gear having only two teeth offset from each other at an angle α

that corresponds to only one predetermined fixed dose of medicament, where the rotatable gear is fixed axially in the housing;

ii. a plunger threadedly engaged with the rotatable gear having a pitch β

that is matched with angle α

so that the plunger moves distally during dose delivery a distance corresponding to the predetermined fixed dose;

iii. a torsional spring, and a drive shaft wherein the torsional spring rotates the drive shaft back to a zero position if the drive shaft is rotated by an angle smaller than α

;

iv. a trigger connected to the rotatable gear such that when the trigger is activated the torsional spring unwinds and causes the rotatable gear to rotate through angle α and

to move the plunger distally to deliver the predetermined fixed dose;

and

vi. a reset dial configured to prevent rotation of the plunger and to allow the plunger to be retracted proximally into the housing when the cartridge holder is removed.

9. A fixed dose titration injection device comprising the following in combination,

a. a housing comprising a removable cartridge holder configured to contain a cartridge of medicament;

and

b. a dose setting and injecting assembly comprising,

i. a rotatable gear having only a first, a second, and a third tooth offset from each other at an angle α

that corresponds to only one predetermined fixed dose of medicament such that only three injections of medicament can be performed using the cartridge of medicament, where the rotatable gear is fixed axially in the housing;

ii. a drive shaft having a ratchet arm that is configured to engage either the first, the second or the third tooth during dose setting;

iii. a plunger threadedly engaged with the rotatable gear having a pitch β

that is matched with angle α

so that the plunger moves distally during dose delivery a distance corresponding to one or more multiples of the predetermined fixed dose;

iv. a torsional spring wherein the torsional spring rotates the drive shaft back until the ratchet arm engages at the next gear tooth, corresponding to the next lower dose, if a dose is dialed in between two fixed titration doses; and

v. a trigger connected to the rotatable gear such that when the trigger is activated the torsional spring unwinds and causes the rotatable gear to rotate through one or more multiples of angle α and

to move the plunger distally to deliver the one or more multiples of the predetermined fixed dose,

and

vii. a reset dial configured to prevent rotation of the plunger and to allow the plunger to be retracted proximally into the housing when the cartridge holder is removed.