Interferon-antibody fusion proteins demonstrating potent apoptotic and anti-tumor activities
First Claim
1. A method of inhibiting growth and/or proliferation of a cancer cell, said method comprising contacting said cancer cell with a chimeric construct comprising a type I interferon attached to a full-length antibody that binds to a tumor-associated antigen, wherein said antibody is attached to said interferon by a peptide linker that is resistant to proteolysis, wherein the amino acid sequence of said peptide linker is SGGGGS (SEQ ID NO:
- 62) or AEAAAKEAAAKAGS (SEQ ID NO;
63).
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Accused Products
Abstract
This invention provides novel chimeric moieties that show significant efficacy against cancers. In certain embodiments the chimeric moieties comprise a targeting moiety attached to an interferon. In certain embodiments, the chimeric moieties comprise fusion proteins where an antibody that specifically binds to a cancer marker is fused to interferon alpha (IFN-α).
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Citations
16 Claims
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1. A method of inhibiting growth and/or proliferation of a cancer cell, said method comprising contacting said cancer cell with a chimeric construct comprising a type I interferon attached to a full-length antibody that binds to a tumor-associated antigen, wherein said antibody is attached to said interferon by a peptide linker that is resistant to proteolysis, wherein the amino acid sequence of said peptide linker is SGGGGS (SEQ ID NO:
- 62) or AEAAAKEAAAKAGS (SEQ ID NO;
63). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- 62) or AEAAAKEAAAKAGS (SEQ ID NO;
Specification