Method and apparatus for delivering an agent to a kidney

• US 9,144,509 B2
• Filed: 10/12/2010
• Issued: 09/29/2015
• Est. Priority Date: 05/31/2007
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Consigny, Paul M., Gale, David C., Ludwig, Florian, El-Nounou, Fozan O., Kramer-Brown, Pamela A., Yribarren, Travis R., Webler, William E. Jr., von Oepen, Randolpf
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US12/902,405
• Publication Number:
  US 20110190698A1
• Time in Patent Office: 1,813 Days
• Field of Search: 604/133, 604/103.01, 604/27, 604/93.01, 604/103.07, 604/131, 604/509, 623/1.42, 623/1.2
• US Class Current: 1/1
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.

Claims

1. A device comprising a catheter including:

a main body having a diffusion member delivery lumen through which a self-expandable diffusion member dimensioned for insertion within a blood vessel is advanced, the self-expandable diffusion member comprising a body, wherein the body comprises at least one fluid passage dimensioned to allow a blood flow within the vessel to flow through the body and create a region of turbulent blood flow within the blood vessel, and

a drug delivery lumen positioned upstream to the self-expandable diffusion member, and wherein the drug delivery lumen is positioned around the diffusion member delivery lumen and configured such that a drug delivered through the drug delivery lumen flows through the at least one fluid passage of the self-expandable diffusion member and mixes with the blood in the region of turbulent blood flow.

2. The device of claim 1 wherein the self-expandable diffusion member comprising a body comprises a pre-formed shape memory material.

3. The device of claim 2 wherein the pre-formed shape memory material comprises nitinol.

4. The device of claim 1 wherein the self-expandable diffusion member comprising a body comprises a net-like, braided structure.

5. The device of claim 4 wherein the net-like, braided structure comprises one, two, or more wires or filaments.

6. The device of claim 1 wherein the self-expandable diffusion member comprising a body comprises a donut structure.

7. The device of claim 6 wherein the donut structure comprises a substantially cylindrical body with a length, a largest diameter, and wherein the passage is coaxial to the cylindrical axis.

8. The device of claim 7 wherein the length ranges from one to ten times the largest diameter of the body.

9. The device of claim 8 wherein the body has a diameter of 50-105% of the vessel.

10. The device of claim 9 wherein the passage has a diameter that ranges from 15-80% of the largest diameter of the cylinder.

11. The device of claim 10 further comprising a connecting member that joins the main body to the expandable diffusion member comprising a body.

12. The device of claim 7 further comprising a connecting member that joins the main body to the expandable diffusion member comprising a body.

13. The device of claim 12 wherein the length ranges from one to ten times the largest diameter of the body.

14. The device of claim 13 wherein the body has a diameter of 50-105% of the vessel.

15. The device of claim 7 wherein the body has a diameter of 50-105% of the vessel.

16. The device of claim 7 wherein the passage has a diameter that ranges from 15-80% of the largest diameter of the cylinder.

17. The device of claim 1 wherein the self-expandable diffusion member has a body with a length wherein the length ranges from one to ten times the largest diameter of the body.

18. The device of claim 1 wherein the self-expandable diffusion member comprising a body further comprises a ball of wire or filament.

19. The device of claim 18 wherein the ball of wire or filament comprises a set of coplanar serpentine curves.

20. The device of claim 1 wherein the self-expandable diffusion member comprising a body further comprises an occlusion balloon.