Oral dosage form for controlled drug release
DCFirst Claim
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1. A tablet oral dosage form comprising:
- (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and
(ii) a pH-dependent erodable coating around said core, which coating has a thickness in the range 0.05 to 0.5 mm and comprises one or more openings, wherein said openings are circular, drilled openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core and have a diameter in the range 0.5 mm to 8 mm, wherein said openings comprise about 10 to 70% of the total face area of the dosage form;
wherein release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs;
through the one or more openings by the erosion of said erodable core andthrough erosion of said erodable coating at pH>
4.5, wherein said erodable coating dissolves at pH>
4.5 to expose all of said core to erosion.
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Abstract
An oral dosage form comprising,
- (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and
- (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core;
characterized in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.
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8 Claims
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1. A tablet oral dosage form comprising:
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(i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) a pH-dependent erodable coating around said core, which coating has a thickness in the range 0.05 to 0.5 mm and comprises one or more openings, wherein said openings are circular, drilled openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core and have a diameter in the range 0.5 mm to 8 mm, wherein said openings comprise about 10 to 70% of the total face area of the dosage form; wherein release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs; through the one or more openings by the erosion of said erodable core and through erosion of said erodable coating at pH>
4.5, wherein said erodable coating dissolves at pH>
4.5 to expose all of said core to erosion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification