Compositions and methods for modulating HBV expression
First Claim
Patent Images
1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 20 contiguous nucleobases complementary to an equal length portion of nucleobases 1583 to 1602 of SEQ ID NO:
- 1, wherein the nucleobase sequence of the modified oligonucleotide is 100% complementary to SEQ ID NO;
1; and
wherein the conjugate group comprises;
3 Assignments
0 Petitions
Accused Products
Abstract
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
143 Citations
24 Claims
-
1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 20 contiguous nucleobases complementary to an equal length portion of nucleobases 1583 to 1602 of SEQ ID NO:
- 1, wherein the nucleobase sequence of the modified oligonucleotide is 100% complementary to SEQ ID NO;
1; and
wherein the conjugate group comprises;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
- 1, wherein the nucleobase sequence of the modified oligonucleotide is 100% complementary to SEQ ID NO;
Specification