System for measuring vital signs using bilateral pulse transit time

• US 9,149,192 B2
• Filed: 05/26/2006
• Issued: 10/06/2015
• Est. Priority Date: 05/26/2006
• Status: Active Grant

• Current Assignee: Sotera Wireless Incorporated
• Original Assignee: Sotera Wireless Incorporated
• Inventors: Banet, Matthew John, Thompson, Michael James, Zhou, Zhou, Visser, Henk II, Hunt, Robert Kenneth
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): MESSERSMITH, ERIC J
• Application Number:
  US11/420,652
• Publication Number:
  US 20070276632A1
• Time in Patent Office: 3,420 Days
• Field of Search: 600300-301, 600/485, 600/500, 600/504, 600/507
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 2560/0468 Built-in electrodes
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

The invention provides a monitor for measuring blood pressure and other vital signs from a patient without using a cuff. The invention provides a hand-held device for measuring vital signs (e.g. blood pressure) from a patient that features: i) a housing that encloses a first sensor, that includes a first electrode and a first optical system configured to generate a first optical signal; ii) a second sensor that includes a second electrode and a second optical system configured to generate a second optical signal; iii) an amplifier system, in electrical contact with the first and second electrodes, configured to processes electrical signals from the first and second electrodes to generate an electrical waveform; and iv) a microprocessor, in electrical communication with the amplifier system, first optical system, and second optical system, the microprocessor configured to process the electrical waveform and first and second optical signals with an algorithm to determine at least one of the patient'"'"'s vital signs.

Claims

1. A method for calculating blood pressure from a patient, said method comprising:

detecting an electrical waveform corresponding to the electrical activity of the patient'"'"'s heart with a first sensor comprising a first electrode located at a first location on a subject and a second electrical signal measured by a second electrode located at a second location on the subject, the first and second electrodes operably connected to an amplifier system that generates the electrical waveform from the electrical activity which is detected by the first and second waveforms;

detecting a first pulse waveform with a second sensor located on a hand of the subject;

detecting a second pulse waveform with a third sensor located on the opposite hand of the subject;

transmitting the electrical waveform, the first pulse waveform, and the second pulse waveform to a microprocessor; and

processing the electrical waveform, the first pulse waveform, and the second pulse waveform by using the microprocessor to (i) identify a first feature in the electrical waveform corresponding to a heartbeat, (ii) identify a second feature in the first pulse waveform corresponding to the heartbeat, (iii) identify a third feature in the second pulse waveform corresponding to the heartbeat, (iv) calculate a first time difference between the first feature and the second feature, (v) calculate a second time difference between the first feature and the third feature;

(vi) calculate a third time difference between the first time difference and the second time difference and (vii) calculate the subject'"'"'s blood pressure using the third time difference and an algorithm relating the third time difference to blood pressure.

2. The method of claim 1, wherein the the second and third sensor each comprises an optical system configured to generate a photoplethysmogram.

3. The method of claim 2, wherein the optical system comprises a light source and a photodetector on a common substrate.

4. The method of claim 3, wherein the photodetector is configured to receive radiation from the light source after it reflects off one of the patient'"'"'s fingers.

5. The method of claim 1, wherein the first and second pulse waveform are each an optical waveform.

6. The method of claim 1, further comprising calculating a blood pressure with a microprocessor configured to process at least one of the electrical waveform and first optical signal, or at least one derivative thereof, to determine a heart rate.

7. The method of claim 1, further comprising transmitting information with a wireless system configured to wirelessly transmit at least one of the patient'"'"'s vital signs to an external receiver.