Light-based method for the endovascular treatment of pathologically altered blood vessels

• US 9,149,334 B2
• Filed: 10/25/2010
• Issued: 10/06/2015
• Est. Priority Date: 04/25/2008
• Status: Active Grant

• Current Assignee: Dornier MedTech Systems GmbH
• Original Assignee: Dornier MedTech Systems GmbH
• Inventors: Beck, Tobias, Meier, Richard
• Primary Examiner(s): ROANE, AARON F
• Application Number:
  US12/911,613
• Publication Number:
  US 20110125140A1
• Time in Patent Office: 1,807 Days
• Field of Search: 606 2- 19, 607/88, 607/89
• US Class Current: 1/1
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2018/20361 with redirecting based on sensed condition, e.g. tissue analysis or tissue movement
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61B 90/37 Surgical systems with images on a monitor during operation

Abstract

A light-based method of endovascular treatment, in particular, of pathologically altered blood vessels. Provided are a Method of Endovascular Light Treatment and a corresponding Endovascular Light Application Device.

Claims

1. A blood vessel treatment device, comprising:

a light applicator; and

a catheter, comprising a sheath, via which the light applicator is inserted into and guided within a blood vessel, wherein the sheath is flexible and non-expandable in the radial direction along an entire length of the sheath, wherein the catheter is open at a proximal end of the catheter, and wherein the catheter is closed at a distal portion of the catheter; and

wherein the catheter and the light applicator are arranged and adapted such that, at any time during use, the light applicator does not make intraluminal contact with any vessel wall and the light applicator is capable of delivering light energy through a sheath of the catheter so as to emit light energy and cause damage to a vessel wall of the blood vessel, the damage resulting in a subsequent decrease in a diameter of the blood vessel,

during use, the light applicator is movable within the catheter in consecutive segments or at a constant velocity of 1-5 mm/s, and

during use, the light applicator may be placed repeatedly at the same position within the vessel without moving the catheter.

2. The device of claim 1, further comprising a light emitting unit, said light emitting unit being connected to the light applicator.

3. The device of claim 1, wherein the light energy is laser light energy of a wavelength in the range 500-2000 nm.

4. The device of claim 1, wherein the light applicator is placed within the sheath of the catheter.

5. The device of claim 1, wherein the light applicator is capable of delivering light energy to the blood vessel using the Seldinger Technique or a kind of Seldinger Technique.

6. The device of claim 1, wherein

a diameter of the light applicator is between 0.1 and 2.5 mm,

a length of a light emitting surface of the light applicator is between 3 to 70 mm, and

a power density of the emitting surface of the light applicator is between 10 to 100 W/cm².

7. The device of claim 1, wherein the light applicator comprises a fiber optic line and cylindrical diffuser.

8. The device of claim 7, wherein

the cylindrical diffuser emits light in an inhomogeneous profile such that more light energy is provided at a distal end than a non-distal end of the light applicator.

9. The device of claim 7, wherein the cylindrical diffuser emits light in a homogeneous profile over the surface of the cylindrical diffuser.

10. The device of claim 7, wherein

the entire sheath of the catheter comprises a tubular envelope of consistent diameter, and

a distal end of the catheter is closed by a closure, a diameter of the closure being substantially equivalent to the diameter of the sheath of the catheter.

11. The device of claim 1, wherein the light applicator emits light in a cylindrical radiation profile.

12. The device of claim 1, further comprising at least one of:

a contrast unit that captures images of the blood vessel to be treated;

a velocity control unit that controls a velocity at which the light applicator is moved within the catheter;

a temperature detecting unit that determines a temperature at a position where the blood vessel is to be damaged;

a coagulation detecting unit that determines coagulation at a position where the blood vessel is to be damaged;

an imaging unit that displays the data measured by at least one of the contrast unit, the velocity control unit, the temperature detecting unit, and the coagulation detecting unit; and

a closed loop unit that controls at least one of the parameters of light intensity, velocity, and segmentation of movement.

13. The device of claim 1, further comprising:

a velocity control unit that controls a velocity at which the light applicator is moved within the catheter; and

a temperature detecting unit that determines a temperature at a position where the blood vessel is to be damaged.

14. A kit, comprising:

a light applicator;

a catheter via which the light applicator is inserted into and guided within a blood vessel; and

an access needle;

wherein the catheter and the light applicator are arranged and adapted such that, at any time during use, the light applicator does not make intraluminal contact with any vessel wall and the light applicator is capable of delivering light energy through the catheter to emit light energy and cause damage to a vessel wall of the blood vessel, and

a sheath of the catheter is flexible and non-expandable in the radial direction along an entire length of the sheath that is at least partially optically transmissible to emit light energy from the light applicator, wherein the catheter is open at a proximal end of the catheter, and wherein the catheter is closed at a distal portion of the catheter.

15. The kit of claim 14, wherein the catheter comprises a single opening only, wherein the opining is at a proximal end of the catheter.

16. A blood vessel treatment device, comprising:

a light applicator; and

a catheter via which the light applicator is inserted into and guided within a blood vessel,

wherein the catheter and light applicator are arranged and adapted such that, at any time during use, the light applicator does not make intraluminal contact with any vessel wall and the light applicator is capable of delivering light energy through a sheath of the catheter so as to emit light energy and cause damage to a vessel wall of the blood vessel, the damage resulting in a subsequent decrease in a diameter of the blood vessel, and

the sheath of the catheter is flexible and non-expandable in the radial direction along an entire length of the sheath that is at least partially optically transmissible to emit light energy from the light applicator, wherein the catheter is open at a proximal end of the catheter, and wherein the catheter is closed at a distal portion of the catheter.