Deployment of polysaccharide markers for treating a site within a patient

• US 9,149,341 B2
• Filed: 11/21/2011
• Issued: 10/06/2015
• Est. Priority Date: 02/02/1999
• Status: Expired due to Fees

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Jones, Michael L., Lubock, Paul
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US13/301,024
• Publication Number:
  US 20120116215A1
• Time in Patent Office: 1,415 Days
• Field of Search: 424465-489, 424/422, 424/426
• US Class Current: 1/1
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00831 Material properties
• CPC Class Codes: A61B 2017/00898 expandable upon contact with fluid
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3962 palpable
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

A method for treating a site within a patient from which tissue has been removed includes providing at least one press-formed marker body formed of polysaccharide and a suitable binder; and placing the at least one of the press-formed marker body within the site where tissue has been removed so as to provide hemostasis therein.

Claims

1. A method for treating a site within a patient from which tissue has been removed, comprising:

providing at least one press-formed marker body formed of polysaccharide and a suitable binder, wherein each of the at least one press-formed marker body is formed of a mixture of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder; and

placing the at least one of the press-formed marker body within the site where tissue has been removed so as to provide hemostasis therein.

2. The method of claim 1, wherein the powder has a particle size less than 0.01 inch.

3. The method of claim 1, wherein the powder has a particle size of about 10 to about 200 micrometers.

4. The method of claim 1, wherein each of the at least one press-formed body has a transverse dimension of about 0.02 to about 0.1 inch.

5. The method of claim 1, wherein each of the at least one press-formed body has a transverse dimension of about 0.035 to about 0.075 inch.

6. The method of claim 1, wherein each of the at least one press-formed body has a length of about 0.1 to about 0.4 inch.

7. The method of claim 1, wherein each of the at least one press-formed body has a length of about 0.15 to about 0.35 inch.

8. The method of claim 1, wherein the at least one press-formed marker body is included in a plurality of marker elements disposed within an inner lumen of a tubular delivery member and the plurality of marker elements are urged out a discharge port in the tubular delivery member.

9. The method of claim 1, comprising a delivery tube with an inner lumen and a discharge port, and a plunger slidably disposed within the inner lumen of the delivery tube, the plunger having a proximal end and a distal end, the proximal end having a head configured to allow an operator to move the plunger within the inner lumen, and having the at least one press-formed marker body disposed in the inner lumen distal to the distal end of the plunger and a releasable plug positioned in the discharge port, further comprising moving the plunger in a distal direction to push all of the at least one press-formed marker body and the releasable plug out of a discharge port and into the site within the patient.

10. A method for use in treating a site within a patient from which tissue has been removed, comprising providing for application at the site at least one unitary marker pellet formed of polysaccharide powder and a suitable binder pressed into a desired shape, wherein each of the at least one press-formed marker body is formed of a mixture of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder, the mixture being placed in a pellet die and subjected to pressure to form a unitary marker pellet.

11. The method of claim 10, comprising placing each individual unitary marker pellet formed of polysaccharide powder within the site where tissue has been removed so as to provide hemostasis therein.

12. A method to facilitate treating a site within a patient from which tissue has been removed, comprising:

providing a plurality of marker members, each marker member of the plurality of marker members comprising a press-formed marker body formed of bioabsorbable polysaccharide and a binder, the bioabsorbable polysaccharide being in sufficient amounts to exhibit hemostatic properties, wherein at least one of the plurality of marker members is formed of a mixture of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder, the plurality of marker members being disposed within an inner lumen of a tubular delivery member; and

placing the plurality of marker members in a lumen of a delivery tube configured to deliver the plurality of marker members into the site within the patient from which the tissue has been removed.